Blood lead levels and cause-specific mortality of inorganic lead-exposed workers in South Korea

Min Gi Kim, Jae Hong Ryoo, Se Jin Chang, Chun Bae Kim, Jong Ku Park, Sangbaek Koh, Yeon Soon Ahn

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The objective of this study was to identify the association of blood lead level (BLL) with mortalityin inorganic lead-exposed workers of South Korea. A cohort was compiled comprising 81,067 inorganic lead exposed workers working between January 1, 2000, and December31, 2004. This cohort was merged with the Korean National Statistical Office to follow-up for mortality between 2000 and 2008. After adjusting for age and other carcinogenic metalexposure, all-cause mortality (Relative risk [RR] 1.36, 95% confidence interval [CI] 1.03- 1.79), digestive disease (RR 3.23, 95% CI 1.33-7.86), and intentional self-harm (RR 2.92, 95% CI 1.07-7.81) were statistically significantly higher in males with BLL >20 μg/dl than of those with BLL ≤10μg/dl. The RR of males with BLL of 10-20 μg/dl was statistically higherthan of those with BLL ≤10μg/dl in infection (RR 3.73. 95% CI, 1.06-13.06). The RRs of females with 10-20 μg/dl BLL was statistically significantly greater than those with BLL<10μg/dl in all-cause mortality (RR 1.93, 95% CI 1.16-3.20) and colon and rectal cancer (RR 13.42, 95% CI 1.21-149.4). The RRs of females with BLL 10-20 μg/dl (RR 10.45, 95%CI 1.74-62.93) and BLL ≥20 μg/dl (RR 12.68, 95% CI 1.69-147.86) was statistically significantly increased in bronchus and lung cancer. The increased suicide of males with ≥20 μg/dl BLLs, which might be caused by major depression, might be associated with higher lead exposure. Also, increased bronchus and lung cancer mortality in female workers with higherBLL might be related to lead exposure considering low smoking rate in females. The kinds of BLL-associated mortality differed by gender.

Original languageEnglish
Article numbere0140360
JournalPloS one
Volume10
Issue number10
DOIs
Publication statusPublished - 2015 Oct 15

Fingerprint

Republic of Korea
South Korea
Blood
relative risk
Mortality
blood
confidence interval
Confidence Intervals
bronchi
Bronchi
lung neoplasms
colorectal neoplasms
Lead
Lung Neoplasms
suicide
Rectal Neoplasms
digestive system diseases
Colonic Neoplasms
Suicide

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Kim, M. G., Ryoo, J. H., Chang, S. J., Kim, C. B., Park, J. K., Koh, S., & Ahn, Y. S. (2015). Blood lead levels and cause-specific mortality of inorganic lead-exposed workers in South Korea. PloS one, 10(10), [e0140360]. https://doi.org/10.1371/journal.pone.0140360
Kim, Min Gi ; Ryoo, Jae Hong ; Chang, Se Jin ; Kim, Chun Bae ; Park, Jong Ku ; Koh, Sangbaek ; Ahn, Yeon Soon. / Blood lead levels and cause-specific mortality of inorganic lead-exposed workers in South Korea. In: PloS one. 2015 ; Vol. 10, No. 10.
@article{721d73182203415f84d36064c85baaec,
title = "Blood lead levels and cause-specific mortality of inorganic lead-exposed workers in South Korea",
abstract = "The objective of this study was to identify the association of blood lead level (BLL) with mortalityin inorganic lead-exposed workers of South Korea. A cohort was compiled comprising 81,067 inorganic lead exposed workers working between January 1, 2000, and December31, 2004. This cohort was merged with the Korean National Statistical Office to follow-up for mortality between 2000 and 2008. After adjusting for age and other carcinogenic metalexposure, all-cause mortality (Relative risk [RR] 1.36, 95{\%} confidence interval [CI] 1.03- 1.79), digestive disease (RR 3.23, 95{\%} CI 1.33-7.86), and intentional self-harm (RR 2.92, 95{\%} CI 1.07-7.81) were statistically significantly higher in males with BLL >20 μg/dl than of those with BLL ≤10μg/dl. The RR of males with BLL of 10-20 μg/dl was statistically higherthan of those with BLL ≤10μg/dl in infection (RR 3.73. 95{\%} CI, 1.06-13.06). The RRs of females with 10-20 μg/dl BLL was statistically significantly greater than those with BLL<10μg/dl in all-cause mortality (RR 1.93, 95{\%} CI 1.16-3.20) and colon and rectal cancer (RR 13.42, 95{\%} CI 1.21-149.4). The RRs of females with BLL 10-20 μg/dl (RR 10.45, 95{\%}CI 1.74-62.93) and BLL ≥20 μg/dl (RR 12.68, 95{\%} CI 1.69-147.86) was statistically significantly increased in bronchus and lung cancer. The increased suicide of males with ≥20 μg/dl BLLs, which might be caused by major depression, might be associated with higher lead exposure. Also, increased bronchus and lung cancer mortality in female workers with higherBLL might be related to lead exposure considering low smoking rate in females. The kinds of BLL-associated mortality differed by gender.",
author = "Kim, {Min Gi} and Ryoo, {Jae Hong} and Chang, {Se Jin} and Kim, {Chun Bae} and Park, {Jong Ku} and Sangbaek Koh and Ahn, {Yeon Soon}",
year = "2015",
month = "10",
day = "15",
doi = "10.1371/journal.pone.0140360",
language = "English",
volume = "10",
journal = "PLoS One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "10",

}

Blood lead levels and cause-specific mortality of inorganic lead-exposed workers in South Korea. / Kim, Min Gi; Ryoo, Jae Hong; Chang, Se Jin; Kim, Chun Bae; Park, Jong Ku; Koh, Sangbaek; Ahn, Yeon Soon.

In: PloS one, Vol. 10, No. 10, e0140360, 15.10.2015.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Blood lead levels and cause-specific mortality of inorganic lead-exposed workers in South Korea

AU - Kim, Min Gi

AU - Ryoo, Jae Hong

AU - Chang, Se Jin

AU - Kim, Chun Bae

AU - Park, Jong Ku

AU - Koh, Sangbaek

AU - Ahn, Yeon Soon

PY - 2015/10/15

Y1 - 2015/10/15

N2 - The objective of this study was to identify the association of blood lead level (BLL) with mortalityin inorganic lead-exposed workers of South Korea. A cohort was compiled comprising 81,067 inorganic lead exposed workers working between January 1, 2000, and December31, 2004. This cohort was merged with the Korean National Statistical Office to follow-up for mortality between 2000 and 2008. After adjusting for age and other carcinogenic metalexposure, all-cause mortality (Relative risk [RR] 1.36, 95% confidence interval [CI] 1.03- 1.79), digestive disease (RR 3.23, 95% CI 1.33-7.86), and intentional self-harm (RR 2.92, 95% CI 1.07-7.81) were statistically significantly higher in males with BLL >20 μg/dl than of those with BLL ≤10μg/dl. The RR of males with BLL of 10-20 μg/dl was statistically higherthan of those with BLL ≤10μg/dl in infection (RR 3.73. 95% CI, 1.06-13.06). The RRs of females with 10-20 μg/dl BLL was statistically significantly greater than those with BLL<10μg/dl in all-cause mortality (RR 1.93, 95% CI 1.16-3.20) and colon and rectal cancer (RR 13.42, 95% CI 1.21-149.4). The RRs of females with BLL 10-20 μg/dl (RR 10.45, 95%CI 1.74-62.93) and BLL ≥20 μg/dl (RR 12.68, 95% CI 1.69-147.86) was statistically significantly increased in bronchus and lung cancer. The increased suicide of males with ≥20 μg/dl BLLs, which might be caused by major depression, might be associated with higher lead exposure. Also, increased bronchus and lung cancer mortality in female workers with higherBLL might be related to lead exposure considering low smoking rate in females. The kinds of BLL-associated mortality differed by gender.

AB - The objective of this study was to identify the association of blood lead level (BLL) with mortalityin inorganic lead-exposed workers of South Korea. A cohort was compiled comprising 81,067 inorganic lead exposed workers working between January 1, 2000, and December31, 2004. This cohort was merged with the Korean National Statistical Office to follow-up for mortality between 2000 and 2008. After adjusting for age and other carcinogenic metalexposure, all-cause mortality (Relative risk [RR] 1.36, 95% confidence interval [CI] 1.03- 1.79), digestive disease (RR 3.23, 95% CI 1.33-7.86), and intentional self-harm (RR 2.92, 95% CI 1.07-7.81) were statistically significantly higher in males with BLL >20 μg/dl than of those with BLL ≤10μg/dl. The RR of males with BLL of 10-20 μg/dl was statistically higherthan of those with BLL ≤10μg/dl in infection (RR 3.73. 95% CI, 1.06-13.06). The RRs of females with 10-20 μg/dl BLL was statistically significantly greater than those with BLL<10μg/dl in all-cause mortality (RR 1.93, 95% CI 1.16-3.20) and colon and rectal cancer (RR 13.42, 95% CI 1.21-149.4). The RRs of females with BLL 10-20 μg/dl (RR 10.45, 95%CI 1.74-62.93) and BLL ≥20 μg/dl (RR 12.68, 95% CI 1.69-147.86) was statistically significantly increased in bronchus and lung cancer. The increased suicide of males with ≥20 μg/dl BLLs, which might be caused by major depression, might be associated with higher lead exposure. Also, increased bronchus and lung cancer mortality in female workers with higherBLL might be related to lead exposure considering low smoking rate in females. The kinds of BLL-associated mortality differed by gender.

UR - http://www.scopus.com/inward/record.url?scp=84948948073&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84948948073&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0140360

DO - 10.1371/journal.pone.0140360

M3 - Article

VL - 10

JO - PLoS One

JF - PLoS One

SN - 1932-6203

IS - 10

M1 - e0140360

ER -