Abstract
Biocompatible poly-[N-(2-hydroxyethyl)-d,l-aspartamide]-methoxypoly(ethyleneglycol)-hexadecylamine (PHEA-mPEG-C 16) conjugated with 1,4,7,10-tetraazacyclododecan-1,4,7,10-tetraacetic acid-gadolinium (DOTA-Gd) via ethylenediamine (ED) was synthesized as a magnetic resonance imaging (MRI) contrast agent. Amphiphilic PHEA-mPEG-C 16-ED-DOTA-Gd forms micelle in aqueous solution. All the synthesized materials were characterized by proton nuclear magnetic resonance ( 1H NMR). Micelle size and shape were examined by dynamic light scattering (DLS) and atomic force microscopy (AFM). Micelles with PHEA-mPEG-C 16-ED-DOTA-Gd showed higher relaxivities than the commercially available gadolinium contrast agent. Moreover, the signal intensity of a rabbit liver was effectively increased after intravenous injection of PHEA-mPEG-C 16-ED-DOTA-Gd.
| Original language | English |
|---|---|
| Pages (from-to) | 1970-1976 |
| Number of pages | 7 |
| Journal | Nanoscale Research Letters |
| Volume | 5 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - 2010 Dec 1 |
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All Science Journal Classification (ASJC) codes
- Materials Science(all)
- Condensed Matter Physics
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Biocompatible Polyhydroxyethylaspartamide-based Micelles with Gadolinium for MRI Contrast Agents. / Jeong, Sang Young; Kim, Hyo Jeong; Kwak, Byung Kook; Lee, Ha Young; Seong, Hasoo; Shin, Byung Cheol; Yuk, Soon Hong; Hwang, Sung Joo; Cho, Sun Hang.
In: Nanoscale Research Letters, Vol. 5, No. 12, 01.12.2010, p. 1970-1976.Research output: Contribution to journal › Article
TY - JOUR
T1 - Biocompatible Polyhydroxyethylaspartamide-based Micelles with Gadolinium for MRI Contrast Agents
AU - Jeong, Sang Young
AU - Kim, Hyo Jeong
AU - Kwak, Byung Kook
AU - Lee, Ha Young
AU - Seong, Hasoo
AU - Shin, Byung Cheol
AU - Yuk, Soon Hong
AU - Hwang, Sung Joo
AU - Cho, Sun Hang
PY - 2010/12/1
Y1 - 2010/12/1
N2 - Biocompatible poly-[N-(2-hydroxyethyl)-d,l-aspartamide]-methoxypoly(ethyleneglycol)-hexadecylamine (PHEA-mPEG-C 16) conjugated with 1,4,7,10-tetraazacyclododecan-1,4,7,10-tetraacetic acid-gadolinium (DOTA-Gd) via ethylenediamine (ED) was synthesized as a magnetic resonance imaging (MRI) contrast agent. Amphiphilic PHEA-mPEG-C 16-ED-DOTA-Gd forms micelle in aqueous solution. All the synthesized materials were characterized by proton nuclear magnetic resonance ( 1H NMR). Micelle size and shape were examined by dynamic light scattering (DLS) and atomic force microscopy (AFM). Micelles with PHEA-mPEG-C 16-ED-DOTA-Gd showed higher relaxivities than the commercially available gadolinium contrast agent. Moreover, the signal intensity of a rabbit liver was effectively increased after intravenous injection of PHEA-mPEG-C 16-ED-DOTA-Gd.
AB - Biocompatible poly-[N-(2-hydroxyethyl)-d,l-aspartamide]-methoxypoly(ethyleneglycol)-hexadecylamine (PHEA-mPEG-C 16) conjugated with 1,4,7,10-tetraazacyclododecan-1,4,7,10-tetraacetic acid-gadolinium (DOTA-Gd) via ethylenediamine (ED) was synthesized as a magnetic resonance imaging (MRI) contrast agent. Amphiphilic PHEA-mPEG-C 16-ED-DOTA-Gd forms micelle in aqueous solution. All the synthesized materials were characterized by proton nuclear magnetic resonance ( 1H NMR). Micelle size and shape were examined by dynamic light scattering (DLS) and atomic force microscopy (AFM). Micelles with PHEA-mPEG-C 16-ED-DOTA-Gd showed higher relaxivities than the commercially available gadolinium contrast agent. Moreover, the signal intensity of a rabbit liver was effectively increased after intravenous injection of PHEA-mPEG-C 16-ED-DOTA-Gd.
UR - http://www.scopus.com/inward/record.url?scp=78649748877&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=78649748877&partnerID=8YFLogxK
U2 - 10.1007/s11671-010-9734-7
DO - 10.1007/s11671-010-9734-7
M3 - Article
AN - SCOPUS:78649748877
VL - 5
SP - 1970
EP - 1976
JO - Nanoscale Research Letters
JF - Nanoscale Research Letters
SN - 1931-7573
IS - 12
ER -