Biotin-streptavidin detection with a graphene-oxide supported radio-frequency resonator

Hyong Seo Yoon, Juhwan Lim, Sang Uk Son, Duck Hwan Kim, Insang Song, Seong Chan Jun

Research output: Contribution to journalArticle

5 Citations (Scopus)


The detection of biotin-streptavidin binding was demonstrated by the resonance frequency measurement of a simple resonance circuit using graphene oxide dielectric. The resonance frequency was decreased to the lower frequency range as biotin and streptavidin were bound to the graphene oxide film. Graphene oxide dielectric provides dual advantages including quality-factor enhancement and high affinity for bio sensing. It was revealed that an increase in capacitance of the graphene oxide sheet was mainly responsible for the resonance frequency shift. The sensitivity to the capacitance change in the frequency-based detection technique can enable the advanced biosensing applications using graphene oxide sheet.

Original languageEnglish
Article number193701
JournalApplied Physics Letters
Issue number19
Publication statusPublished - 2013 May 13

All Science Journal Classification (ASJC) codes

  • Physics and Astronomy (miscellaneous)

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