Biological evaluation of indolizine-chalcone hybrids as new anticancer agents

Sujin Park, Eun Hye Kim, Jinwoo Kim, Seong Hwan Kim, Ikyon Kim

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

A new chemical space was explored based on an indolizine-chalcone hybrid, which was readily accessible by base-mediated aldol condensation of indolizine bearing a 7-acetyl group with various (hetero)aromatic aldehydes. Their anticancer effect was evaluated, revealing that indolizine-chalcone hybrids with 3,5-dimethoxyphenyl group (4h) or the halogen at the meta position (4j and 4l) could have the potential to induce the caspase-dependent apoptosis of human lymphoma cells.

Original languageEnglish
Pages (from-to)435-443
Number of pages9
JournalEuropean Journal of Medicinal Chemistry
Volume144
DOIs
Publication statusPublished - 2018 Jan 20

Fingerprint

Chalcone
Antineoplastic Agents
Bearings (structural)
Halogens
Caspases
Aldehydes
Condensation
Lymphoma
Apoptosis
indolizine

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery
  • Organic Chemistry

Cite this

Park, Sujin ; Kim, Eun Hye ; Kim, Jinwoo ; Kim, Seong Hwan ; Kim, Ikyon. / Biological evaluation of indolizine-chalcone hybrids as new anticancer agents. In: European Journal of Medicinal Chemistry. 2018 ; Vol. 144. pp. 435-443.
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Biological evaluation of indolizine-chalcone hybrids as new anticancer agents. / Park, Sujin; Kim, Eun Hye; Kim, Jinwoo; Kim, Seong Hwan; Kim, Ikyon.

In: European Journal of Medicinal Chemistry, Vol. 144, 20.01.2018, p. 435-443.

Research output: Contribution to journalArticle

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