Biodegradation-tunable mesoporous silica nanorods for controlled drug delivery

Sung Bum Park, Young Ho Joo, Hyunryung Kim, WonHyoung Ryu, Yong Il Park

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Mesoporous silica in the forms of micro- or nanoparticles showed great potentials in the field of controlled drug delivery. However, for precision control of drug release from mesoporous silica-based delivery systems, it is critical to control the rate of biodegradation. Thus, in this study, we demonstrate a simple and robust method to fabricate "biodegradation-tunable" mesoporous silica nanorods based on capillary wetting of anodic aluminum oxide (AAO) template with an aqueous alkoxide precursor solution. The porosity and nanostructure of silica nanorods were conveniently controlled by adjusting the water/alkoxide molar ratio of precursor solutions, heat-treatment temperature, and Na addition. The porosity and biodegradation kinetics of the fabricated mesoporous nanorods were analyzed using N2 adsorption/desorption isotherm, TGA, DTA, and XRD. Finally, the performance of the mesoporous silica nanorods as drug delivery carrier was demonstrated with initial burst and subsequent "zero-order" release of anti-cancer drug, doxorubicin.

Original languageEnglish
Pages (from-to)64-73
Number of pages10
JournalMaterials Science and Engineering C
Volume50
DOIs
Publication statusPublished - 2015 May 1

Fingerprint

Controlled drug delivery
biodegradation
Biodegradation
Nanorods
Silicon Dioxide
nanorods
delivery
drugs
Silica
silicon dioxide
alkoxides
Porosity
porosity
Aluminum Oxide
microparticles
Drug delivery
Pharmaceutical Preparations
Doxorubicin
Differential thermal analysis
wetting

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

Cite this

Park, Sung Bum ; Joo, Young Ho ; Kim, Hyunryung ; Ryu, WonHyoung ; Park, Yong Il. / Biodegradation-tunable mesoporous silica nanorods for controlled drug delivery. In: Materials Science and Engineering C. 2015 ; Vol. 50. pp. 64-73.
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abstract = "Mesoporous silica in the forms of micro- or nanoparticles showed great potentials in the field of controlled drug delivery. However, for precision control of drug release from mesoporous silica-based delivery systems, it is critical to control the rate of biodegradation. Thus, in this study, we demonstrate a simple and robust method to fabricate {"}biodegradation-tunable{"} mesoporous silica nanorods based on capillary wetting of anodic aluminum oxide (AAO) template with an aqueous alkoxide precursor solution. The porosity and nanostructure of silica nanorods were conveniently controlled by adjusting the water/alkoxide molar ratio of precursor solutions, heat-treatment temperature, and Na addition. The porosity and biodegradation kinetics of the fabricated mesoporous nanorods were analyzed using N2 adsorption/desorption isotherm, TGA, DTA, and XRD. Finally, the performance of the mesoporous silica nanorods as drug delivery carrier was demonstrated with initial burst and subsequent {"}zero-order{"} release of anti-cancer drug, doxorubicin.",
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Biodegradation-tunable mesoporous silica nanorods for controlled drug delivery. / Park, Sung Bum; Joo, Young Ho; Kim, Hyunryung; Ryu, WonHyoung; Park, Yong Il.

In: Materials Science and Engineering C, Vol. 50, 01.05.2015, p. 64-73.

Research output: Contribution to journalArticle

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