Biochip technology for monitoring posttraumatic stress disorder (PTSD)

Jung Hyun Lee, Hyo il Jung

Research output: Contribution to journalReview article

7 Citations (Scopus)

Abstract

Posttraumatic stress disorder (PTSD) is an anxiety-related disorder that occurs after an exposure to an emotionally traumatic event, such as a life-threatening experience, and that persists with intrusive and distressing emotion-laden memories. It can trigger further mental health problems, such as depression, bipolar disorder, mania and so on. As a large population suffers from these complex diseases, its treatment results in massive secondary costs to society. Recent diagnosis and treatment of PTSD is based on relatively subjective assessments through diverse symptoms checklists, clinical histories, mental status exams, patient self-reports, and symptom duration. Biological markers have not been identified, and a biochip for PTSD has not yet been developed. In this paper, we briefly review potential biomarkers that could be used to determine the disease stage of PTSD, and we propose new applications of biochip technology with which PTSD could be precisely measured in real time using body fluids, such as blood, saliva, and urine. Microfabrication techniques have made it possible to construct nano/micron-scale sensing parts/chips to accommodate molecular linkers and capture the biomarkers for PTSD. These techniques provide new opportunities to diagnose PTSD in a precise manner.

Original languageEnglish
Pages (from-to)195-200
Number of pages6
JournalBiochip Journal
Volume7
Issue number3
DOIs
Publication statusPublished - 2013 Jan 1

Fingerprint

Biochips
Biomarkers
Post-Traumatic Stress Disorders
Technology
Monitoring
Microfabrication
Body fluids
Medical problems
Blood
Data storage equipment
Bipolar Disorder
Costs
Microtechnology
Life Change Events
Body Fluids
Anxiety Disorders
Checklist
Saliva
Self Report
Mental Health

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering
  • Electrical and Electronic Engineering

Cite this

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Biochip technology for monitoring posttraumatic stress disorder (PTSD). / Lee, Jung Hyun; Jung, Hyo il.

In: Biochip Journal, Vol. 7, No. 3, 01.01.2013, p. 195-200.

Research output: Contribution to journalReview article

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AU - Jung, Hyo il

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AB - Posttraumatic stress disorder (PTSD) is an anxiety-related disorder that occurs after an exposure to an emotionally traumatic event, such as a life-threatening experience, and that persists with intrusive and distressing emotion-laden memories. It can trigger further mental health problems, such as depression, bipolar disorder, mania and so on. As a large population suffers from these complex diseases, its treatment results in massive secondary costs to society. Recent diagnosis and treatment of PTSD is based on relatively subjective assessments through diverse symptoms checklists, clinical histories, mental status exams, patient self-reports, and symptom duration. Biological markers have not been identified, and a biochip for PTSD has not yet been developed. In this paper, we briefly review potential biomarkers that could be used to determine the disease stage of PTSD, and we propose new applications of biochip technology with which PTSD could be precisely measured in real time using body fluids, such as blood, saliva, and urine. Microfabrication techniques have made it possible to construct nano/micron-scale sensing parts/chips to accommodate molecular linkers and capture the biomarkers for PTSD. These techniques provide new opportunities to diagnose PTSD in a precise manner.

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