Big bottlenecks in cardiovascular tissue engineering

Ngan F. Huang, Vahid Serpooshan, Viola B. Morris, Nazish Sayed, Gaspard Pardon, Oscar J. Abilez, Karina H. Nakayama, Beth L. Pruitt, Sean M. Wu, Young sup Yoon, Jianyi Zhang, Joseph C. Wu

Research output: Contribution to journalComment/debatepeer-review

41 Citations (Scopus)


Although tissue engineering using human-induced pluripotent stem cells is a promising approach for treatment of cardiovascular diseases, some limiting factors include the survival, electrical integration, maturity, scalability, and immune response of three-dimensional (3D) engineered tissues. Here we discuss these important roadblocks facing the tissue engineering field and suggest potential approaches to overcome these challenges.

Original languageEnglish
Article number199
JournalCommunications Biology
Issue number1
Publication statusPublished - 2018 Dec 1

Bibliographical note

Funding Information:
This Comment is a product of discussions of the Progenitor Cell Biology Consortium Workshop, held at Stanford Cardiovascular Institute in April 2017. We acknowledge D. Buxton (National Institutes of Health) and M. Terrin (University of Maryland) for their leadership in organizing the workshop, as well as to other participants of the workshop. We also gratefully acknowledge support of the symposium by the National Institutes of Health Progenitor Cell Biology Consortium (HL099997).

Publisher Copyright:
© 2018, This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply.

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)


Dive into the research topics of 'Big bottlenecks in cardiovascular tissue engineering'. Together they form a unique fingerprint.

Cite this