Bio-implant as a novel restoration for tooth loss

Dong Joon Lee, Jong Min Lee, Eun Jung Kim, Takashi Takata, Yoshihiro Abiko, Teruo Okano, David W. Green, Masaki Shimono, Han Sung Jung

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

A dental implant is used to replace a missing tooth. Fixing the implant in its natural position requires the engineering of a substantial amount of conformal bone growth inside the implant socket, osseointegration. However, this conventional implant attachment does not include the periodontal ligament (PDL), which has a fundamental role in cushioning high mechanical loads. As a result, tooth implants have a shorter lifetime than the natural tooth and have a high chance of infections. We have engineered a "bio-implant" that provides a living PDL connection for titanium implants. The bio-implant consists of a hydroxyapatite coated titanium screw, ensheathed in cell sheets made from immortalized human periodontal cells. Bio-implants were transplanted into the upper first molar region of a tooth-extraction mouse model. Within 8 weeks the bio-implant generated fibrous connective tissue, a localised blood vessel network and new bone growth fused into the alveolar bone socket. The study presents a bio-implant engineered with human cells, specialised for the root connection, and resulted in the partial reconstruction of a naturalised tooth attachment complex (periodontium), consisting of all the principal tissue types, cementum, PDL and alveolar bone.

Original languageEnglish
Article number7414
JournalScientific reports
Volume7
Issue number1
DOIs
Publication statusPublished - 2017 Dec 1

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Tooth Loss
Periodontal Ligament
Tooth
Bone Development
Titanium
Dental Cementum
Osseointegration
Bone and Bones
Periodontium
Tooth Extraction
Dental Implants
Durapatite
Connective Tissue
Blood Vessels
Infection

All Science Journal Classification (ASJC) codes

  • General

Cite this

Lee, D. J., Lee, J. M., Kim, E. J., Takata, T., Abiko, Y., Okano, T., ... Jung, H. S. (2017). Bio-implant as a novel restoration for tooth loss. Scientific reports, 7(1), [7414]. https://doi.org/10.1038/s41598-017-07819-z
Lee, Dong Joon ; Lee, Jong Min ; Kim, Eun Jung ; Takata, Takashi ; Abiko, Yoshihiro ; Okano, Teruo ; Green, David W. ; Shimono, Masaki ; Jung, Han Sung. / Bio-implant as a novel restoration for tooth loss. In: Scientific reports. 2017 ; Vol. 7, No. 1.
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Lee, DJ, Lee, JM, Kim, EJ, Takata, T, Abiko, Y, Okano, T, Green, DW, Shimono, M & Jung, HS 2017, 'Bio-implant as a novel restoration for tooth loss', Scientific reports, vol. 7, no. 1, 7414. https://doi.org/10.1038/s41598-017-07819-z

Bio-implant as a novel restoration for tooth loss. / Lee, Dong Joon; Lee, Jong Min; Kim, Eun Jung; Takata, Takashi; Abiko, Yoshihiro; Okano, Teruo; Green, David W.; Shimono, Masaki; Jung, Han Sung.

In: Scientific reports, Vol. 7, No. 1, 7414, 01.12.2017.

Research output: Contribution to journalArticle

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AU - Green, David W.

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AU - Jung, Han Sung

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Lee DJ, Lee JM, Kim EJ, Takata T, Abiko Y, Okano T et al. Bio-implant as a novel restoration for tooth loss. Scientific reports. 2017 Dec 1;7(1). 7414. https://doi.org/10.1038/s41598-017-07819-z