Although xanthorrhizol, a sesquiterpenoid oil obtained from the rhizome of Curcuma xanthorrhiza Roxb., known as Java turmeric, has many pharmacological effects, its pharmacokinetics remain unclear. Therefore, we investigated the pharmacokinetics of xanthorrhizol in mice and rats. Xanthorrhizol was administered intravenously and orally to mice, while xanthorrhizol and a Java turmeric supercritical extract were administered orally to rats. The terminal half-life (t1/2), clearance, and absolute bioavailability (BA) of xanthorrhizol in mice were almost 8 h, 6.5 L/h/kg, and 10.2%, respectively. In comparison, the clearance of xanthorrhizol was 3-fold higher in rats than mice. The absolute BAs of xanthorrhizol in rats were 12.9% and 13.4% after oral administration of xanthorrhizol and a supercritical extract, respectively. Our results regarding the pharmacokinetics of xanthorrhizol could guide the conversion of intravenous and oral doses, and help identify the optimal maintenance doses of xanthorrhizol and the extract for desirable pharmacodynamic effects.
|Number of pages||5|
|Journal||Food Science and Biotechnology|
|Publication status||Published - 2022 Sept|
Bibliographical noteFunding Information:
This research was supported by the Chung-Ang University Research Scholarship Grants in 2020 and the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIP) (No. 2022R1A5A6000760).
© 2022, The Korean Society of Food Science and Technology.
All Science Journal Classification (ASJC) codes
- Food Science
- Applied Microbiology and Biotechnology