Benign lesions after partial nephrectomy for presumed renal cell carcinoma in masses 4 cm or less: Prevalence and predictors in Korean patients

Hwang Gyun Jeon, Seung Ryeol Lee, Kwang Hyun Kim, Young Taik Oh, Namhoon Cho, KoonHo Rha, Seung Choul Yang, WoongKyu Han

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Abstract

Objectives: To investigate the prevalence and predictors associated with benign lesions in Korean patients after partial nephrectomy for presumed renal cell carcinoma (RCC) for lesions measuring ≤ 4 cm. Methods: We retrospectively investigated the medical records of 376 patients who underwent partial nephrectomy for presumed RCC with renal masses of size ≤ 4 cm between June 1997 and December 2008. Demographic and clinicopathologic parameters were compared between benign lesions and RCC. Logistic regression was done to identify parameters associated with benign lesions. Results: In the 376 patients, 81 tumors (21.5%) were benign, including 35 angiomyolipomas (9.3%), 26 complicated cysts (6.9%), 11 oncocytomas (2.9%), and 9 others (2.4%). Univariate analysis showed that time of surgery, female sex, younger age, and normal body mass index (body mass index (BMI) < 23 kg/m2) were associated with benign pathologic findings. On multiple logistic regression analysis, female sex (OR, 4.91; 95% CI, 2.76-08.75; P < .001), age (OR, 0.97; 95% CI, 0.95-0.99; P = .009), and time of surgery (OR, 0.33; 95% CI, 0.11-0.95; P = .040) were independent predictors of benign histologic features. Tumor size, incidental diagnosis, and BMI were not significant predictors (P > .05). Conclusions: Our study with a large cohort of Asian patients showed that the prevalence of benign lesions was similar to previously reported Western studies. However, the most common benign lesion was angiomyolipoma, compared with oncocytoma in Western countries. The results of this study may help clinicians counsel female and younger patients recently diagnosed with small renal masses and decide the most appropriate treatment, including renal biopsies and close observation.

Original languageEnglish
Pages (from-to)574-579
Number of pages6
JournalUrology
Volume76
Issue number3
DOIs
Publication statusPublished - 2010 Jan 1

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Nephrectomy
Renal Cell Carcinoma
Oxyphilic Adenoma
Angiomyolipoma
Kidney
Body Mass Index
Medical Records
Cysts
Logistic Models
Observation
Demography
Biopsy
Neoplasms
Therapeutics

All Science Journal Classification (ASJC) codes

  • Urology

Cite this

Jeon, Hwang Gyun ; Lee, Seung Ryeol ; Kim, Kwang Hyun ; Oh, Young Taik ; Cho, Namhoon ; Rha, KoonHo ; Yang, Seung Choul ; Han, WoongKyu. / Benign lesions after partial nephrectomy for presumed renal cell carcinoma in masses 4 cm or less : Prevalence and predictors in Korean patients. In: Urology. 2010 ; Vol. 76, No. 3. pp. 574-579.
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title = "Benign lesions after partial nephrectomy for presumed renal cell carcinoma in masses 4 cm or less: Prevalence and predictors in Korean patients",
abstract = "Objectives: To investigate the prevalence and predictors associated with benign lesions in Korean patients after partial nephrectomy for presumed renal cell carcinoma (RCC) for lesions measuring ≤ 4 cm. Methods: We retrospectively investigated the medical records of 376 patients who underwent partial nephrectomy for presumed RCC with renal masses of size ≤ 4 cm between June 1997 and December 2008. Demographic and clinicopathologic parameters were compared between benign lesions and RCC. Logistic regression was done to identify parameters associated with benign lesions. Results: In the 376 patients, 81 tumors (21.5{\%}) were benign, including 35 angiomyolipomas (9.3{\%}), 26 complicated cysts (6.9{\%}), 11 oncocytomas (2.9{\%}), and 9 others (2.4{\%}). Univariate analysis showed that time of surgery, female sex, younger age, and normal body mass index (body mass index (BMI) < 23 kg/m2) were associated with benign pathologic findings. On multiple logistic regression analysis, female sex (OR, 4.91; 95{\%} CI, 2.76-08.75; P < .001), age (OR, 0.97; 95{\%} CI, 0.95-0.99; P = .009), and time of surgery (OR, 0.33; 95{\%} CI, 0.11-0.95; P = .040) were independent predictors of benign histologic features. Tumor size, incidental diagnosis, and BMI were not significant predictors (P > .05). Conclusions: Our study with a large cohort of Asian patients showed that the prevalence of benign lesions was similar to previously reported Western studies. However, the most common benign lesion was angiomyolipoma, compared with oncocytoma in Western countries. The results of this study may help clinicians counsel female and younger patients recently diagnosed with small renal masses and decide the most appropriate treatment, including renal biopsies and close observation.",
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Benign lesions after partial nephrectomy for presumed renal cell carcinoma in masses 4 cm or less : Prevalence and predictors in Korean patients. / Jeon, Hwang Gyun; Lee, Seung Ryeol; Kim, Kwang Hyun; Oh, Young Taik; Cho, Namhoon; Rha, KoonHo; Yang, Seung Choul; Han, WoongKyu.

In: Urology, Vol. 76, No. 3, 01.01.2010, p. 574-579.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Benign lesions after partial nephrectomy for presumed renal cell carcinoma in masses 4 cm or less

T2 - Prevalence and predictors in Korean patients

AU - Jeon, Hwang Gyun

AU - Lee, Seung Ryeol

AU - Kim, Kwang Hyun

AU - Oh, Young Taik

AU - Cho, Namhoon

AU - Rha, KoonHo

AU - Yang, Seung Choul

AU - Han, WoongKyu

PY - 2010/1/1

Y1 - 2010/1/1

N2 - Objectives: To investigate the prevalence and predictors associated with benign lesions in Korean patients after partial nephrectomy for presumed renal cell carcinoma (RCC) for lesions measuring ≤ 4 cm. Methods: We retrospectively investigated the medical records of 376 patients who underwent partial nephrectomy for presumed RCC with renal masses of size ≤ 4 cm between June 1997 and December 2008. Demographic and clinicopathologic parameters were compared between benign lesions and RCC. Logistic regression was done to identify parameters associated with benign lesions. Results: In the 376 patients, 81 tumors (21.5%) were benign, including 35 angiomyolipomas (9.3%), 26 complicated cysts (6.9%), 11 oncocytomas (2.9%), and 9 others (2.4%). Univariate analysis showed that time of surgery, female sex, younger age, and normal body mass index (body mass index (BMI) < 23 kg/m2) were associated with benign pathologic findings. On multiple logistic regression analysis, female sex (OR, 4.91; 95% CI, 2.76-08.75; P < .001), age (OR, 0.97; 95% CI, 0.95-0.99; P = .009), and time of surgery (OR, 0.33; 95% CI, 0.11-0.95; P = .040) were independent predictors of benign histologic features. Tumor size, incidental diagnosis, and BMI were not significant predictors (P > .05). Conclusions: Our study with a large cohort of Asian patients showed that the prevalence of benign lesions was similar to previously reported Western studies. However, the most common benign lesion was angiomyolipoma, compared with oncocytoma in Western countries. The results of this study may help clinicians counsel female and younger patients recently diagnosed with small renal masses and decide the most appropriate treatment, including renal biopsies and close observation.

AB - Objectives: To investigate the prevalence and predictors associated with benign lesions in Korean patients after partial nephrectomy for presumed renal cell carcinoma (RCC) for lesions measuring ≤ 4 cm. Methods: We retrospectively investigated the medical records of 376 patients who underwent partial nephrectomy for presumed RCC with renal masses of size ≤ 4 cm between June 1997 and December 2008. Demographic and clinicopathologic parameters were compared between benign lesions and RCC. Logistic regression was done to identify parameters associated with benign lesions. Results: In the 376 patients, 81 tumors (21.5%) were benign, including 35 angiomyolipomas (9.3%), 26 complicated cysts (6.9%), 11 oncocytomas (2.9%), and 9 others (2.4%). Univariate analysis showed that time of surgery, female sex, younger age, and normal body mass index (body mass index (BMI) < 23 kg/m2) were associated with benign pathologic findings. On multiple logistic regression analysis, female sex (OR, 4.91; 95% CI, 2.76-08.75; P < .001), age (OR, 0.97; 95% CI, 0.95-0.99; P = .009), and time of surgery (OR, 0.33; 95% CI, 0.11-0.95; P = .040) were independent predictors of benign histologic features. Tumor size, incidental diagnosis, and BMI were not significant predictors (P > .05). Conclusions: Our study with a large cohort of Asian patients showed that the prevalence of benign lesions was similar to previously reported Western studies. However, the most common benign lesion was angiomyolipoma, compared with oncocytoma in Western countries. The results of this study may help clinicians counsel female and younger patients recently diagnosed with small renal masses and decide the most appropriate treatment, including renal biopsies and close observation.

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