Biocompatibility and charge injection property of iridium film formed by ion beam assisted deposition

In Seop Lee, Chung Nam Whang, Jong Chul Park, Dong Hee Lee, Won Sun Seo

Research output: Contribution to journalArticlepeer-review

45 Citations (Scopus)


Iridium thin film formed by electron-beam evaporation with simultaneous bombardment of Ar ion beam was evaluated for a stimulating neural electrode. The electrochemical behavior of as-deposited Ir film on Ni-Ti sample was almost identical to bulk Ir by producing much higher open-circuit corrosion potential and much lower anodic current density than the uncoated Ni-Ti in both 1N sulfuric acid and saline solution. The charge injection capability of Ir film was compared with that of Pt electrode currently used mostly as a stimulating neural electrode. The charge density of Pt was small and unchanged with increasing number of activating cycles in 0.1M H2SO4, whilst the Ir film continuously produced increases in charge density. The charge injection density of Ir film in physiological solution was higher for the more activated sample under the identical stimulating condition. Attachment and proliferation with PC12 cells on Ir-coated CP Ti without applying electrical stimulation was similar to the polished CP Ti. A network of neurons and extending axons were formed on Ir film.

Original languageEnglish
Pages (from-to)2225-2231
Number of pages7
Issue number13
Publication statusPublished - 2003 Jun

Bibliographical note

Funding Information:
This work was partially supported by a Grant (No M1-0214-00-0064) of the Ministry of Science and Technology and partially by Korea Research Foundation through the Research Institute for Medical Instruments and Rehabilitation Engineering at Yonsei University, Wonju.

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Bioengineering
  • Ceramics and Composites
  • Biomaterials
  • Mechanics of Materials


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