Biocompatible Polyhydroxyethylaspartamide-based Micelles with Gadolinium for MRI Contrast Agents

Sang Young Jeong, Hyo Jeong Kim, Byung Kook Kwak, Ha Young Lee, Hasoo Seong, Byung Cheol Shin, Soon Hong Yuk, Sung Joo Hwang, Sun Hang Cho

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10 Citations (Scopus)

Abstract

Biocompatible poly-[N-(2-hydroxyethyl)-d,l-aspartamide]-methoxypoly(ethyleneglycol)-hexadecylamine (PHEA-mPEG-C 16) conjugated with 1,4,7,10-tetraazacyclododecan-1,4,7,10-tetraacetic acid-gadolinium (DOTA-Gd) via ethylenediamine (ED) was synthesized as a magnetic resonance imaging (MRI) contrast agent. Amphiphilic PHEA-mPEG-C 16-ED-DOTA-Gd forms micelle in aqueous solution. All the synthesized materials were characterized by proton nuclear magnetic resonance ( 1H NMR). Micelle size and shape were examined by dynamic light scattering (DLS) and atomic force microscopy (AFM). Micelles with PHEA-mPEG-C 16-ED-DOTA-Gd showed higher relaxivities than the commercially available gadolinium contrast agent. Moreover, the signal intensity of a rabbit liver was effectively increased after intravenous injection of PHEA-mPEG-C 16-ED-DOTA-Gd.

Original languageEnglish
Pages (from-to)1970-1976
Number of pages7
JournalNanoscale Research Letters
Volume5
Issue number12
DOIs
Publication statusPublished - 2010 Dec 1

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Condensed Matter Physics

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    Jeong, S. Y., Kim, H. J., Kwak, B. K., Lee, H. Y., Seong, H., Shin, B. C., Yuk, S. H., Hwang, S. J., & Cho, S. H. (2010). Biocompatible Polyhydroxyethylaspartamide-based Micelles with Gadolinium for MRI Contrast Agents. Nanoscale Research Letters, 5(12), 1970-1976. https://doi.org/10.1007/s11671-010-9734-7