We present a study of a thermal biosensor based on bismuth nanowire that is fabricated for the detection of the human stress hormone cortisol using the Thomson effect. The Bi nanowire was grown using the On-Film Formation of Nanowires (OFF-ON) method. The thermal device was fabricated using photolithography, and the sensing area was modified with immobilized anti-cortisol antibodies conjugated with protein G for the detection of cortisol. The voltages were measured with two probe tips during surface modification to investigate the biochemical reactions in the fabricated thermal biosensor. The Bi nanowire-based thermal biosensor exhibited low detection limit and good selectivity for the detection of cortisol.
Bibliographical noteFunding Information:
The authors S. H. Lee and J. H. Lee contributed equally to this work. This work was supported by the Priority Research Centers Program (2009-0093823), the Converging Research Center Program (2012K001321), and the Pioneer Research Center Program (2013008070) through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology. H.I. Jung acknowledges the project fund (C32730) to J.S. Choi from the Center for Analytical Research of Disaster Science of Korea Basic Science Institute.
All Science Journal Classification (ASJC) codes
- Physics and Astronomy (miscellaneous)