Biological advantages of porous hydroxyapatite scaffold made by solid freeform fabrication for bone tissue regeneration

Byeong Ju Kwon, Jungsung Kim, Yong Hwa Kim, Mi Hee Lee, Hyun Sook Baek, Dae Hyung Lee, Hye Lee Kim, Hyok Jin Seo, Min Hyeon Lee, Soon Young Kwon, Min Ah Koo, Jongchul Park

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Presently, commercially available porous bone substitutes are manufactured by the sacrificial template method, direct foaming method, and polymer replication method (PRM). However, current manufacturing methods provide only the simplest form of the bone scaffold and cannot easily control pore size. Recent developments in medical imaging technology, computer-aided design, and solid freeform fabrication (SFF), have made it possible to accurately produce porous synthetic bone scaffolds to fit the defected bone shape. Porous scaffolds were fabricated by SFF and PRM for a comparison of physical and mechanical properties of scaffold. The suggested three-dimensional model has interconnected cubic pores of 500μm and its calculated porosity is 25%. Whereas hydroxyapatite scaffolds fabricated by SFF had connective macropores, those by PRM formed a closed pore external surface with internally interconnected pores. SFF was supposed to be a proper method for fabricating an interconnected macroporous network. Biocompatibility was confirmed by testing the cytotoxicity, hemolysis, irritation, sensitization, and implantation. In summary, the aim was to verify the safety and efficacy of the scaffolds by biomechanical and biological tests with the hope that this research could promote the feasibility of using the scaffolds as a bone substitute.

Original languageEnglish
Pages (from-to)663-670
Number of pages8
JournalArtificial Organs
Volume37
Issue number7
DOIs
Publication statusPublished - 2013 Jul 1

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Layered manufacturing
Tissue regeneration
Bone Regeneration
Durapatite
Hydroxyapatite
Scaffolds
Bone
Bone and Bones
Bone Substitutes
Polymers
Computer-Aided Design
Forms (concrete)
Porosity
Medical imaging
Diagnostic Imaging
Cytotoxicity
Hemolysis
Biocompatibility
Pore size
Computer aided design

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomaterials
  • Biomedical Engineering

Cite this

Kwon, Byeong Ju ; Kim, Jungsung ; Kim, Yong Hwa ; Lee, Mi Hee ; Baek, Hyun Sook ; Lee, Dae Hyung ; Kim, Hye Lee ; Seo, Hyok Jin ; Lee, Min Hyeon ; Kwon, Soon Young ; Koo, Min Ah ; Park, Jongchul. / Biological advantages of porous hydroxyapatite scaffold made by solid freeform fabrication for bone tissue regeneration. In: Artificial Organs. 2013 ; Vol. 37, No. 7. pp. 663-670.
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Kwon, BJ, Kim, J, Kim, YH, Lee, MH, Baek, HS, Lee, DH, Kim, HL, Seo, HJ, Lee, MH, Kwon, SY, Koo, MA & Park, J 2013, 'Biological advantages of porous hydroxyapatite scaffold made by solid freeform fabrication for bone tissue regeneration', Artificial Organs, vol. 37, no. 7, pp. 663-670. https://doi.org/10.1111/aor.12047

Biological advantages of porous hydroxyapatite scaffold made by solid freeform fabrication for bone tissue regeneration. / Kwon, Byeong Ju; Kim, Jungsung; Kim, Yong Hwa; Lee, Mi Hee; Baek, Hyun Sook; Lee, Dae Hyung; Kim, Hye Lee; Seo, Hyok Jin; Lee, Min Hyeon; Kwon, Soon Young; Koo, Min Ah; Park, Jongchul.

In: Artificial Organs, Vol. 37, No. 7, 01.07.2013, p. 663-670.

Research output: Contribution to journalArticle

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AU - Baek, Hyun Sook

AU - Lee, Dae Hyung

AU - Kim, Hye Lee

AU - Seo, Hyok Jin

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AU - Kwon, Soon Young

AU - Koo, Min Ah

AU - Park, Jongchul

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N2 - Presently, commercially available porous bone substitutes are manufactured by the sacrificial template method, direct foaming method, and polymer replication method (PRM). However, current manufacturing methods provide only the simplest form of the bone scaffold and cannot easily control pore size. Recent developments in medical imaging technology, computer-aided design, and solid freeform fabrication (SFF), have made it possible to accurately produce porous synthetic bone scaffolds to fit the defected bone shape. Porous scaffolds were fabricated by SFF and PRM for a comparison of physical and mechanical properties of scaffold. The suggested three-dimensional model has interconnected cubic pores of 500μm and its calculated porosity is 25%. Whereas hydroxyapatite scaffolds fabricated by SFF had connective macropores, those by PRM formed a closed pore external surface with internally interconnected pores. SFF was supposed to be a proper method for fabricating an interconnected macroporous network. Biocompatibility was confirmed by testing the cytotoxicity, hemolysis, irritation, sensitization, and implantation. In summary, the aim was to verify the safety and efficacy of the scaffolds by biomechanical and biological tests with the hope that this research could promote the feasibility of using the scaffolds as a bone substitute.

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