Abstract
The objective of this study was to identify the association of blood lead level (BLL) with mortalityin inorganic lead-exposed workers of South Korea. A cohort was compiled comprising 81,067 inorganic lead exposed workers working between January 1, 2000, and December31, 2004. This cohort was merged with the Korean National Statistical Office to follow-up for mortality between 2000 and 2008. After adjusting for age and other carcinogenic metalexposure, all-cause mortality (Relative risk [RR] 1.36, 95% confidence interval [CI] 1.03- 1.79), digestive disease (RR 3.23, 95% CI 1.33-7.86), and intentional self-harm (RR 2.92, 95% CI 1.07-7.81) were statistically significantly higher in males with BLL >20 μg/dl than of those with BLL ≤10μg/dl. The RR of males with BLL of 10-20 μg/dl was statistically higherthan of those with BLL ≤10μg/dl in infection (RR 3.73. 95% CI, 1.06-13.06). The RRs of females with 10-20 μg/dl BLL was statistically significantly greater than those with BLL<10μg/dl in all-cause mortality (RR 1.93, 95% CI 1.16-3.20) and colon and rectal cancer (RR 13.42, 95% CI 1.21-149.4). The RRs of females with BLL 10-20 μg/dl (RR 10.45, 95%CI 1.74-62.93) and BLL ≥20 μg/dl (RR 12.68, 95% CI 1.69-147.86) was statistically significantly increased in bronchus and lung cancer. The increased suicide of males with ≥20 μg/dl BLLs, which might be caused by major depression, might be associated with higher lead exposure. Also, increased bronchus and lung cancer mortality in female workers with higherBLL might be related to lead exposure considering low smoking rate in females. The kinds of BLL-associated mortality differed by gender.
| Original language | English |
|---|---|
| Article number | e0140360 |
| Journal | PloS one |
| Volume | 10 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - 2015 Oct 15 |
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All Science Journal Classification (ASJC) codes
- Biochemistry, Genetics and Molecular Biology(all)
- Agricultural and Biological Sciences(all)
- General
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Blood lead levels and cause-specific mortality of inorganic lead-exposed workers in South Korea. / Kim, Min Gi; Ryoo, Jae Hong; Chang, Se Jin; Kim, Chun Bae; Park, Jong Ku; Koh, Sang Baek; Ahn, Yeon Soon.
In: PloS one, Vol. 10, No. 10, e0140360, 15.10.2015.Research output: Contribution to journal › Article
TY - JOUR
T1 - Blood lead levels and cause-specific mortality of inorganic lead-exposed workers in South Korea
AU - Kim, Min Gi
AU - Ryoo, Jae Hong
AU - Chang, Se Jin
AU - Kim, Chun Bae
AU - Park, Jong Ku
AU - Koh, Sang Baek
AU - Ahn, Yeon Soon
PY - 2015/10/15
Y1 - 2015/10/15
N2 - The objective of this study was to identify the association of blood lead level (BLL) with mortalityin inorganic lead-exposed workers of South Korea. A cohort was compiled comprising 81,067 inorganic lead exposed workers working between January 1, 2000, and December31, 2004. This cohort was merged with the Korean National Statistical Office to follow-up for mortality between 2000 and 2008. After adjusting for age and other carcinogenic metalexposure, all-cause mortality (Relative risk [RR] 1.36, 95% confidence interval [CI] 1.03- 1.79), digestive disease (RR 3.23, 95% CI 1.33-7.86), and intentional self-harm (RR 2.92, 95% CI 1.07-7.81) were statistically significantly higher in males with BLL >20 μg/dl than of those with BLL ≤10μg/dl. The RR of males with BLL of 10-20 μg/dl was statistically higherthan of those with BLL ≤10μg/dl in infection (RR 3.73. 95% CI, 1.06-13.06). The RRs of females with 10-20 μg/dl BLL was statistically significantly greater than those with BLL<10μg/dl in all-cause mortality (RR 1.93, 95% CI 1.16-3.20) and colon and rectal cancer (RR 13.42, 95% CI 1.21-149.4). The RRs of females with BLL 10-20 μg/dl (RR 10.45, 95%CI 1.74-62.93) and BLL ≥20 μg/dl (RR 12.68, 95% CI 1.69-147.86) was statistically significantly increased in bronchus and lung cancer. The increased suicide of males with ≥20 μg/dl BLLs, which might be caused by major depression, might be associated with higher lead exposure. Also, increased bronchus and lung cancer mortality in female workers with higherBLL might be related to lead exposure considering low smoking rate in females. The kinds of BLL-associated mortality differed by gender.
AB - The objective of this study was to identify the association of blood lead level (BLL) with mortalityin inorganic lead-exposed workers of South Korea. A cohort was compiled comprising 81,067 inorganic lead exposed workers working between January 1, 2000, and December31, 2004. This cohort was merged with the Korean National Statistical Office to follow-up for mortality between 2000 and 2008. After adjusting for age and other carcinogenic metalexposure, all-cause mortality (Relative risk [RR] 1.36, 95% confidence interval [CI] 1.03- 1.79), digestive disease (RR 3.23, 95% CI 1.33-7.86), and intentional self-harm (RR 2.92, 95% CI 1.07-7.81) were statistically significantly higher in males with BLL >20 μg/dl than of those with BLL ≤10μg/dl. The RR of males with BLL of 10-20 μg/dl was statistically higherthan of those with BLL ≤10μg/dl in infection (RR 3.73. 95% CI, 1.06-13.06). The RRs of females with 10-20 μg/dl BLL was statistically significantly greater than those with BLL<10μg/dl in all-cause mortality (RR 1.93, 95% CI 1.16-3.20) and colon and rectal cancer (RR 13.42, 95% CI 1.21-149.4). The RRs of females with BLL 10-20 μg/dl (RR 10.45, 95%CI 1.74-62.93) and BLL ≥20 μg/dl (RR 12.68, 95% CI 1.69-147.86) was statistically significantly increased in bronchus and lung cancer. The increased suicide of males with ≥20 μg/dl BLLs, which might be caused by major depression, might be associated with higher lead exposure. Also, increased bronchus and lung cancer mortality in female workers with higherBLL might be related to lead exposure considering low smoking rate in females. The kinds of BLL-associated mortality differed by gender.
UR - http://www.scopus.com/inward/record.url?scp=84948948073&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84948948073&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0140360
DO - 10.1371/journal.pone.0140360
M3 - Article
C2 - 26469177
AN - SCOPUS:84948948073
VL - 10
JO - PLoS One
JF - PLoS One
SN - 1932-6203
IS - 10
M1 - e0140360
ER -