BiFACIAL (Bi omimetic F reestanding A nisotropic C atechol- i nterfaces with A symmetrically L ayered) Films as Versatile Extracellular Matrix Substitutes

Byung Gee Im, Minjae Do, Yoojin Kim, Mira Cho, Jae-Hyung Jang

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Biological naïve extracellular matrices (ECMs) exhibit anisotropic functions in their physical, chemical, and morphological properties. Representative examples include anisotropic skin layers or blood vessels simultaneously facing multiphasic environments. Here, anisotropically multifunctional structures called BiFACIAL (biomimetic freestanding anisotropic catechol-interfaces with asymmetrically layered) films were developed simply by contacting two polysaccharide solutions of heparin-catechol (Hep-C) and chitosan-catechol (Chi-C). Such anisotropic characters were due to controlling catechol cross-linking by alkaline pH, resulting in a trimodular structure: a rigid yet porous Hep-C exterior, nonporous interfacial zone, and soft/highly porous Chi-C interior. The anisotropic features of each layer, including the porosity, rigidity, rheology, composition, and ionic strength, caused the BiFACIAL films to show spontaneously biased stimuli responses and differential behaviors against biological substances (e.g., blood plasma). The films could be created in situ in live animals and imitated the structural/functional aspects of the representative anisotropic tissues (e.g., skin and blood vessels), providing valuable ECM-like platforms for the creation of favorable environments or for tissue regeneration or disease treatment by effectively manipulating cellular behaviors.

Original languageEnglish
Pages (from-to)7602-7613
Number of pages12
JournalACS Applied Materials and Interfaces
Volume10
Issue number9
DOIs
Publication statusPublished - 2018 Mar 7

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Biomimetics
Blood vessels
Chitosan
Skin
Tissue regeneration
Polysaccharides
Ionic strength
Rheology
Rigidity
Animals
Blood
Porosity
Heparin
Tissue
Plasmas
Chemical analysis
catechol

All Science Journal Classification (ASJC) codes

  • Materials Science(all)

Cite this

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title = "BiFACIAL (Bi omimetic F reestanding A nisotropic C atechol- i nterfaces with A symmetrically L ayered) Films as Versatile Extracellular Matrix Substitutes",
abstract = "Biological na{\"i}ve extracellular matrices (ECMs) exhibit anisotropic functions in their physical, chemical, and morphological properties. Representative examples include anisotropic skin layers or blood vessels simultaneously facing multiphasic environments. Here, anisotropically multifunctional structures called BiFACIAL (biomimetic freestanding anisotropic catechol-interfaces with asymmetrically layered) films were developed simply by contacting two polysaccharide solutions of heparin-catechol (Hep-C) and chitosan-catechol (Chi-C). Such anisotropic characters were due to controlling catechol cross-linking by alkaline pH, resulting in a trimodular structure: a rigid yet porous Hep-C exterior, nonporous interfacial zone, and soft/highly porous Chi-C interior. The anisotropic features of each layer, including the porosity, rigidity, rheology, composition, and ionic strength, caused the BiFACIAL films to show spontaneously biased stimuli responses and differential behaviors against biological substances (e.g., blood plasma). The films could be created in situ in live animals and imitated the structural/functional aspects of the representative anisotropic tissues (e.g., skin and blood vessels), providing valuable ECM-like platforms for the creation of favorable environments or for tissue regeneration or disease treatment by effectively manipulating cellular behaviors.",
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BiFACIAL (Bi omimetic F reestanding A nisotropic C atechol- i nterfaces with A symmetrically L ayered) Films as Versatile Extracellular Matrix Substitutes. / Im, Byung Gee; Do, Minjae; Kim, Yoojin; Cho, Mira; Jang, Jae-Hyung.

In: ACS Applied Materials and Interfaces, Vol. 10, No. 9, 07.03.2018, p. 7602-7613.

Research output: Contribution to journalReview article

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AU - Do, Minjae

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AU - Cho, Mira

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N2 - Biological naïve extracellular matrices (ECMs) exhibit anisotropic functions in their physical, chemical, and morphological properties. Representative examples include anisotropic skin layers or blood vessels simultaneously facing multiphasic environments. Here, anisotropically multifunctional structures called BiFACIAL (biomimetic freestanding anisotropic catechol-interfaces with asymmetrically layered) films were developed simply by contacting two polysaccharide solutions of heparin-catechol (Hep-C) and chitosan-catechol (Chi-C). Such anisotropic characters were due to controlling catechol cross-linking by alkaline pH, resulting in a trimodular structure: a rigid yet porous Hep-C exterior, nonporous interfacial zone, and soft/highly porous Chi-C interior. The anisotropic features of each layer, including the porosity, rigidity, rheology, composition, and ionic strength, caused the BiFACIAL films to show spontaneously biased stimuli responses and differential behaviors against biological substances (e.g., blood plasma). The films could be created in situ in live animals and imitated the structural/functional aspects of the representative anisotropic tissues (e.g., skin and blood vessels), providing valuable ECM-like platforms for the creation of favorable environments or for tissue regeneration or disease treatment by effectively manipulating cellular behaviors.

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