Bioresorbable pressure sensors protected with thermally grown silicon dioxide for the monitoring of chronic diseases and healing processes

Jiho Shin, Ying Yan, Wubin Bai, Yeguang Xue, Paul Gamble, Limei Tian, Irawati Kandela, Chad R. Haney, William Spees, Yechan Lee, Minseok Choi, Jonathan Ko, Hangyu Ryu, Jan Kai Chang, Maryam Pezhouh, Seung Kyun Kang, Sang Min Won, Ki Jun Yu, Jianing Zhao, Yoon Kyeung LeeMatthew R. MacEwan, Sheng Kwei Song, Yonggang Huang, Wilson Z. Ray, John A. Rogers

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Pressures in the intracranial, intraocular and intravascular spaces are clinically useful for the diagnosis and management of traumatic brain injury, glaucoma and hypertension, respectively. Conventional devices for measuring these pressures require surgical extraction after a relevant operational time frame. Bioresorbable sensors, by contrast, eliminate this requirement, thereby minimizing the risk of infection, decreasing the costs of care and reducing distress and pain for the patient. However, the operational lifetimes of bioresorbable pressure sensors available at present fall short of many clinical needs. Here, we present materials, device structures and fabrication procedures for bioresorbable pressure sensors with lifetimes exceeding those of previous reports by at least tenfold. We demonstrate measurement accuracies that compare favourably to those of the most sophisticated clinical standards for non-resorbable devices by monitoring intracranial pressures in rats for 25 days. Assessments of the biodistribution of the constituent materials, complete blood counts, blood chemistry and magnetic resonance imaging compatibility confirm the biodegradability and clinical utility of the device. Our findings establish routes for the design and fabrication of bioresorbable pressure monitors that meet requirements for clinical use.

Original languageEnglish
Pages (from-to)37-46
Number of pages10
JournalNature biomedical engineering
Volume3
Issue number1
DOIs
Publication statusPublished - 2019 Jan 1

    Fingerprint

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Bioengineering
  • Medicine (miscellaneous)
  • Biomedical Engineering
  • Computer Science Applications

Cite this

Shin, J., Yan, Y., Bai, W., Xue, Y., Gamble, P., Tian, L., Kandela, I., Haney, C. R., Spees, W., Lee, Y., Choi, M., Ko, J., Ryu, H., Chang, J. K., Pezhouh, M., Kang, S. K., Won, S. M., Yu, K. J., Zhao, J., ... Rogers, J. A. (2019). Bioresorbable pressure sensors protected with thermally grown silicon dioxide for the monitoring of chronic diseases and healing processes. Nature biomedical engineering, 3(1), 37-46. https://doi.org/10.1038/s41551-018-0300-4