Bioinspired application of dendrimers: From bio-mimicry to biomedical applications

Woo Dong Jang, K. M. Kamruzzaman Selim, Chi Hwa Lee, Inn Kyu Kang

Research output: Contribution to journalReview articlepeer-review

161 Citations (Scopus)

Abstract

Over the past few years, utilization of dendrimers in nano-biotechnology applications such as bio-mimicry, diagnostics, and therapeutics has attracted a great deal of attention, far beyond that of other classical polymers and oligomers. The intensified interest in dendrimers is due to their unique characteristics, which include excellent structural uniformity, multivalency, high degree of branching, well-defined molecular architecture, and highly variable chemical composition. Indeed, dendrimers can possess many terminal functional groups that can be chemically linked to other moieties in order to adjust their surface properties for applications such as biomimetic nano-devices. Furthermore, by utilizing the homogeneity of their three-dimensional architecture, a variety of biologically active agents can be incorporated into dendrimers to form biologically active conjugates, including novel drug carriers. Here, we review several aspects of bio-inspired dendrimer applications, giving special focus to their use as protein mimics, drug and gene delivery agents, anticancer and antiviral therapeutics, and in biomedical diagnostic applications. We also provide a brief introduction to the preparation of dendrimers and review their physicochemical and biological properties.

Original languageEnglish
Pages (from-to)1-23
Number of pages23
JournalProgress in Polymer Science (Oxford)
Volume34
Issue number1
DOIs
Publication statusPublished - 2009 Jan

Bibliographical note

Funding Information:
This work was supported by the Korea Science and Engineering Foundation through the Center for Bioactive Molecular Hybrids (CBMH).

All Science Journal Classification (ASJC) codes

  • Ceramics and Composites
  • Surfaces and Interfaces
  • Polymers and Plastics
  • Organic Chemistry
  • Materials Chemistry

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