Blood-vessel closure using photosensitizers engineered for two-photon excitation

Hazel A. Collins, Mamta Khurana, Eduardo H. Moriyama, Adrian Mariampillai, Emma Dahlstedt, Milan Balaz, Marina K. Kuimova, Mikhail Drobizhev, Victor X.D. Yang, David Phillips, Aleksander Rebane, Brian C. Wilson, Harry L. Anderson

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280 Citations (Scopus)

Abstract

The spatial control of optical absorption provided by two-photon excitation has led to tremendous advances in microscopy and microfabrication. Medical applications of two-photon excitation in photodynamic therapy have been widely suggested, but thus far have been rendered impractical by the low two-photon cross-sections of photosensitizer drugs (which are compounds taken up by living tissues that become toxic on absorption of light). The invention of efficient two-photon activated drugs will allow precise three-dimensional manipulation of treatment volumes, providing a level of targeting unattainable with current therapeutic techniques. Here we present a new family of photodynamic therapy drugs designed for efficient two-photon excitation and use one of them to demonstrate selective closure of blood vessels through two-photon excitation photodynamic therapy in vivo. These conjugated porphyrin dimers have two-photon cross-sections that are more than two orders of magnitude greater than those of standard clinical photosensitizers. This is the first demonstration of in vivo photodynamic therapy using a photosensitizer engineered for efficient two-photon excitation.

Original languageEnglish
Pages (from-to)420-424
Number of pages5
JournalNature Photonics
Volume2
Issue number7
DOIs
Publication statusPublished - 2008 Jul

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics

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    Collins, H. A., Khurana, M., Moriyama, E. H., Mariampillai, A., Dahlstedt, E., Balaz, M., Kuimova, M. K., Drobizhev, M., Yang, V. X. D., Phillips, D., Rebane, A., Wilson, B. C., & Anderson, H. L. (2008). Blood-vessel closure using photosensitizers engineered for two-photon excitation. Nature Photonics, 2(7), 420-424. https://doi.org/10.1038/nphoton.2008.100