Biomolecular corona on nanoparticles: A survey of recent literature and its implications in targeted drug delivery

Ryan M. Pearson; Vanessa V. Juettner; Seungpyo Hong

doi:10.3389/fchem.2014.00108

Biomolecular corona on nanoparticles: A survey of recent literature and its implications in targeted drug delivery

Ryan M. Pearson, Vanessa V. Juettner, Seungpyo Hong

Department of Pharmacy

Research output: Contribution to journal › Short survey › peer-review

78 Citations (Scopus)

Abstract

Achieving controlled cellular responses of nanoparticles (NP) is critical for the successful development and translation of NP-based drug delivery systems. However, precise control over the physicochemical and biological properties of NPs could become convoluted, diminished, or completely lost as a result of the adsorption of biomolecules to their surfaces. Characterization of the formation of the "biomolecular" corona has thus received increased attention due to its impact on NP and protein structure as well as its negative effect on NP-based targeted drug delivery. This review presents a concise survey of the recent literature concerning the importance of the NP-biomolecule corona and how it can be utilized to improve the in vivo efficacy of targeted delivery systems.

Original language	English
Article number	108
Journal	Frontiers in Chemistry
Volume	2
Issue number	NOV
DOIs	https://doi.org/10.3389/fchem.2014.00108
Publication status	Published - 2014

Bibliographical note

Funding Information:
This work was partially supported by National Science Foundation (NSF) under the grant # DMR-1409161 and National Cancer Institute (NCI) under the grant # R01 CA182580-01. Ryan M. Pearson also acknowledges partial support from the Dean's Scholarship of UIC for his graduate education.

All Science Journal Classification (ASJC) codes

Chemistry(all)

Access to Document

10.3389/fchem.2014.00108

Fingerprint Dive into the research topics of 'Biomolecular corona on nanoparticles: A survey of recent literature and its implications in targeted drug delivery'. Together they form a unique fingerprint.

Cite this

@article{8cd8826e6f774f77b596d999fbe4911e,

title = "Biomolecular corona on nanoparticles: A survey of recent literature and its implications in targeted drug delivery",

abstract = "Achieving controlled cellular responses of nanoparticles (NP) is critical for the successful development and translation of NP-based drug delivery systems. However, precise control over the physicochemical and biological properties of NPs could become convoluted, diminished, or completely lost as a result of the adsorption of biomolecules to their surfaces. Characterization of the formation of the {"}biomolecular{"} corona has thus received increased attention due to its impact on NP and protein structure as well as its negative effect on NP-based targeted drug delivery. This review presents a concise survey of the recent literature concerning the importance of the NP-biomolecule corona and how it can be utilized to improve the in vivo efficacy of targeted delivery systems.",

author = "Pearson, {Ryan M.} and Juettner, {Vanessa V.} and Seungpyo Hong",

note = "Funding Information: This work was partially supported by National Science Foundation (NSF) under the grant # DMR-1409161 and National Cancer Institute (NCI) under the grant # R01 CA182580-01. Ryan M. Pearson also acknowledges partial support from the Dean's Scholarship of UIC for his graduate education.",

year = "2014",

doi = "10.3389/fchem.2014.00108",

language = "English",

volume = "2",

journal = "Frontiers in Chemistry",

issn = "2296-2646",

publisher = "Frontiers Media S. A.",

number = "NOV",

}

TY - JOUR

T1 - Biomolecular corona on nanoparticles

T2 - A survey of recent literature and its implications in targeted drug delivery

AU - Pearson, Ryan M.

AU - Juettner, Vanessa V.

AU - Hong, Seungpyo

N1 - Funding Information: This work was partially supported by National Science Foundation (NSF) under the grant # DMR-1409161 and National Cancer Institute (NCI) under the grant # R01 CA182580-01. Ryan M. Pearson also acknowledges partial support from the Dean's Scholarship of UIC for his graduate education.

PY - 2014

Y1 - 2014

N2 - Achieving controlled cellular responses of nanoparticles (NP) is critical for the successful development and translation of NP-based drug delivery systems. However, precise control over the physicochemical and biological properties of NPs could become convoluted, diminished, or completely lost as a result of the adsorption of biomolecules to their surfaces. Characterization of the formation of the "biomolecular" corona has thus received increased attention due to its impact on NP and protein structure as well as its negative effect on NP-based targeted drug delivery. This review presents a concise survey of the recent literature concerning the importance of the NP-biomolecule corona and how it can be utilized to improve the in vivo efficacy of targeted delivery systems.

AB - Achieving controlled cellular responses of nanoparticles (NP) is critical for the successful development and translation of NP-based drug delivery systems. However, precise control over the physicochemical and biological properties of NPs could become convoluted, diminished, or completely lost as a result of the adsorption of biomolecules to their surfaces. Characterization of the formation of the "biomolecular" corona has thus received increased attention due to its impact on NP and protein structure as well as its negative effect on NP-based targeted drug delivery. This review presents a concise survey of the recent literature concerning the importance of the NP-biomolecule corona and how it can be utilized to improve the in vivo efficacy of targeted delivery systems.

UR - http://www.scopus.com/inward/record.url?scp=84987638579&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84987638579&partnerID=8YFLogxK

U2 - 10.3389/fchem.2014.00108

DO - 10.3389/fchem.2014.00108

M3 - Short survey

AN - SCOPUS:84987638579

VL - 2

JO - Frontiers in Chemistry

JF - Frontiers in Chemistry

SN - 2296-2646

IS - NOV

M1 - 108

ER -