Biodegradable microneedle mesh to deliver heterogeneous drugs for vascular diseases

Ji Yong Lee, Kang Ju Lee, WonHyoung Ryu

Research output: Contribution to journalArticle

Abstract

Unlike microneedles for transdermal drug delivery, vascular microneedle devices need to be flexible and deformable to be installed around blood vessels or anastomosis sites that have complex shapes and curvatures. Although previous work has fabricated microneedles on flexible substrates, the flexible substrates are non-biodegradable and have limited bending curvatures. In this work, we developed a microneedle mesh for vascular drug delivery. A biodegradable polymer melt was transferred to individual micro cavities in a mold via a droplet attached at the end of a heated metal pillar. Then, pressure was gently applied to facilitate the filling of the micro cavity with the polymer melt. This was followed by a localized joining of microneedles to a surgical mesh. Vascular tissue insertion characteristics of a microneedle mesh was analyzed with a leporine abdominal aorta. Furthermore, the controlled release of two model drugs at different release rates from a microneedle mesh was demonstrated.

Original languageEnglish
Pages (from-to)145-150
Number of pages6
JournalTransactions of the Korean Society of Mechanical Engineers, B
Volume42
Issue number2
DOIs
Publication statusPublished - 2018 Feb 1

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Polymer melts
Drug delivery
Biodegradable polymers
Blood vessels
Substrates
Joining
Tissue
Metals

All Science Journal Classification (ASJC) codes

  • Mechanical Engineering

Cite this

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Biodegradable microneedle mesh to deliver heterogeneous drugs for vascular diseases. / Lee, Ji Yong; Lee, Kang Ju; Ryu, WonHyoung.

In: Transactions of the Korean Society of Mechanical Engineers, B, Vol. 42, No. 2, 01.02.2018, p. 145-150.

Research output: Contribution to journalArticle

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