Biocompatible Carbon Nanotube-Based Hybrid Microfiber for Implantable Electrochemical Actuator and Flexible Electronic Applications

Ting Zheng; Parisa Pour Shahid Saeed Abadi; Jungmok Seo; Byung Hyun Cha; Beatrice Miccoli; Yi Chen Li; Kijun Park; Sunghyun Park; Seon Jin Choi; Rasoul Bayaniahangar; Dongxing Zhang; Soo Hong Lee; Chang Kee Lee; Ali Khademhosseini; Su Ryon Shin

doi:10.1021/acsami.9b02927

Biocompatible Carbon Nanotube-Based Hybrid Microfiber for Implantable Electrochemical Actuator and Flexible Electronic Applications

Ting Zheng, Parisa Pour Shahid Saeed Abadi, Jungmok Seo, Byung Hyun Cha, Beatrice Miccoli, Yi Chen Li, Kijun Park, Sunghyun Park, Seon Jin Choi, Rasoul Bayaniahangar, Dongxing Zhang, Soo Hong Lee, Chang Kee Lee, Ali Khademhosseini, Su Ryon Shin

Department of Electrical and Electronic Engineering

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Abstract

Biocompatible, electrically conductive microfibers with superior mechanical properties have received a great attention due to their potential applications in various biomedical applications such as implantable medical devices, biosensors, artificial muscles, and microactuators. Here, we developed an electrically conductive and mechanically stable carbon nanotube-based microactuator with a low degradability that makes it usable for an implantable device in the body or biological environments. The microfiber was composed of hyaluronic acid (HA) hydrogel and single-wall carbon nanotubes (SWCNTs) (HA/SWCNT). HA hydrogel acts as biosurfactant and ion-conducting binder to improve the dispersion of SWCNTs resulting in enhanced electrical and mechanical properties of the hybrid microfiber. In addition, HA was crosslinked to prevent the leaking of the nanotubes from the composite. Crosslinking of HA hydrogel significantly enhances Young's modulus, the failure strain, the toughness, the stability of the electrical conductivity, and the resistance to biodegradation and creep of hybrid microfibers. The obtained crosslinked HA/SWCNT hybrid microfibers show an excellent capacitance and actuation behavior under mechanical loading with a low potential of ±1 V in a biological environment. Furthermore, the HA/SWCNT microfibers exhibit an excellent in vitro viability. Finally, the biocompatibility is shown through the resolution of an early inflammatory response in less than 3 weeks after the implantation of the microfibers in the subcutaneous tissue of mice.

Original language	English
Pages (from-to)	20615-20627
Number of pages	13
Journal	ACS Applied Materials and Interfaces
Volume	11
Issue number	23
DOIs	https://doi.org/10.1021/acsami.9b02927
Publication status	Published - 2019 Jun 12

Bibliographical note

Funding Information:
The authors gratefully acknowledge funding from the National Institutes of Health (NIH) (EB024403, AR074234, EB026824) and the Department of Defense, ARMI (Biofabusa). The research was partially supported by a micro grant from Brigham Research Institute and Center for Faculty Development and Diversity’sOffice for Research Careers at Brigham and Women’s Hospital. S.R.S. would like to recognize and thank Brigham and Women’s Hospital President Betsy Nabel, MD, and the Reny family, for the Stepping Strong Innovator Award through their generous funding. T.Z. acknowledges the China Scholarship Council (No. 201506120155) and Harbin Institute of Technology for the financial support. P.P.S.S.A. was supported by NIH grant 5T32EB016652-02, American Heart Association grant 17SDG33660925, and an American Fellowship from American Association of University Women. This work was performed in part at the Center for Nanoscale Systems (CNS), a member of the National Nanotechnology Coordinated Infrastructure Network (NNCI), which is supported by the National Science Foundation under NSF award no. 1541959. CNS is part of Harvard University.

Publisher Copyright:
© 2019 American Chemical Society.

All Science Journal Classification (ASJC) codes

Materials Science(all)

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10.1021/acsami.9b02927

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Zheng, T., Pour Shahid Saeed Abadi, P., Seo, J., Cha, B. H., Miccoli, B., Li, Y. C., Park, K., Park, S., Choi, S. J., Bayaniahangar, R., Zhang, D., Lee, S. H., Lee, C. K., Khademhosseini, A., & Shin, S. R. (2019). Biocompatible Carbon Nanotube-Based Hybrid Microfiber for Implantable Electrochemical Actuator and Flexible Electronic Applications. ACS Applied Materials and Interfaces, 11(23), 20615-20627. https://doi.org/10.1021/acsami.9b02927

@article{c214bd7ca2f046bab67ec55f4c61286b,

title = "Biocompatible Carbon Nanotube-Based Hybrid Microfiber for Implantable Electrochemical Actuator and Flexible Electronic Applications",

abstract = "Biocompatible, electrically conductive microfibers with superior mechanical properties have received a great attention due to their potential applications in various biomedical applications such as implantable medical devices, biosensors, artificial muscles, and microactuators. Here, we developed an electrically conductive and mechanically stable carbon nanotube-based microactuator with a low degradability that makes it usable for an implantable device in the body or biological environments. The microfiber was composed of hyaluronic acid (HA) hydrogel and single-wall carbon nanotubes (SWCNTs) (HA/SWCNT). HA hydrogel acts as biosurfactant and ion-conducting binder to improve the dispersion of SWCNTs resulting in enhanced electrical and mechanical properties of the hybrid microfiber. In addition, HA was crosslinked to prevent the leaking of the nanotubes from the composite. Crosslinking of HA hydrogel significantly enhances Young's modulus, the failure strain, the toughness, the stability of the electrical conductivity, and the resistance to biodegradation and creep of hybrid microfibers. The obtained crosslinked HA/SWCNT hybrid microfibers show an excellent capacitance and actuation behavior under mechanical loading with a low potential of ±1 V in a biological environment. Furthermore, the HA/SWCNT microfibers exhibit an excellent in vitro viability. Finally, the biocompatibility is shown through the resolution of an early inflammatory response in less than 3 weeks after the implantation of the microfibers in the subcutaneous tissue of mice.",

author = "Ting Zheng and {Pour Shahid Saeed Abadi}, Parisa and Jungmok Seo and Cha, {Byung Hyun} and Beatrice Miccoli and Li, {Yi Chen} and Kijun Park and Sunghyun Park and Choi, {Seon Jin} and Rasoul Bayaniahangar and Dongxing Zhang and Lee, {Soo Hong} and Lee, {Chang Kee} and Ali Khademhosseini and Shin, {Su Ryon}",

note = "Funding Information: The authors gratefully acknowledge funding from the National Institutes of Health (NIH) (EB024403, AR074234, EB026824) and the Department of Defense, ARMI (Biofabusa). The research was partially supported by a micro grant from Brigham Research Institute and Center for Faculty Development and Diversity{\textquoteright}sOffice for Research Careers at Brigham and Women{\textquoteright}s Hospital. S.R.S. would like to recognize and thank Brigham and Women{\textquoteright}s Hospital President Betsy Nabel, MD, and the Reny family, for the Stepping Strong Innovator Award through their generous funding. T.Z. acknowledges the China Scholarship Council (No. 201506120155) and Harbin Institute of Technology for the financial support. P.P.S.S.A. was supported by NIH grant 5T32EB016652-02, American Heart Association grant 17SDG33660925, and an American Fellowship from American Association of University Women. This work was performed in part at the Center for Nanoscale Systems (CNS), a member of the National Nanotechnology Coordinated Infrastructure Network (NNCI), which is supported by the National Science Foundation under NSF award no. 1541959. CNS is part of Harvard University. Publisher Copyright: {\textcopyright} 2019 American Chemical Society.",

year = "2019",

month = jun,

day = "12",

doi = "10.1021/acsami.9b02927",

language = "English",

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Zheng, T, Pour Shahid Saeed Abadi, P, Seo, J, Cha, BH, Miccoli, B, Li, YC, Park, K, Park, S, Choi, SJ, Bayaniahangar, R, Zhang, D, Lee, SH, Lee, CK, Khademhosseini, A & Shin, SR 2019, 'Biocompatible Carbon Nanotube-Based Hybrid Microfiber for Implantable Electrochemical Actuator and Flexible Electronic Applications', ACS Applied Materials and Interfaces, vol. 11, no. 23, pp. 20615-20627. https://doi.org/10.1021/acsami.9b02927

TY - JOUR

T1 - Biocompatible Carbon Nanotube-Based Hybrid Microfiber for Implantable Electrochemical Actuator and Flexible Electronic Applications

AU - Zheng, Ting

AU - Pour Shahid Saeed Abadi, Parisa

AU - Seo, Jungmok

AU - Cha, Byung Hyun

AU - Miccoli, Beatrice

AU - Li, Yi Chen

AU - Park, Kijun

AU - Park, Sunghyun

AU - Choi, Seon Jin

AU - Bayaniahangar, Rasoul

AU - Zhang, Dongxing

AU - Lee, Soo Hong

AU - Lee, Chang Kee

AU - Khademhosseini, Ali

AU - Shin, Su Ryon

N1 - Funding Information: The authors gratefully acknowledge funding from the National Institutes of Health (NIH) (EB024403, AR074234, EB026824) and the Department of Defense, ARMI (Biofabusa). The research was partially supported by a micro grant from Brigham Research Institute and Center for Faculty Development and Diversity’sOffice for Research Careers at Brigham and Women’s Hospital. S.R.S. would like to recognize and thank Brigham and Women’s Hospital President Betsy Nabel, MD, and the Reny family, for the Stepping Strong Innovator Award through their generous funding. T.Z. acknowledges the China Scholarship Council (No. 201506120155) and Harbin Institute of Technology for the financial support. P.P.S.S.A. was supported by NIH grant 5T32EB016652-02, American Heart Association grant 17SDG33660925, and an American Fellowship from American Association of University Women. This work was performed in part at the Center for Nanoscale Systems (CNS), a member of the National Nanotechnology Coordinated Infrastructure Network (NNCI), which is supported by the National Science Foundation under NSF award no. 1541959. CNS is part of Harvard University. Publisher Copyright: © 2019 American Chemical Society.

PY - 2019/6/12

Y1 - 2019/6/12

N2 - Biocompatible, electrically conductive microfibers with superior mechanical properties have received a great attention due to their potential applications in various biomedical applications such as implantable medical devices, biosensors, artificial muscles, and microactuators. Here, we developed an electrically conductive and mechanically stable carbon nanotube-based microactuator with a low degradability that makes it usable for an implantable device in the body or biological environments. The microfiber was composed of hyaluronic acid (HA) hydrogel and single-wall carbon nanotubes (SWCNTs) (HA/SWCNT). HA hydrogel acts as biosurfactant and ion-conducting binder to improve the dispersion of SWCNTs resulting in enhanced electrical and mechanical properties of the hybrid microfiber. In addition, HA was crosslinked to prevent the leaking of the nanotubes from the composite. Crosslinking of HA hydrogel significantly enhances Young's modulus, the failure strain, the toughness, the stability of the electrical conductivity, and the resistance to biodegradation and creep of hybrid microfibers. The obtained crosslinked HA/SWCNT hybrid microfibers show an excellent capacitance and actuation behavior under mechanical loading with a low potential of ±1 V in a biological environment. Furthermore, the HA/SWCNT microfibers exhibit an excellent in vitro viability. Finally, the biocompatibility is shown through the resolution of an early inflammatory response in less than 3 weeks after the implantation of the microfibers in the subcutaneous tissue of mice.

AB - Biocompatible, electrically conductive microfibers with superior mechanical properties have received a great attention due to their potential applications in various biomedical applications such as implantable medical devices, biosensors, artificial muscles, and microactuators. Here, we developed an electrically conductive and mechanically stable carbon nanotube-based microactuator with a low degradability that makes it usable for an implantable device in the body or biological environments. The microfiber was composed of hyaluronic acid (HA) hydrogel and single-wall carbon nanotubes (SWCNTs) (HA/SWCNT). HA hydrogel acts as biosurfactant and ion-conducting binder to improve the dispersion of SWCNTs resulting in enhanced electrical and mechanical properties of the hybrid microfiber. In addition, HA was crosslinked to prevent the leaking of the nanotubes from the composite. Crosslinking of HA hydrogel significantly enhances Young's modulus, the failure strain, the toughness, the stability of the electrical conductivity, and the resistance to biodegradation and creep of hybrid microfibers. The obtained crosslinked HA/SWCNT hybrid microfibers show an excellent capacitance and actuation behavior under mechanical loading with a low potential of ±1 V in a biological environment. Furthermore, the HA/SWCNT microfibers exhibit an excellent in vitro viability. Finally, the biocompatibility is shown through the resolution of an early inflammatory response in less than 3 weeks after the implantation of the microfibers in the subcutaneous tissue of mice.

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Biocompatible Carbon Nanotube-Based Hybrid Microfiber for Implantable Electrochemical Actuator and Flexible Electronic Applications

Abstract

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