Biodegradable micro-sized discoidal polymeric particles for lung-targeted delivery system

Jun Young Park, Sanghyo Park, Tae Sup Lee, Yong Hwa Hwang, Jung Young Kim, Won Jun Kang, Jaehong Key

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Various types of particle-based drug delivery systems have been explored for the treatment of pulmonary diseases; however, bio-distribution and elimination of the particles should be monitored for better understanding of their therapeutic efficacy and safety. This study aimed to characterize the biological properties of micro-sized discoidal polymeric particles (DPPs) as lung-targeted drug delivery carriers. DPPs were prepared using a top-down fabrication approach and characterized by assessing size and zeta potential. They were labeled with zirconium-89 (89Zr), and bio-distribution studies and PET imaging were performed for 7 days after intravenous administration. Their hydrodynamic size was 2.8 ± 6.1 μm and average zeta potential was −39.9 ± 5.39 mV. At doses of 5, 12.5, and 25 mg/kg, they showed no acute toxicity in nude mice. Desferrioxamine (DFO)-functionalized 89Zr-labeled DPPs gave a decay-corrected radiochemical yield of 82.1 ± 0.2%. Furthermore, 89Zr-DPPs, from chelate-free labeling methods, showed a yield of 48.5 ± 0.9%. Bio-distribution studies and PET imaging showed 89Zr-DFO-DPPs to be mainly accumulated in the lungs and degraded within 3 d of injection. However, 89Zr-DFO-DPPs showed significantly low uptake in the bone. Overall, our results suggested micro-sized DPPs as promising drug delivery carriers for the targeted treatment of various pulmonary diseases.

Original languageEnglish
Article number119331
JournalBiomaterials
Volume218
DOIs
Publication statusPublished - 2019 Oct

Bibliographical note

Funding Information:
This work was supported by the National Research Foundation of Korea ( NRF ) grant funded by the Korea government [MSIP; grant no. 2018R1D1A1B07042339 , 2018R1A2B6004651 , 2017M2A2A6A02019904 , and 2017R1D1A1B03028106 ] and by the Yonsei University Wonju Campus Future-Leading Research Initiative of 2018 [ 2018-62-0054 ]. The authors would like to thank Dong-Su Jang, MFA, (Medical Illustrator, Medical Research Support Section, Yonsei University College of Medicine, Seoul, Korea) for his help with the illustrations.

Funding Information:
This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government [MSIP; grant no. 2018R1D1A1B07042339, 2018R1A2B6004651, 2017M2A2A6A02019904, and 2017R1D1A1B03028106] and by the Yonsei University Wonju Campus Future-Leading Research Initiative of 2018 [2018-62-0054]. The authors would like to thank Dong-Su Jang, MFA, (Medical Illustrator, Medical Research Support Section, Yonsei University College of Medicine, Seoul, Korea) for his help with the illustrations.

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Ceramics and Composites
  • Biophysics
  • Biomaterials
  • Mechanics of Materials

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