Body mass index is inversely associated with mortality in patients with acute kidney injury undergoing continuous renal replacement therapy

Hyoungnae Kim, Joohwan Kim, Changhwan Seo, Misol Lee, Min Uk Cha, Su Young Jung, Jong Hyun Jhee, Seohyun Park, Hae Ryong Yun, Youn Kyung Kee, Chang Yun Yoon, Hyung Jung Oh, Jung Tak Park, Tae Ik Chang, Tae Hyun Yoo, Shin Wook Kang, Seung Hyeok Han

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Abstract

Background: Many epidemiologic studies have reported on the controversial concept of the obesity paradox. The presence of acute kidney injury (AKI) can accelerate energy-consuming processes, particularly in patients requiring continuous renal replacement therapy (CRRT). Thus, we aimed to investigate whether obesity can provide a survivabenefit in this highly catabolic condition. Methods: We conducted an observational study in 212 patients who had undergone CRRT owing to various causes of AKI between 2010 and 2014. The study end point was defined as death that occurred within 30 days after the initiation of CRRT. Results: Patients were categorized into three groups according to tertiles of body mass index (BMI). During 30 days after the initiation of CRRT, 39 patients (57.4%) in the highest tertile died, as compared with 58 patients (78.4%) in the lowest tertile (P = 0.02). In a multivariable analysis adjusted for cofounding factors, the highest tertile of BMI was significantly associated with a decreased risk of death (hazard ratio [HR], 0.57; 95% confidence interval [CI], 0.37-0.87; P = 0.01). This significant association remained unaltered for 60-day (HR, 0.64; 95% CI, 0.43-0.94; P = 0.03and 90-day mortality (HR, 0.66; 95% CI, 0.44-0.97; P = 0.03). Conclusion: This study showed that a higher BMI confer a survival benefit over a lower BMI in AKI patients undergoing CRRT.

Original languageEnglish
Pages (from-to)39-47
Number of pages9
JournalKidney Research and Clinical Practice
Volume36
Issue number1
DOIs
Publication statusPublished - 2017 Mar

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All Science Journal Classification (ASJC) codes

  • Nephrology
  • Urology

Cite this

Kim, H., Kim, J., Seo, C., Lee, M., Cha, M. U., Jung, S. Y., Jhee, J. H., Park, S., Yun, H. R., Kee, Y. K., Yoon, C. Y., Oh, H. J., Park, J. T., Chang, T. I., Yoo, T. H., Kang, S. W., & Han, S. H. (2017). Body mass index is inversely associated with mortality in patients with acute kidney injury undergoing continuous renal replacement therapy. Kidney Research and Clinical Practice, 36(1), 39-47. https://doi.org/10.23876/j.krcp.2017.36.1.39