Biodegradable Monocrystalline Silicon Photovoltaic Microcells as Power Supplies for Transient Biomedical Implants

Luyao Lu, Zijian Yang, Kathleen Meacham, Caroline Cvetkovic, Elise A. Corbin, Abraham Vázquez-Guardado, Mantian Xue, Lan Yin, Javaneh Boroumand, Grace Pakeltis, Tian Sang, Ki Jun Yu, Debashis Chanda, Rashid Bashir, Robert W. Gereau, Xing Sheng, John A. Rogers

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Bioresorbable electronic materials serve as foundations for implantable devices that provide active diagnostic or therapeutic function over a timeframe matched to a biological process, and then disappear within the body to avoid secondary surgical extraction. Approaches to power supply in these physically transient systems are critically important. This paper describes a fully biodegradable, monocrystalline silicon photovoltaic (PV) platform based on microscale cells (microcells) designed to operate at wavelengths with long penetration depths in biological tissues (red and near infrared wavelengths), such that external illumination can provide realistic levels of power. Systematic characterization and theoretical simulations of operation under porcine skin and fat establish a foundational understanding of these systems and their scalability. In vivo studies of a representative platform capable of generating ≈60 µW of electrical power under 4 mm of porcine skin and fat illustrate an ability to operate blue light-emitting diodes (LEDs) as subdermal implants in rats for 3 d. Here, the PV system fully resorbs after 4 months. Histological analysis reveals that the degradation process introduces no inflammatory responses in the surrounding tissues. The results suggest the potential for using silicon photovoltaic microcells as bioresorbable power supplies for various transient biomedical implants.

Original languageEnglish
Article number1703035
JournalAdvanced Energy Materials
Volume8
Issue number16
DOIs
Publication statusPublished - 2018 Jun 5

Fingerprint

Monocrystalline silicon
Oils and fats
Skin
Fats
Tissue
Wavelength
Photovoltaic cells
Silicon
Light emitting diodes
Scalability
Rats
Lighting
Infrared radiation
Degradation

All Science Journal Classification (ASJC) codes

  • Renewable Energy, Sustainability and the Environment
  • Materials Science(all)

Cite this

Lu, L., Yang, Z., Meacham, K., Cvetkovic, C., Corbin, E. A., Vázquez-Guardado, A., ... Rogers, J. A. (2018). Biodegradable Monocrystalline Silicon Photovoltaic Microcells as Power Supplies for Transient Biomedical Implants. Advanced Energy Materials, 8(16), [1703035]. https://doi.org/10.1002/aenm.201703035
Lu, Luyao ; Yang, Zijian ; Meacham, Kathleen ; Cvetkovic, Caroline ; Corbin, Elise A. ; Vázquez-Guardado, Abraham ; Xue, Mantian ; Yin, Lan ; Boroumand, Javaneh ; Pakeltis, Grace ; Sang, Tian ; Yu, Ki Jun ; Chanda, Debashis ; Bashir, Rashid ; Gereau, Robert W. ; Sheng, Xing ; Rogers, John A. / Biodegradable Monocrystalline Silicon Photovoltaic Microcells as Power Supplies for Transient Biomedical Implants. In: Advanced Energy Materials. 2018 ; Vol. 8, No. 16.
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abstract = "Bioresorbable electronic materials serve as foundations for implantable devices that provide active diagnostic or therapeutic function over a timeframe matched to a biological process, and then disappear within the body to avoid secondary surgical extraction. Approaches to power supply in these physically transient systems are critically important. This paper describes a fully biodegradable, monocrystalline silicon photovoltaic (PV) platform based on microscale cells (microcells) designed to operate at wavelengths with long penetration depths in biological tissues (red and near infrared wavelengths), such that external illumination can provide realistic levels of power. Systematic characterization and theoretical simulations of operation under porcine skin and fat establish a foundational understanding of these systems and their scalability. In vivo studies of a representative platform capable of generating ≈60 µW of electrical power under 4 mm of porcine skin and fat illustrate an ability to operate blue light-emitting diodes (LEDs) as subdermal implants in rats for 3 d. Here, the PV system fully resorbs after 4 months. Histological analysis reveals that the degradation process introduces no inflammatory responses in the surrounding tissues. The results suggest the potential for using silicon photovoltaic microcells as bioresorbable power supplies for various transient biomedical implants.",
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Lu, L, Yang, Z, Meacham, K, Cvetkovic, C, Corbin, EA, Vázquez-Guardado, A, Xue, M, Yin, L, Boroumand, J, Pakeltis, G, Sang, T, Yu, KJ, Chanda, D, Bashir, R, Gereau, RW, Sheng, X & Rogers, JA 2018, 'Biodegradable Monocrystalline Silicon Photovoltaic Microcells as Power Supplies for Transient Biomedical Implants', Advanced Energy Materials, vol. 8, no. 16, 1703035. https://doi.org/10.1002/aenm.201703035

Biodegradable Monocrystalline Silicon Photovoltaic Microcells as Power Supplies for Transient Biomedical Implants. / Lu, Luyao; Yang, Zijian; Meacham, Kathleen; Cvetkovic, Caroline; Corbin, Elise A.; Vázquez-Guardado, Abraham; Xue, Mantian; Yin, Lan; Boroumand, Javaneh; Pakeltis, Grace; Sang, Tian; Yu, Ki Jun; Chanda, Debashis; Bashir, Rashid; Gereau, Robert W.; Sheng, Xing; Rogers, John A.

In: Advanced Energy Materials, Vol. 8, No. 16, 1703035, 05.06.2018.

Research output: Contribution to journalArticle

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T1 - Biodegradable Monocrystalline Silicon Photovoltaic Microcells as Power Supplies for Transient Biomedical Implants

AU - Lu, Luyao

AU - Yang, Zijian

AU - Meacham, Kathleen

AU - Cvetkovic, Caroline

AU - Corbin, Elise A.

AU - Vázquez-Guardado, Abraham

AU - Xue, Mantian

AU - Yin, Lan

AU - Boroumand, Javaneh

AU - Pakeltis, Grace

AU - Sang, Tian

AU - Yu, Ki Jun

AU - Chanda, Debashis

AU - Bashir, Rashid

AU - Gereau, Robert W.

AU - Sheng, Xing

AU - Rogers, John A.

PY - 2018/6/5

Y1 - 2018/6/5

N2 - Bioresorbable electronic materials serve as foundations for implantable devices that provide active diagnostic or therapeutic function over a timeframe matched to a biological process, and then disappear within the body to avoid secondary surgical extraction. Approaches to power supply in these physically transient systems are critically important. This paper describes a fully biodegradable, monocrystalline silicon photovoltaic (PV) platform based on microscale cells (microcells) designed to operate at wavelengths with long penetration depths in biological tissues (red and near infrared wavelengths), such that external illumination can provide realistic levels of power. Systematic characterization and theoretical simulations of operation under porcine skin and fat establish a foundational understanding of these systems and their scalability. In vivo studies of a representative platform capable of generating ≈60 µW of electrical power under 4 mm of porcine skin and fat illustrate an ability to operate blue light-emitting diodes (LEDs) as subdermal implants in rats for 3 d. Here, the PV system fully resorbs after 4 months. Histological analysis reveals that the degradation process introduces no inflammatory responses in the surrounding tissues. The results suggest the potential for using silicon photovoltaic microcells as bioresorbable power supplies for various transient biomedical implants.

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