Abstract
Purpose: [18F]Mefway is a positron emission tomography (PET) radioligand for quantification of the brain serotonin 1A (5-HT1A) receptor density. The purpose of this study was to evaluate the radiation safety of [18F]Mefway in humans. Procedures: Six healthy volunteers (three males and three females) were whole-body PET scanned for 114 min after injection of [18F]Mefway (226 ± 35 MBq). Estimated radiation doses were determined by the OLINDA/EXM software. Results: [18F]Mefway was safe and well tolerated by all subjects. Residence time ranges from 0 (gallbladder) to 0.822 h (urinary bladder wall). While the estimated radiation doses in the reproductive and blood-forming organs were below 13.35–22.87 μSv/MBq, radiation dose in the urinary bladder wall was 471 μSv/MBq. The mean effective dose was 40.23 ± 6.63 μSv/MBq. Conclusion: For a typical single injection of 185 MBq (5 mCi), the dose will result in 87.1 mSv for the urinary bladder wall. To reduce radiation burden, the bladder voiding can be used before [18F]Mefway PET scan.
| Original language | English |
|---|---|
| Pages (from-to) | 803-806 |
| Number of pages | 4 |
| Journal | Molecular Imaging and Biology |
| Volume | 18 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 2016 Dec 1 |
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All Science Journal Classification (ASJC) codes
- Oncology
- Radiology Nuclear Medicine and imaging
- Cancer Research
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Biodistribution and Radiation Dosimetry of [18F]Mefway in Humans. / Choi, Jae Yong; Lyoo, Chulhyoung; Kim, Jin Su; Kim, Kyeong Min; Lee, Minkyung; Ryu, Young Hoon.
In: Molecular Imaging and Biology, Vol. 18, No. 6, 01.12.2016, p. 803-806.Research output: Contribution to journal › Article
TY - JOUR
T1 - Biodistribution and Radiation Dosimetry of [18F]Mefway in Humans
AU - Choi, Jae Yong
AU - Lyoo, Chulhyoung
AU - Kim, Jin Su
AU - Kim, Kyeong Min
AU - Lee, Minkyung
AU - Ryu, Young Hoon
PY - 2016/12/1
Y1 - 2016/12/1
N2 - Purpose: [18F]Mefway is a positron emission tomography (PET) radioligand for quantification of the brain serotonin 1A (5-HT1A) receptor density. The purpose of this study was to evaluate the radiation safety of [18F]Mefway in humans. Procedures: Six healthy volunteers (three males and three females) were whole-body PET scanned for 114 min after injection of [18F]Mefway (226 ± 35 MBq). Estimated radiation doses were determined by the OLINDA/EXM software. Results: [18F]Mefway was safe and well tolerated by all subjects. Residence time ranges from 0 (gallbladder) to 0.822 h (urinary bladder wall). While the estimated radiation doses in the reproductive and blood-forming organs were below 13.35–22.87 μSv/MBq, radiation dose in the urinary bladder wall was 471 μSv/MBq. The mean effective dose was 40.23 ± 6.63 μSv/MBq. Conclusion: For a typical single injection of 185 MBq (5 mCi), the dose will result in 87.1 mSv for the urinary bladder wall. To reduce radiation burden, the bladder voiding can be used before [18F]Mefway PET scan.
AB - Purpose: [18F]Mefway is a positron emission tomography (PET) radioligand for quantification of the brain serotonin 1A (5-HT1A) receptor density. The purpose of this study was to evaluate the radiation safety of [18F]Mefway in humans. Procedures: Six healthy volunteers (three males and three females) were whole-body PET scanned for 114 min after injection of [18F]Mefway (226 ± 35 MBq). Estimated radiation doses were determined by the OLINDA/EXM software. Results: [18F]Mefway was safe and well tolerated by all subjects. Residence time ranges from 0 (gallbladder) to 0.822 h (urinary bladder wall). While the estimated radiation doses in the reproductive and blood-forming organs were below 13.35–22.87 μSv/MBq, radiation dose in the urinary bladder wall was 471 μSv/MBq. The mean effective dose was 40.23 ± 6.63 μSv/MBq. Conclusion: For a typical single injection of 185 MBq (5 mCi), the dose will result in 87.1 mSv for the urinary bladder wall. To reduce radiation burden, the bladder voiding can be used before [18F]Mefway PET scan.
UR - http://www.scopus.com/inward/record.url?scp=84964466834&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84964466834&partnerID=8YFLogxK
U2 - 10.1007/s11307-016-0955-8
DO - 10.1007/s11307-016-0955-8
M3 - Article
C2 - 27126460
AN - SCOPUS:84964466834
VL - 18
SP - 803
EP - 806
JO - Molecular Imaging and Biology
JF - Molecular Imaging and Biology
SN - 1536-1632
IS - 6
ER -