The detection of biotin-streptavidin binding was demonstrated by the resonance frequency measurement of a simple resonance circuit using graphene oxide dielectric. The resonance frequency was decreased to the lower frequency range as biotin and streptavidin were bound to the graphene oxide film. Graphene oxide dielectric provides dual advantages including quality-factor enhancement and high affinity for bio sensing. It was revealed that an increase in capacitance of the graphene oxide sheet was mainly responsible for the resonance frequency shift. The sensitivity to the capacitance change in the frequency-based detection technique can enable the advanced biosensing applications using graphene oxide sheet.
Bibliographical noteFunding Information:
This research was partially supported by the Priority Research Centers Program (2012-8-1663), the Pioneer Research Center Program (2012-0000428), and the Basic Science Research Program (2012-8-0622) through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (MEST) of the Korean government.
All Science Journal Classification (ASJC) codes
- Physics and Astronomy (miscellaneous)