Bioequivalence data analysis for the case of separate hospitalization

Kyun Seop Bae, Seung Ho Kang

Research output: Contribution to journalArticle

Abstract

A bioequivalence study is usually conducted with the same-day drug administration. However, hospitalization is occasionally separated for logistical, operational, or other reasons. Recently, there was a case of separate hospitalization because of difficulties in subject recruitment. This article suggests a better way of bioequivalence data analysis for the case of separate hospitalization. The key features are (1) considering the hospitalization date as a random effect than a fixed effect and 2) using “PROC MIXED” instead of “PROC GLM” to include incomplete subject data.

Original languageEnglish
Pages (from-to)93-100
Number of pages8
JournalTranslational and Clinical Pharmacology
Volume25
Issue number2
DOIs
Publication statusPublished - 2017 Jan 1

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All Science Journal Classification (ASJC) codes

  • Pharmacology (medical)

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