Biodistribution and Radiation Dosimetry of [18F]Mefway in Humans

Jae Yong Choi; Chul Hyoung Lyoo; Jin Su Kim; Kyeong Min Kim; Minkyung Lee; Young Hoon Ryu

doi:10.1007/s11307-016-0955-8

Biodistribution and Radiation Dosimetry of [¹⁸F]Mefway in Humans

Jae Yong Choi, Chul Hyoung Lyoo, Jin Su Kim, Kyeong Min Kim, Minkyung Lee, Young Hoon Ryu

Department of Neurology

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Purpose: [¹⁸F]Mefway is a positron emission tomography (PET) radioligand for quantification of the brain serotonin 1A (5-HT_1A) receptor density. The purpose of this study was to evaluate the radiation safety of [¹⁸F]Mefway in humans. Procedures: Six healthy volunteers (three males and three females) were whole-body PET scanned for 114 min after injection of [¹⁸F]Mefway (226 ± 35 MBq). Estimated radiation doses were determined by the OLINDA/EXM software. Results: [¹⁸F]Mefway was safe and well tolerated by all subjects. Residence time ranges from 0 (gallbladder) to 0.822 h (urinary bladder wall). While the estimated radiation doses in the reproductive and blood-forming organs were below 13.35–22.87 μSv/MBq, radiation dose in the urinary bladder wall was 471 μSv/MBq. The mean effective dose was 40.23 ± 6.63 μSv/MBq. Conclusion: For a typical single injection of 185 MBq (5 mCi), the dose will result in 87.1 mSv for the urinary bladder wall. To reduce radiation burden, the bladder voiding can be used before [¹⁸F]Mefway PET scan.

Original language	English
Pages (from-to)	803-806
Number of pages	4
Journal	Molecular Imaging and Biology
Volume	18
Issue number	6
DOIs	https://doi.org/10.1007/s11307-016-0955-8
Publication status	Published - 2016 Dec 1

Bibliographical note

Funding Information:
This research was supported by the Nuclear R&D Program of the National Research Foundation of Korea (Grant No. NRF-2015M2A2A7027110) and INHA UNIVERSITY Research Grant (INHA-52574). The authors would like to express their sincere gratitude to Tae Ho Song and Won Taek Lee (PET technologists) who managed all PET experiments.

Publisher Copyright:
© 2016, World Molecular Imaging Society.

All Science Journal Classification (ASJC) codes

Oncology
Radiology Nuclear Medicine and imaging
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/s11307-016-0955-8

Cite this

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title = "Biodistribution and Radiation Dosimetry of [18F]Mefway in Humans",

abstract = "Purpose: [18F]Mefway is a positron emission tomography (PET) radioligand for quantification of the brain serotonin 1A (5-HT1A) receptor density. The purpose of this study was to evaluate the radiation safety of [18F]Mefway in humans. Procedures: Six healthy volunteers (three males and three females) were whole-body PET scanned for 114 min after injection of [18F]Mefway (226 ± 35 MBq). Estimated radiation doses were determined by the OLINDA/EXM software. Results: [18F]Mefway was safe and well tolerated by all subjects. Residence time ranges from 0 (gallbladder) to 0.822 h (urinary bladder wall). While the estimated radiation doses in the reproductive and blood-forming organs were below 13.35–22.87 μSv/MBq, radiation dose in the urinary bladder wall was 471 μSv/MBq. The mean effective dose was 40.23 ± 6.63 μSv/MBq. Conclusion: For a typical single injection of 185 MBq (5 mCi), the dose will result in 87.1 mSv for the urinary bladder wall. To reduce radiation burden, the bladder voiding can be used before [18F]Mefway PET scan.",

author = "Choi, {Jae Yong} and Lyoo, {Chul Hyoung} and Kim, {Jin Su} and Kim, {Kyeong Min} and Minkyung Lee and Ryu, {Young Hoon}",

note = "Funding Information: This research was supported by the Nuclear R&D Program of the National Research Foundation of Korea (Grant No. NRF-2015M2A2A7027110) and INHA UNIVERSITY Research Grant (INHA-52574). The authors would like to express their sincere gratitude to Tae Ho Song and Won Taek Lee (PET technologists) who managed all PET experiments. Publisher Copyright: {\textcopyright} 2016, World Molecular Imaging Society.",

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AU - Choi, Jae Yong

AU - Lyoo, Chul Hyoung

AU - Kim, Jin Su

AU - Kim, Kyeong Min

AU - Lee, Minkyung

AU - Ryu, Young Hoon

N1 - Funding Information: This research was supported by the Nuclear R&D Program of the National Research Foundation of Korea (Grant No. NRF-2015M2A2A7027110) and INHA UNIVERSITY Research Grant (INHA-52574). The authors would like to express their sincere gratitude to Tae Ho Song and Won Taek Lee (PET technologists) who managed all PET experiments. Publisher Copyright: © 2016, World Molecular Imaging Society.

PY - 2016/12/1

Y1 - 2016/12/1

N2 - Purpose: [18F]Mefway is a positron emission tomography (PET) radioligand for quantification of the brain serotonin 1A (5-HT1A) receptor density. The purpose of this study was to evaluate the radiation safety of [18F]Mefway in humans. Procedures: Six healthy volunteers (three males and three females) were whole-body PET scanned for 114 min after injection of [18F]Mefway (226 ± 35 MBq). Estimated radiation doses were determined by the OLINDA/EXM software. Results: [18F]Mefway was safe and well tolerated by all subjects. Residence time ranges from 0 (gallbladder) to 0.822 h (urinary bladder wall). While the estimated radiation doses in the reproductive and blood-forming organs were below 13.35–22.87 μSv/MBq, radiation dose in the urinary bladder wall was 471 μSv/MBq. The mean effective dose was 40.23 ± 6.63 μSv/MBq. Conclusion: For a typical single injection of 185 MBq (5 mCi), the dose will result in 87.1 mSv for the urinary bladder wall. To reduce radiation burden, the bladder voiding can be used before [18F]Mefway PET scan.

AB - Purpose: [18F]Mefway is a positron emission tomography (PET) radioligand for quantification of the brain serotonin 1A (5-HT1A) receptor density. The purpose of this study was to evaluate the radiation safety of [18F]Mefway in humans. Procedures: Six healthy volunteers (three males and three females) were whole-body PET scanned for 114 min after injection of [18F]Mefway (226 ± 35 MBq). Estimated radiation doses were determined by the OLINDA/EXM software. Results: [18F]Mefway was safe and well tolerated by all subjects. Residence time ranges from 0 (gallbladder) to 0.822 h (urinary bladder wall). While the estimated radiation doses in the reproductive and blood-forming organs were below 13.35–22.87 μSv/MBq, radiation dose in the urinary bladder wall was 471 μSv/MBq. The mean effective dose was 40.23 ± 6.63 μSv/MBq. Conclusion: For a typical single injection of 185 MBq (5 mCi), the dose will result in 87.1 mSv for the urinary bladder wall. To reduce radiation burden, the bladder voiding can be used before [18F]Mefway PET scan.

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