Beta-blocker therapy at discharge in patients with acute heart failure and atrial fibrillation

Min Soo Ahn, Byung Su Yoo, Jung Woo Son, Min Heui Yu, Dae Ryong Kang, Hae Young Lee, Eun Seok Jeon, Jae Joong Kim, Shung Chull Chae, Sang Hong Baek, Seok Min Kang, Dong Ju Choi, Kye Hun Kim, Myeong Chan Cho, Seong Yoon Kim

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2 Citations (Scopus)


Background: β-blockers (BB) are considered primary therapy in stable heart failure (HF) with reduced ejection fraction (HFrEF) without atrial fibrillation (AF); evidence-based benefits of BB on outcome have been documented. However, BB have not been shown to improve mortality or reduce hospital admissions in HF patients with AF. This study assessed the relationship between BB at discharge and relevant clinical outcomes in acute heart failure (AHF) patients with AF. Methods: From the Korean Acute Heart Failure Registry, 936 HFrEF and 639 HF patients with preserved ejection fraction (HFpEF) and AF were selected. Propensity score (PS) matching accounted for BB selection bias when assessing associations. Results: BB-untreated patients in the overall cohort of HFrEF and HFpEF had greater deteriorated clinical and laboratory characteristics. In the 670 PS-matched cohort of HFrEF patients, incidences of all clinical events at 60 days and 1 year were not different according to use of BB. In the 470 PS-matched cohort of HFpEF, rehospitalization and composite outcome at 6 months and 1 year more frequently occurred in non-users of BB. After adjusting for covariates in the multivariable Cox model of matched cohorts, BB was not associated with clinical outcomes at 60 days and 1 year in HFrEF with AF patients. In HFpEF patients with AF, BB use was associated with reduced 6-month (hazard ratio [HR], 0.38; 95% confidence interval [CI], 0.20-0.74) and 1-year rehospitalization (HR, 0.53; 95% CI, 0.34-0.82). Conclusion: In the HFrEF with AF PS-matched cohort, the use of BB at discharge was not associated with clinical outcome. However, in HFpEF with AF, the use of BB was associated with reduced rehospitalization during the 6-month and 1-year follow up.

Original languageEnglish
Article numbere278
JournalJournal of Korean medical science
Issue number33
Publication statusPublished - 2020 Aug

Bibliographical note

Funding Information:
This work was supported by the Research of Korea Centers for Disease Control and Prevention (grant No. 2010-E63003-00, 2011-E63002-00, 2012-E63005-00, 2013-E63003-00, 2013-E63003-01, 2013-E63003-02, 2016-ER6303-00, and 2019-ER6303-00) and Gangwon branch of the Korean Society of Cardiology.

Publisher Copyright:
© 2020 The Korean Academy of Medical Sciences.

All Science Journal Classification (ASJC) codes

  • Medicine(all)


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