Biomarker-specific conjugated nanopolyplexes for the active coloring of stem-like cancer cells

Yoochan Hong, Eugene Lee, Jihye Choi, Seungjoo Haam, Jinsuck Suh, Jaemoon Yang

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Stem-like cancer cells possess intrinsic features and their CD44 regulate redox balance in cancer cells to survive under stress conditions. Thus, we have fabricated biomarker-specific conjugated polyplexes using CD44-targetable hyaluronic acid and redox-sensible polyaniline based on a nanoemulsion method. For the most sensitive recognition of the cellular redox at a single nanoparticle scale, a nano-scattering spectrum imaging analyzer system was introduced. The conjugated polyplexes showed a specific targeting ability toward CD44-expressing cancer cells as well as a dramatic change in its color, which depended on the redox potential in the light-scattered images. Therefore, these polyaniline-based conjugated polyplexes as well as analytical processes that include light-scattering imaging and measurements of scattering spectra, clearly establish a systematic method for the detection and monitoring of cancer microenvironments.

Original languageEnglish
Article number225101
JournalNanotechnology
Volume27
Issue number22
DOIs
Publication statusPublished - 2016 Apr 21

Fingerprint

Biomarkers
Coloring
Cells
Polyaniline
Scattering
Imaging techniques
Hyaluronic acid
Hyaluronic Acid
Light scattering
Nanoparticles
Color
Oxidation-Reduction
Monitoring
polyaniline

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering
  • Electrical and Electronic Engineering

Cite this

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abstract = "Stem-like cancer cells possess intrinsic features and their CD44 regulate redox balance in cancer cells to survive under stress conditions. Thus, we have fabricated biomarker-specific conjugated polyplexes using CD44-targetable hyaluronic acid and redox-sensible polyaniline based on a nanoemulsion method. For the most sensitive recognition of the cellular redox at a single nanoparticle scale, a nano-scattering spectrum imaging analyzer system was introduced. The conjugated polyplexes showed a specific targeting ability toward CD44-expressing cancer cells as well as a dramatic change in its color, which depended on the redox potential in the light-scattered images. Therefore, these polyaniline-based conjugated polyplexes as well as analytical processes that include light-scattering imaging and measurements of scattering spectra, clearly establish a systematic method for the detection and monitoring of cancer microenvironments.",
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Biomarker-specific conjugated nanopolyplexes for the active coloring of stem-like cancer cells. / Hong, Yoochan; Lee, Eugene; Choi, Jihye; Haam, Seungjoo; Suh, Jinsuck; Yang, Jaemoon.

In: Nanotechnology, Vol. 27, No. 22, 225101, 21.04.2016.

Research output: Contribution to journalArticle

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AU - Hong, Yoochan

AU - Lee, Eugene

AU - Choi, Jihye

AU - Haam, Seungjoo

AU - Suh, Jinsuck

AU - Yang, Jaemoon

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AB - Stem-like cancer cells possess intrinsic features and their CD44 regulate redox balance in cancer cells to survive under stress conditions. Thus, we have fabricated biomarker-specific conjugated polyplexes using CD44-targetable hyaluronic acid and redox-sensible polyaniline based on a nanoemulsion method. For the most sensitive recognition of the cellular redox at a single nanoparticle scale, a nano-scattering spectrum imaging analyzer system was introduced. The conjugated polyplexes showed a specific targeting ability toward CD44-expressing cancer cells as well as a dramatic change in its color, which depended on the redox potential in the light-scattered images. Therefore, these polyaniline-based conjugated polyplexes as well as analytical processes that include light-scattering imaging and measurements of scattering spectra, clearly establish a systematic method for the detection and monitoring of cancer microenvironments.

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