Big bottlenecks in cardiovascular tissue engineering

Ngan F. Huang; Vahid Serpooshan; Viola B. Morris; Nazish Sayed; Gaspard Pardon; Oscar J. Abilez; Karina H. Nakayama; Beth L. Pruitt; Sean M. Wu; Young sup Yoon; Jianyi Zhang; Joseph C. Wu

doi:10.1038/s42003-018-0202-8

Big bottlenecks in cardiovascular tissue engineering

Ngan F. Huang, Vahid Serpooshan, Viola B. Morris, Nazish Sayed, Gaspard Pardon, Oscar J. Abilez, Karina H. Nakayama, Beth L. Pruitt, Sean M. Wu, Young sup Yoon, Jianyi Zhang, Joseph C. Wu

BioMedical Science Institute

Research output: Contribution to journal › Comment/debate › peer-review

41 Citations (Scopus)

Abstract

Although tissue engineering using human-induced pluripotent stem cells is a promising approach for treatment of cardiovascular diseases, some limiting factors include the survival, electrical integration, maturity, scalability, and immune response of three-dimensional (3D) engineered tissues. Here we discuss these important roadblocks facing the tissue engineering field and suggest potential approaches to overcome these challenges.

Original language	English
Article number	199
Journal	Communications Biology
Volume	1
Issue number	1
DOIs	https://doi.org/10.1038/s42003-018-0202-8
Publication status	Published - 2018 Dec 1

Bibliographical note

Funding Information:
This Comment is a product of discussions of the Progenitor Cell Biology Consortium Workshop, held at Stanford Cardiovascular Institute in April 2017. We acknowledge D. Buxton (National Institutes of Health) and M. Terrin (University of Maryland) for their leadership in organizing the workshop, as well as to other participants of the workshop. We also gratefully acknowledge support of the symposium by the National Institutes of Health Progenitor Cell Biology Consortium (HL099997).

Publisher Copyright:
© 2018, This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply.

All Science Journal Classification (ASJC) codes

Medicine (miscellaneous)
Biochemistry, Genetics and Molecular Biology(all)
Agricultural and Biological Sciences(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/s42003-018-0202-8

Cite this

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abstract = "Although tissue engineering using human-induced pluripotent stem cells is a promising approach for treatment of cardiovascular diseases, some limiting factors include the survival, electrical integration, maturity, scalability, and immune response of three-dimensional (3D) engineered tissues. Here we discuss these important roadblocks facing the tissue engineering field and suggest potential approaches to overcome these challenges.",

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note = "Funding Information: This Comment is a product of discussions of the Progenitor Cell Biology Consortium Workshop, held at Stanford Cardiovascular Institute in April 2017. We acknowledge D. Buxton (National Institutes of Health) and M. Terrin (University of Maryland) for their leadership in organizing the workshop, as well as to other participants of the workshop. We also gratefully acknowledge support of the symposium by the National Institutes of Health Progenitor Cell Biology Consortium (HL099997). Publisher Copyright: {\textcopyright} 2018, This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply.",

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AU - Serpooshan, Vahid

AU - Morris, Viola B.

AU - Sayed, Nazish

AU - Pardon, Gaspard

AU - Abilez, Oscar J.

AU - Nakayama, Karina H.

AU - Pruitt, Beth L.

AU - Wu, Sean M.

AU - Yoon, Young sup

AU - Zhang, Jianyi

AU - Wu, Joseph C.

N1 - Funding Information: This Comment is a product of discussions of the Progenitor Cell Biology Consortium Workshop, held at Stanford Cardiovascular Institute in April 2017. We acknowledge D. Buxton (National Institutes of Health) and M. Terrin (University of Maryland) for their leadership in organizing the workshop, as well as to other participants of the workshop. We also gratefully acknowledge support of the symposium by the National Institutes of Health Progenitor Cell Biology Consortium (HL099997). Publisher Copyright: © 2018, This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply.

PY - 2018/12/1

Y1 - 2018/12/1

N2 - Although tissue engineering using human-induced pluripotent stem cells is a promising approach for treatment of cardiovascular diseases, some limiting factors include the survival, electrical integration, maturity, scalability, and immune response of three-dimensional (3D) engineered tissues. Here we discuss these important roadblocks facing the tissue engineering field and suggest potential approaches to overcome these challenges.

AB - Although tissue engineering using human-induced pluripotent stem cells is a promising approach for treatment of cardiovascular diseases, some limiting factors include the survival, electrical integration, maturity, scalability, and immune response of three-dimensional (3D) engineered tissues. Here we discuss these important roadblocks facing the tissue engineering field and suggest potential approaches to overcome these challenges.

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Big bottlenecks in cardiovascular tissue engineering

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

UN SDGs

Access to Document

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