Biocatalytic asymmetric synthesis of unnatural amino acids through the cascade transfer of amino groups from primary amines onto keto acids

Eul Soo Park, Joo Young Dong, jong shik shin

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Flee to the hills: An unfavorable equilibrium in the amino group transfer between amino acids and keto acids catalyzed by α-transaminases was successfully overcome by coupling with a ω-transaminase reaction as an equilibrium shifter, leading to efficient asymmetric synthesis of diverse unnatural amino acids, including L-tert-leucine and D-phenylglycine.

Original languageEnglish
Pages (from-to)3538-3542
Number of pages5
JournalChemCatChem
Volume5
Issue number12
DOIs
Publication statusPublished - 2013 Dec 1

Fingerprint

Keto Acids
Transaminases
Amines
amino acids
Amino acids
amines
cascades
Amino Acids
leucine
acids
Acids
synthesis
2-phenylglycine

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

Cite this

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Biocatalytic asymmetric synthesis of unnatural amino acids through the cascade transfer of amino groups from primary amines onto keto acids. / Park, Eul Soo; Dong, Joo Young; shin, jong shik.

In: ChemCatChem, Vol. 5, No. 12, 01.12.2013, p. 3538-3542.

Research output: Contribution to journalArticle

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