Black Phosphorus Nanoparticle Labels for Immunoassays via Hydrogen Evolution Reaction Mediation

Carmen C. Mayorga-Martinez; Naziah Mohamad Latiff; Alex Yong Sheng Eng; Zdeněk Sofer; Martin Pumera

doi:10.1021/acs.analchem.6b02422

Black Phosphorus Nanoparticle Labels for Immunoassays via Hydrogen Evolution Reaction Mediation

Carmen C. Mayorga-Martinez, Naziah Mohamad Latiff, Alex Yong Sheng Eng, Zdeněk Sofer, Martin Pumera

Department of Chemical and Biomolecular Engineering

Research output: Contribution to journal › Article › peer-review

87 Citations (Scopus)

Abstract

Black phosphorus is an emerging layered material. Its nanoparticles show an increased bandgap when compared to bulk materials and they are typically fabricated by ultrasonication of macroscopic black phosphorus crystals. Here we fabricate black phosphorus nanoparticles (BP NPs) by solution based electrochemical exfoliation with bipolar electrodes, which induces opposite potentials on the opposite ends of black phosphorus macroparticles thereby leading to its decomposition into nanoparticles. BP NPs have enhanced catalytic effect on the hydrogen evolution reaction (HER) relative to black phosphorus macroparticles. We utilize black phosphorus nanoparticles as electrocatalytic tags in a competitive immunoassay for rabbit immunoglobulin G (IgG) detection. The detection signal is produced via nanoimpacts of the BP NPs followed by HER catalysis.

Original language	English
Pages (from-to)	10074-10079
Number of pages	6
Journal	Analytical Chemistry
Volume	88
Issue number	20
DOIs	https://doi.org/10.1021/acs.analchem.6b02422
Publication status	Published - 2016 Oct 18

Bibliographical note

Funding Information:
M.P. was supported by Tier 2 grant (Grant MOE2013-T2-1-056; ARC 35/13) from the Ministry of Education, Singapore. Z.S. was supported by the Czech Science Foundation (GACR Grant No. 15-09001S).

Publisher Copyright:
© 2016 American Chemical Society.

All Science Journal Classification (ASJC) codes

Analytical Chemistry

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10.1021/acs.analchem.6b02422

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title = "Black Phosphorus Nanoparticle Labels for Immunoassays via Hydrogen Evolution Reaction Mediation",

abstract = "Black phosphorus is an emerging layered material. Its nanoparticles show an increased bandgap when compared to bulk materials and they are typically fabricated by ultrasonication of macroscopic black phosphorus crystals. Here we fabricate black phosphorus nanoparticles (BP NPs) by solution based electrochemical exfoliation with bipolar electrodes, which induces opposite potentials on the opposite ends of black phosphorus macroparticles thereby leading to its decomposition into nanoparticles. BP NPs have enhanced catalytic effect on the hydrogen evolution reaction (HER) relative to black phosphorus macroparticles. We utilize black phosphorus nanoparticles as electrocatalytic tags in a competitive immunoassay for rabbit immunoglobulin G (IgG) detection. The detection signal is produced via nanoimpacts of the BP NPs followed by HER catalysis.",

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AU - Sofer, Zdeněk

AU - Pumera, Martin

N1 - Funding Information: M.P. was supported by Tier 2 grant (Grant MOE2013-T2-1-056; ARC 35/13) from the Ministry of Education, Singapore. Z.S. was supported by the Czech Science Foundation (GACR Grant No. 15-09001S). Publisher Copyright: © 2016 American Chemical Society.

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AB - Black phosphorus is an emerging layered material. Its nanoparticles show an increased bandgap when compared to bulk materials and they are typically fabricated by ultrasonication of macroscopic black phosphorus crystals. Here we fabricate black phosphorus nanoparticles (BP NPs) by solution based electrochemical exfoliation with bipolar electrodes, which induces opposite potentials on the opposite ends of black phosphorus macroparticles thereby leading to its decomposition into nanoparticles. BP NPs have enhanced catalytic effect on the hydrogen evolution reaction (HER) relative to black phosphorus macroparticles. We utilize black phosphorus nanoparticles as electrocatalytic tags in a competitive immunoassay for rabbit immunoglobulin G (IgG) detection. The detection signal is produced via nanoimpacts of the BP NPs followed by HER catalysis.

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Black Phosphorus Nanoparticle Labels for Immunoassays via Hydrogen Evolution Reaction Mediation

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

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