Biological efficacy of two mineral trioxide aggregate (Mta)-based materials in a canine model of pulpotomy

Myeongyeon Lee, Chung Min Kang, Je Seon Song, Yoo Seok Shin, Seungh Ye Kim, Seong Oh Kim, Hyung Jun Choi

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


The aim of this study was to compare the biocompatibility of Endocem Zr® and ProRoot MTA® by histopathologic analysis in a canine model of pulpotomy. This study utilized 39 teeth of two beagle dogs. The exposed pulp tissues were treated by pulpotomy using ProRoot MTA (n=19) or Endocem Zr (n=20). After 8 weeks, the teeth were extracted and processed with hematoxylin-eosin staining for histologic evaluation. Most of the specimens in both groups developed a calcific barrier at the pulp amputation site and formed an odontoblast layer. However, some of the Endocem Zr specimens showed less calcific barrier formation with a greater inflammatory response and less odontoblast layer formation when compared with the ProRoot MTA specimens. ProRoot MTA and Endocem Zr specimens developed a calcific barrier; however, ProRoot MTA was more biocompatible than Endocem Zr.

Original languageEnglish
Article numberdmj/2016-121
Pages (from-to)41-47
Number of pages7
JournalDental Materials Journal
Issue number1
Publication statusPublished - 2017

Bibliographical note

Funding Information:
This study was supported by the Yonsei University College of Dentistry Fund (6-2014-0083). The authors deny any conflicts of interest related to this study.

Publisher Copyright:
© 2017, Japanese Society for Dental Materials and Devices. All rights reserved.

All Science Journal Classification (ASJC) codes

  • Ceramics and Composites
  • Dentistry(all)


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