TY - JOUR
T1 - Biomolecular corona on nanoparticles
T2 - A survey of recent literature and its implications in targeted drug delivery
AU - Pearson, Ryan M.
AU - Juettner, Vanessa V.
AU - Hong, Seungpyo
PY - 2014
Y1 - 2014
N2 - Achieving controlled cellular responses of nanoparticles (NP) is critical for the successful development and translation of NP-based drug delivery systems. However, precise control over the physicochemical and biological properties of NPs could become convoluted, diminished, or completely lost as a result of the adsorption of biomolecules to their surfaces. Characterization of the formation of the "biomolecular" corona has thus received increased attention due to its impact on NP and protein structure as well as its negative effect on NP-based targeted drug delivery. This review presents a concise survey of the recent literature concerning the importance of the NP-biomolecule corona and how it can be utilized to improve the in vivo efficacy of targeted delivery systems.
AB - Achieving controlled cellular responses of nanoparticles (NP) is critical for the successful development and translation of NP-based drug delivery systems. However, precise control over the physicochemical and biological properties of NPs could become convoluted, diminished, or completely lost as a result of the adsorption of biomolecules to their surfaces. Characterization of the formation of the "biomolecular" corona has thus received increased attention due to its impact on NP and protein structure as well as its negative effect on NP-based targeted drug delivery. This review presents a concise survey of the recent literature concerning the importance of the NP-biomolecule corona and how it can be utilized to improve the in vivo efficacy of targeted delivery systems.
UR - http://www.scopus.com/inward/record.url?scp=84987638579&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84987638579&partnerID=8YFLogxK
U2 - 10.3389/fchem.2014.00108
DO - 10.3389/fchem.2014.00108
M3 - Short survey
AN - SCOPUS:84987638579
VL - 2
JO - Frontiers in Chemistry
JF - Frontiers in Chemistry
SN - 2296-2646
IS - NOV
M1 - 108
ER -