Biomechanical simulation for cartilage regeneration of knee joint osteoarthritis with composite scaffold using ply angle optimization

Yong Gon Koh, Jin Ah Lee, Heoung Jae Chun, Kyoung Tak Kang

Research output: Contribution to journalArticle

Abstract

This study investigates the optimization of the ply angle for cartilage regeneration using a composite scaffold for treating knee joint osteoarthritis. We propose a new paradigm for composite scaffold tissue engineering that focuses on the reconstitution of the anatomic fiber architecture and uses constitutive modeling to evaluate the function of the construct. The mechano-regulation algorithm for tissue differentiation was used to determine the influence of the composite scaffold with an optimized ply angle on chondrogenesis in a computational model of knee-joint severe osteoarthritis. The simulation results revealed that the optimized ply-angle composite scaffold, which had similar mechanical properties to the native cartilage, provided the most appropriate biomechanical environment for cartilage regeneration.

Original languageEnglish
JournalJournal of Biomaterials Applications
DOIs
Publication statusAccepted/In press - 2019 Jan 1

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Cartilage
Scaffolds
Composite materials
Scaffolds (biology)
Tissue engineering
Tissue
Mechanical properties
Fibers

All Science Journal Classification (ASJC) codes

  • Biomaterials
  • Biomedical Engineering

Cite this

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