Bilateral segmental neurofibromatosis with lentiginosis showing a checkerboard pattern

Seh Hyun Park, Si Hyung Lee, Soo Chan Kim

Research output: Contribution to journalArticle

Abstract

Segmental neurofibromatosis, a subtype of neurofibromatosis type 1, is characterized by neurofibromas and/or café-au-lait spots limited to an area or segment of the body. Checkerboard pattern is a rare type of cutaneous mosaic manifestation, characterized by squares or broad ribbons of affected skin with sharp demarcation at the midline. Herein, we report the case of a patient with bilateral segmental neurofibromatosis with lentiginosis showing a checkerboard pattern. Our patient had multiple hyperpigmented macules on her entire body in a checkerboard pattern since birth. Several cafe-au-lait patches were observed on the left buttock and right axilla. A neurofibroma was incidentally found beneath the cafe-au-lait patch by histological examination, which showed ill-defined spindle cells with elongated nuclei at the deep dermis that stained positive for S-100. Based on the clinical presentation and histopathologic results, the patient was diagnosed with bilateral segmental neurofibromatosis with lentiginosis showing a checkerboard pattern. (Korean J Dermatol 2019;57(6):328∼331).

Original languageEnglish
Pages (from-to)328-331
Number of pages4
JournalKorean Journal of Dermatology
Volume57
Issue number6
Publication statusPublished - 2019 Jul

Fingerprint

Lentigo
Neurofibroma
Skin Manifestations
Buttocks
Axilla
Neurofibromatosis 1
Dermis
Parturition
Skin
Neurofibromatosis type 5

All Science Journal Classification (ASJC) codes

  • Dermatology

Cite this

@article{44255f8229d3479ea6ff1d82fcd3330d,
title = "Bilateral segmental neurofibromatosis with lentiginosis showing a checkerboard pattern",
abstract = "Segmental neurofibromatosis, a subtype of neurofibromatosis type 1, is characterized by neurofibromas and/or caf{\'e}-au-lait spots limited to an area or segment of the body. Checkerboard pattern is a rare type of cutaneous mosaic manifestation, characterized by squares or broad ribbons of affected skin with sharp demarcation at the midline. Herein, we report the case of a patient with bilateral segmental neurofibromatosis with lentiginosis showing a checkerboard pattern. Our patient had multiple hyperpigmented macules on her entire body in a checkerboard pattern since birth. Several cafe-au-lait patches were observed on the left buttock and right axilla. A neurofibroma was incidentally found beneath the cafe-au-lait patch by histological examination, which showed ill-defined spindle cells with elongated nuclei at the deep dermis that stained positive for S-100. Based on the clinical presentation and histopathologic results, the patient was diagnosed with bilateral segmental neurofibromatosis with lentiginosis showing a checkerboard pattern. (Korean J Dermatol 2019;57(6):328∼331).",
author = "Park, {Seh Hyun} and Lee, {Si Hyung} and Kim, {Soo Chan}",
year = "2019",
month = "7",
language = "English",
volume = "57",
pages = "328--331",
journal = "Korean Journal of Dermatology",
issn = "0494-4739",
publisher = "Korean Dermatological Association",
number = "6",

}

Bilateral segmental neurofibromatosis with lentiginosis showing a checkerboard pattern. / Park, Seh Hyun; Lee, Si Hyung; Kim, Soo Chan.

In: Korean Journal of Dermatology, Vol. 57, No. 6, 07.2019, p. 328-331.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Bilateral segmental neurofibromatosis with lentiginosis showing a checkerboard pattern

AU - Park, Seh Hyun

AU - Lee, Si Hyung

AU - Kim, Soo Chan

PY - 2019/7

Y1 - 2019/7

N2 - Segmental neurofibromatosis, a subtype of neurofibromatosis type 1, is characterized by neurofibromas and/or café-au-lait spots limited to an area or segment of the body. Checkerboard pattern is a rare type of cutaneous mosaic manifestation, characterized by squares or broad ribbons of affected skin with sharp demarcation at the midline. Herein, we report the case of a patient with bilateral segmental neurofibromatosis with lentiginosis showing a checkerboard pattern. Our patient had multiple hyperpigmented macules on her entire body in a checkerboard pattern since birth. Several cafe-au-lait patches were observed on the left buttock and right axilla. A neurofibroma was incidentally found beneath the cafe-au-lait patch by histological examination, which showed ill-defined spindle cells with elongated nuclei at the deep dermis that stained positive for S-100. Based on the clinical presentation and histopathologic results, the patient was diagnosed with bilateral segmental neurofibromatosis with lentiginosis showing a checkerboard pattern. (Korean J Dermatol 2019;57(6):328∼331).

AB - Segmental neurofibromatosis, a subtype of neurofibromatosis type 1, is characterized by neurofibromas and/or café-au-lait spots limited to an area or segment of the body. Checkerboard pattern is a rare type of cutaneous mosaic manifestation, characterized by squares or broad ribbons of affected skin with sharp demarcation at the midline. Herein, we report the case of a patient with bilateral segmental neurofibromatosis with lentiginosis showing a checkerboard pattern. Our patient had multiple hyperpigmented macules on her entire body in a checkerboard pattern since birth. Several cafe-au-lait patches were observed on the left buttock and right axilla. A neurofibroma was incidentally found beneath the cafe-au-lait patch by histological examination, which showed ill-defined spindle cells with elongated nuclei at the deep dermis that stained positive for S-100. Based on the clinical presentation and histopathologic results, the patient was diagnosed with bilateral segmental neurofibromatosis with lentiginosis showing a checkerboard pattern. (Korean J Dermatol 2019;57(6):328∼331).

UR - http://www.scopus.com/inward/record.url?scp=85071909412&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85071909412&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:85071909412

VL - 57

SP - 328

EP - 331

JO - Korean Journal of Dermatology

JF - Korean Journal of Dermatology

SN - 0494-4739

IS - 6

ER -