Abstract
This study investigates the optimization of the ply angle for cartilage regeneration using a composite scaffold for treating knee joint osteoarthritis. We propose a new paradigm for composite scaffold tissue engineering that focuses on the reconstitution of the anatomic fiber architecture and uses constitutive modeling to evaluate the function of the construct. The mechano-regulation algorithm for tissue differentiation was used to determine the influence of the composite scaffold with an optimized ply angle on chondrogenesis in a computational model of knee-joint severe osteoarthritis. The simulation results revealed that the optimized ply-angle composite scaffold, which had similar mechanical properties to the native cartilage, provided the most appropriate biomechanical environment for cartilage regeneration.
Original language | English |
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Pages (from-to) | 1019-1027 |
Number of pages | 9 |
Journal | Journal of Biomaterials Applications |
Volume | 34 |
Issue number | 7 |
DOIs | |
Publication status | Published - 2020 Feb 1 |
Bibliographical note
Publisher Copyright:© The Author(s) 2019.
All Science Journal Classification (ASJC) codes
- Biomaterials
- Biomedical Engineering