Beneficial effects of microwave-induced argon plasma treatment on cellular behaviors of articular chondrocytes onto nanofibrous Silk fibroin mesh

Soo Chang Jin, Hyun Sook Baek, I Yeonwoo I, Mi Hee Lee, Jung Sung Kim, Jong Chul Park, Young Hwan Park, Dong Kyun Rah, Kie Hyung Chung, Seung Jin Lee, In Ho Han

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

Silk fibroin scaffolds were examined as a biomaterial option for tissue-engineered cartilage-like tissue. In tissue engineering for cartilage repair using a scaffold, initial chondrocyte-material interactions are important for the following cell behaviors. In this study, the surface of nanofibrous silk fibroin (NSF) meshes was modified by a microwave-induced argon plasma treatment in order to improve the cytocompatibility of the meshes used as cartilaginous grafts. In addition, the effects of a plasma treatment on the cellular behavior of chondrocytes on NSF were examined. The plasma treatment resulted in an increase in the hydrophilicity of NSF meshes suggesting that the cytocompatibility of the mesh might be improved. Furthermore, the human articular chondrocytes showed higher viability on the surface-modified NSF meshes. These results suggest that the surface modification of NSF meshes by plasma can enhance the cellular behavior of chondrocytes and may be used in tissue engineering.

Original languageEnglish
Pages (from-to)703-708
Number of pages6
JournalMacromolecular Research
Volume17
Issue number9
DOIs
Publication statusPublished - 2009 Sep

All Science Journal Classification (ASJC) codes

  • Chemical Engineering(all)
  • Organic Chemistry
  • Polymers and Plastics
  • Materials Chemistry

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