Biocompatible Carbon Nanotube-Based Hybrid Microfiber for Implantable Electrochemical Actuator and Flexible Electronic Applications

Ting Zheng, Parisa Pour Shahid Saeed Abadi, Jungmok Seo, Byung Hyun Cha, Beatrice Miccoli, Yi Chen Li, Kijun Park, Sunghyun Park, Seon Jin Choi, Rasoul Bayaniahangar, Dongxing Zhang, Soo Hong Lee, Chang Kee Lee, Ali Khademhosseini, Su Ryon Shin

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7 Citations (Scopus)

Abstract

Biocompatible, electrically conductive microfibers with superior mechanical properties have received a great attention due to their potential applications in various biomedical applications such as implantable medical devices, biosensors, artificial muscles, and microactuators. Here, we developed an electrically conductive and mechanically stable carbon nanotube-based microactuator with a low degradability that makes it usable for an implantable device in the body or biological environments. The microfiber was composed of hyaluronic acid (HA) hydrogel and single-wall carbon nanotubes (SWCNTs) (HA/SWCNT). HA hydrogel acts as biosurfactant and ion-conducting binder to improve the dispersion of SWCNTs resulting in enhanced electrical and mechanical properties of the hybrid microfiber. In addition, HA was crosslinked to prevent the leaking of the nanotubes from the composite. Crosslinking of HA hydrogel significantly enhances Young's modulus, the failure strain, the toughness, the stability of the electrical conductivity, and the resistance to biodegradation and creep of hybrid microfibers. The obtained crosslinked HA/SWCNT hybrid microfibers show an excellent capacitance and actuation behavior under mechanical loading with a low potential of ±1 V in a biological environment. Furthermore, the HA/SWCNT microfibers exhibit an excellent in vitro viability. Finally, the biocompatibility is shown through the resolution of an early inflammatory response in less than 3 weeks after the implantation of the microfibers in the subcutaneous tissue of mice.

Original languageEnglish
Pages (from-to)20615-20627
Number of pages13
JournalACS Applied Materials and Interfaces
Volume11
Issue number23
DOIs
Publication statusPublished - 2019 Jun 12

All Science Journal Classification (ASJC) codes

  • Materials Science(all)

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  • Cite this

    Zheng, T., Pour Shahid Saeed Abadi, P., Seo, J., Cha, B. H., Miccoli, B., Li, Y. C., Park, K., Park, S., Choi, S. J., Bayaniahangar, R., Zhang, D., Lee, S. H., Lee, C. K., Khademhosseini, A., & Shin, S. R. (2019). Biocompatible Carbon Nanotube-Based Hybrid Microfiber for Implantable Electrochemical Actuator and Flexible Electronic Applications. ACS Applied Materials and Interfaces, 11(23), 20615-20627. https://doi.org/10.1021/acsami.9b02927