Biodistribution and Radiation Dosimetry of [18F]Mefway in Humans

Jae Yong Choi, Chulhyoung Lyoo, Jin Su Kim, Kyeong Min Kim, Minkyung Lee, Young Hoon Ryu

Research output: Contribution to journalArticle

Abstract

Purpose: [18F]Mefway is a positron emission tomography (PET) radioligand for quantification of the brain serotonin 1A (5-HT1A) receptor density. The purpose of this study was to evaluate the radiation safety of [18F]Mefway in humans. Procedures: Six healthy volunteers (three males and three females) were whole-body PET scanned for 114 min after injection of [18F]Mefway (226 ± 35 MBq). Estimated radiation doses were determined by the OLINDA/EXM software. Results: [18F]Mefway was safe and well tolerated by all subjects. Residence time ranges from 0 (gallbladder) to 0.822 h (urinary bladder wall). While the estimated radiation doses in the reproductive and blood-forming organs were below 13.35–22.87 μSv/MBq, radiation dose in the urinary bladder wall was 471 μSv/MBq. The mean effective dose was 40.23 ± 6.63 μSv/MBq. Conclusion: For a typical single injection of 185 MBq (5 mCi), the dose will result in 87.1 mSv for the urinary bladder wall. To reduce radiation burden, the bladder voiding can be used before [18F]Mefway PET scan.

Original languageEnglish
Pages (from-to)803-806
Number of pages4
JournalMolecular Imaging and Biology
Volume18
Issue number6
DOIs
Publication statusPublished - 2016 Dec 1

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Radiometry
Radiation
Urinary Bladder
Positron-Emission Tomography
Injections
Receptor, Serotonin, 5-HT1A
Gallbladder
Healthy Volunteers
Software
mefway
Safety
Brain

All Science Journal Classification (ASJC) codes

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

Cite this

Choi, Jae Yong ; Lyoo, Chulhyoung ; Kim, Jin Su ; Kim, Kyeong Min ; Lee, Minkyung ; Ryu, Young Hoon. / Biodistribution and Radiation Dosimetry of [18F]Mefway in Humans. In: Molecular Imaging and Biology. 2016 ; Vol. 18, No. 6. pp. 803-806.
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abstract = "Purpose: [18F]Mefway is a positron emission tomography (PET) radioligand for quantification of the brain serotonin 1A (5-HT1A) receptor density. The purpose of this study was to evaluate the radiation safety of [18F]Mefway in humans. Procedures: Six healthy volunteers (three males and three females) were whole-body PET scanned for 114 min after injection of [18F]Mefway (226 ± 35 MBq). Estimated radiation doses were determined by the OLINDA/EXM software. Results: [18F]Mefway was safe and well tolerated by all subjects. Residence time ranges from 0 (gallbladder) to 0.822 h (urinary bladder wall). While the estimated radiation doses in the reproductive and blood-forming organs were below 13.35–22.87 μSv/MBq, radiation dose in the urinary bladder wall was 471 μSv/MBq. The mean effective dose was 40.23 ± 6.63 μSv/MBq. Conclusion: For a typical single injection of 185 MBq (5 mCi), the dose will result in 87.1 mSv for the urinary bladder wall. To reduce radiation burden, the bladder voiding can be used before [18F]Mefway PET scan.",
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Biodistribution and Radiation Dosimetry of [18F]Mefway in Humans. / Choi, Jae Yong; Lyoo, Chulhyoung; Kim, Jin Su; Kim, Kyeong Min; Lee, Minkyung; Ryu, Young Hoon.

In: Molecular Imaging and Biology, Vol. 18, No. 6, 01.12.2016, p. 803-806.

Research output: Contribution to journalArticle

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