Berberine inhibits the production of lysophosphatidylcholine-induced reactive oxygen species and the ERK1/2 pathway in vascular smooth muscle cells

Bong Jun Cho, Eun Kyoung Im, Jun Hye Kwon, Kyung Hye Lee, Hye Jin Shin, Jaewon Oh, Seok Min Kang, Ji Hyung Chung, Yangsoo Jang

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Lysophosphatidylcholine (lysoPC) induces vascular smooth muscle cell (VSMC) proliferation and migration, which has been proposed to initiate the intimal thickening in coronary atherosclerotic lesions. Berberine is an alkaloid in Berberis aquifolium and many other plants. Recently, it has been shown to have beneficial effects on the cardiovascular system, such as anti-hyperglycemic and cholesterol-lowering activity. In this study, we investigated its effects on lysoPC-induced VSMC proliferation and migration. Berberine inhibited lysoPC-induced DNA synthesis and cell proliferation in VSMCs, as well as migration of the lysoPC-stimulated VSMCs. It also inhibited the activation of extracellular signal-regulated kinases (ERKs) and reduced transcription factor AP-1 activity and the lysoPC-induced increases in intracellular reactive oxygen species (ROS). These results indicate that the inhibitory effects of berberine on lysoPC-stimulated VSMC proliferation and migration are attributable to inhibition of ROS generation and hence of activation of the ERK1/2 pathway. This suggests that berberine has potential in the prevention of atherosclerosis and restenosis.

Original languageEnglish
Pages (from-to)429-434
Number of pages6
JournalMolecules and cells
Volume20
Issue number3
DOIs
Publication statusPublished - 2005 Dec 1

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Berberine
Lysophosphatidylcholines
MAP Kinase Signaling System
Vascular Smooth Muscle
Smooth Muscle Myocytes
Reactive Oxygen Species
Cell Proliferation
Cell Movement
Berberine Alkaloids
Berberis
Tunica Intima
Extracellular Signal-Regulated MAP Kinases
Transcription Factor AP-1
Cardiovascular System
Atherosclerosis
Cholesterol
DNA

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cell Biology

Cite this

Cho, Bong Jun ; Im, Eun Kyoung ; Kwon, Jun Hye ; Lee, Kyung Hye ; Shin, Hye Jin ; Oh, Jaewon ; Kang, Seok Min ; Chung, Ji Hyung ; Jang, Yangsoo. / Berberine inhibits the production of lysophosphatidylcholine-induced reactive oxygen species and the ERK1/2 pathway in vascular smooth muscle cells. In: Molecules and cells. 2005 ; Vol. 20, No. 3. pp. 429-434.
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Berberine inhibits the production of lysophosphatidylcholine-induced reactive oxygen species and the ERK1/2 pathway in vascular smooth muscle cells. / Cho, Bong Jun; Im, Eun Kyoung; Kwon, Jun Hye; Lee, Kyung Hye; Shin, Hye Jin; Oh, Jaewon; Kang, Seok Min; Chung, Ji Hyung; Jang, Yangsoo.

In: Molecules and cells, Vol. 20, No. 3, 01.12.2005, p. 429-434.

Research output: Contribution to journalArticle

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