Blood pressure-lowering effect of Korean red ginseng associated with decreased circulating Lp-PLA 2 activity and lysophosphatidylcholines and increased dihydrobiopterin level in prehypertensive subjects

Tae Woong Cha, Minjoo Kim, Minkyung Kim, Jey Sook Chae, Jong Ho Lee

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

We evaluated the effects of red ginseng consumption on blood pressure (BP) and the fasting plasma metabolome. This randomized, double-blind, placebo-controlled study included nonobese, nondiabetic, prehypertensive subjects consuming 10 capsules daily containing 5 g red ginseng (n=31) or placebo (n=31). Fasting plasma metabolome profiles were obtained using ultra performance liquid chromatography-linear trap quadrupole Orbitrap MS. After 12 weeks, participants consuming red ginseng showed reductions of 6.5 and 5.0 mm Hg in systolic and diastolic BP, respectively. Compared with controls, those consuming red ginseng showed greater reductions in changed values of systolic BP, diastolic BP and lipoprotein-associated phospholipase A 2 (Lp-PLA 2) activity, after adjusting for baseline values. In addition, the red ginseng group showed a greater increase in dihydrobiopterin levels and greater decrease in palmitic amide and lysophosphatidylcholines (lysoPCs). The change in diastolic BP positively correlated with changes in lysoPCs and Lp-PLA 2 activity. The BP-lowering effect of red ginseng is associated with decreased Lp-PLA 2 and lysoPCs and increased dihydrobiopterin levels in prehypertensive subjects (ClinicalTrials.gov: NCT02326766).

Original languageEnglish
Pages (from-to)449-456
Number of pages8
JournalHypertension Research
Volume39
Issue number6
DOIs
Publication statusPublished - 2016 Jun 1

Fingerprint

1-Alkyl-2-acetylglycerophosphocholine Esterase
Lysophosphatidylcholines
Panax
Lipoproteins
Blood Pressure
Metabolome
Fasting
Placebos
7,8-dihydrobiopterin
Amides
Liquid Chromatography
Capsules

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

@article{4d24c330f3994b68be7a733df165bb77,
title = "Blood pressure-lowering effect of Korean red ginseng associated with decreased circulating Lp-PLA 2 activity and lysophosphatidylcholines and increased dihydrobiopterin level in prehypertensive subjects",
abstract = "We evaluated the effects of red ginseng consumption on blood pressure (BP) and the fasting plasma metabolome. This randomized, double-blind, placebo-controlled study included nonobese, nondiabetic, prehypertensive subjects consuming 10 capsules daily containing 5 g red ginseng (n=31) or placebo (n=31). Fasting plasma metabolome profiles were obtained using ultra performance liquid chromatography-linear trap quadrupole Orbitrap MS. After 12 weeks, participants consuming red ginseng showed reductions of 6.5 and 5.0 mm Hg in systolic and diastolic BP, respectively. Compared with controls, those consuming red ginseng showed greater reductions in changed values of systolic BP, diastolic BP and lipoprotein-associated phospholipase A 2 (Lp-PLA 2) activity, after adjusting for baseline values. In addition, the red ginseng group showed a greater increase in dihydrobiopterin levels and greater decrease in palmitic amide and lysophosphatidylcholines (lysoPCs). The change in diastolic BP positively correlated with changes in lysoPCs and Lp-PLA 2 activity. The BP-lowering effect of red ginseng is associated with decreased Lp-PLA 2 and lysoPCs and increased dihydrobiopterin levels in prehypertensive subjects (ClinicalTrials.gov: NCT02326766).",
author = "Cha, {Tae Woong} and Minjoo Kim and Minkyung Kim and Chae, {Jey Sook} and Lee, {Jong Ho}",
year = "2016",
month = "6",
day = "1",
doi = "10.1038/hr.2016.7",
language = "English",
volume = "39",
pages = "449--456",
journal = "Hypertension Research",
issn = "0916-9636",
publisher = "Nature Publishing Group",
number = "6",

}

Blood pressure-lowering effect of Korean red ginseng associated with decreased circulating Lp-PLA 2 activity and lysophosphatidylcholines and increased dihydrobiopterin level in prehypertensive subjects. / Cha, Tae Woong; Kim, Minjoo; Kim, Minkyung; Chae, Jey Sook; Lee, Jong Ho.

In: Hypertension Research, Vol. 39, No. 6, 01.06.2016, p. 449-456.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Blood pressure-lowering effect of Korean red ginseng associated with decreased circulating Lp-PLA 2 activity and lysophosphatidylcholines and increased dihydrobiopterin level in prehypertensive subjects

AU - Cha, Tae Woong

AU - Kim, Minjoo

AU - Kim, Minkyung

AU - Chae, Jey Sook

AU - Lee, Jong Ho

PY - 2016/6/1

Y1 - 2016/6/1

N2 - We evaluated the effects of red ginseng consumption on blood pressure (BP) and the fasting plasma metabolome. This randomized, double-blind, placebo-controlled study included nonobese, nondiabetic, prehypertensive subjects consuming 10 capsules daily containing 5 g red ginseng (n=31) or placebo (n=31). Fasting plasma metabolome profiles were obtained using ultra performance liquid chromatography-linear trap quadrupole Orbitrap MS. After 12 weeks, participants consuming red ginseng showed reductions of 6.5 and 5.0 mm Hg in systolic and diastolic BP, respectively. Compared with controls, those consuming red ginseng showed greater reductions in changed values of systolic BP, diastolic BP and lipoprotein-associated phospholipase A 2 (Lp-PLA 2) activity, after adjusting for baseline values. In addition, the red ginseng group showed a greater increase in dihydrobiopterin levels and greater decrease in palmitic amide and lysophosphatidylcholines (lysoPCs). The change in diastolic BP positively correlated with changes in lysoPCs and Lp-PLA 2 activity. The BP-lowering effect of red ginseng is associated with decreased Lp-PLA 2 and lysoPCs and increased dihydrobiopterin levels in prehypertensive subjects (ClinicalTrials.gov: NCT02326766).

AB - We evaluated the effects of red ginseng consumption on blood pressure (BP) and the fasting plasma metabolome. This randomized, double-blind, placebo-controlled study included nonobese, nondiabetic, prehypertensive subjects consuming 10 capsules daily containing 5 g red ginseng (n=31) or placebo (n=31). Fasting plasma metabolome profiles were obtained using ultra performance liquid chromatography-linear trap quadrupole Orbitrap MS. After 12 weeks, participants consuming red ginseng showed reductions of 6.5 and 5.0 mm Hg in systolic and diastolic BP, respectively. Compared with controls, those consuming red ginseng showed greater reductions in changed values of systolic BP, diastolic BP and lipoprotein-associated phospholipase A 2 (Lp-PLA 2) activity, after adjusting for baseline values. In addition, the red ginseng group showed a greater increase in dihydrobiopterin levels and greater decrease in palmitic amide and lysophosphatidylcholines (lysoPCs). The change in diastolic BP positively correlated with changes in lysoPCs and Lp-PLA 2 activity. The BP-lowering effect of red ginseng is associated with decreased Lp-PLA 2 and lysoPCs and increased dihydrobiopterin levels in prehypertensive subjects (ClinicalTrials.gov: NCT02326766).

UR - http://www.scopus.com/inward/record.url?scp=84974720041&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84974720041&partnerID=8YFLogxK

U2 - 10.1038/hr.2016.7

DO - 10.1038/hr.2016.7

M3 - Article

VL - 39

SP - 449

EP - 456

JO - Hypertension Research

JF - Hypertension Research

SN - 0916-9636

IS - 6

ER -