Abstract
This study investigates the optimization of the ply angle for cartilage regeneration using a composite scaffold for treating knee joint osteoarthritis. We propose a new paradigm for composite scaffold tissue engineering that focuses on the reconstitution of the anatomic fiber architecture and uses constitutive modeling to evaluate the function of the construct. The mechano-regulation algorithm for tissue differentiation was used to determine the influence of the composite scaffold with an optimized ply angle on chondrogenesis in a computational model of knee-joint severe osteoarthritis. The simulation results revealed that the optimized ply-angle composite scaffold, which had similar mechanical properties to the native cartilage, provided the most appropriate biomechanical environment for cartilage regeneration.
| Original language | English |
|---|---|
| Journal | Journal of Biomaterials Applications |
| DOIs | |
| Publication status | Accepted/In press - 2019 Jan 1 |
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All Science Journal Classification (ASJC) codes
- Biomaterials
- Biomedical Engineering
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Biomechanical simulation for cartilage regeneration of knee joint osteoarthritis with composite scaffold using ply angle optimization. / Koh, Yong Gon; Lee, Jin Ah; Chun, Heoung Jae; Kang, Kyoung Tak.
In: Journal of Biomaterials Applications, 01.01.2019.Research output: Contribution to journal › Article
TY - JOUR
T1 - Biomechanical simulation for cartilage regeneration of knee joint osteoarthritis with composite scaffold using ply angle optimization
AU - Koh, Yong Gon
AU - Lee, Jin Ah
AU - Chun, Heoung Jae
AU - Kang, Kyoung Tak
PY - 2019/1/1
Y1 - 2019/1/1
N2 - This study investigates the optimization of the ply angle for cartilage regeneration using a composite scaffold for treating knee joint osteoarthritis. We propose a new paradigm for composite scaffold tissue engineering that focuses on the reconstitution of the anatomic fiber architecture and uses constitutive modeling to evaluate the function of the construct. The mechano-regulation algorithm for tissue differentiation was used to determine the influence of the composite scaffold with an optimized ply angle on chondrogenesis in a computational model of knee-joint severe osteoarthritis. The simulation results revealed that the optimized ply-angle composite scaffold, which had similar mechanical properties to the native cartilage, provided the most appropriate biomechanical environment for cartilage regeneration.
AB - This study investigates the optimization of the ply angle for cartilage regeneration using a composite scaffold for treating knee joint osteoarthritis. We propose a new paradigm for composite scaffold tissue engineering that focuses on the reconstitution of the anatomic fiber architecture and uses constitutive modeling to evaluate the function of the construct. The mechano-regulation algorithm for tissue differentiation was used to determine the influence of the composite scaffold with an optimized ply angle on chondrogenesis in a computational model of knee-joint severe osteoarthritis. The simulation results revealed that the optimized ply-angle composite scaffold, which had similar mechanical properties to the native cartilage, provided the most appropriate biomechanical environment for cartilage regeneration.
UR - http://www.scopus.com/inward/record.url?scp=85075357468&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85075357468&partnerID=8YFLogxK
U2 - 10.1177/0885328219886195
DO - 10.1177/0885328219886195
M3 - Article
C2 - 31739728
AN - SCOPUS:85075357468
JO - Journal of Biomaterials Applications
JF - Journal of Biomaterials Applications
SN - 0885-3282
ER -