Body Mass Index, waist circumference, and health-related quality of life in adults with chronic kidney disease

the KNOW-CKD Study Investigator

Research output: Contribution to journalArticle

Abstract

Purpose: Obesity is linked to poor health-related quality of life (HRQOL) in the general population, but its role in chronic kidney disease (CKD) is uncertain. Methods: We conducted a cross-sectional study that investigated 1880 participants from the KoreaN cohort study for Outcome in patients With CKD (KNOW-CKD) who underwent complete baseline laboratory tests, health questionnaires, and HRQOL. HRQOL was assessed by physical component summary (PCS) and mental component summary (MCS) of the SF-36 questionnaire. We used multivariable linear regression models to examine the relationship between Body Mass Index (BMI) and sex-specific waist circumference (WC) with HRQOL. Results: Adults with higher BMI and greater WC showed lower PCS. After adjusting for age, sex, socioeconomic state, comorbidities, and laboratory findings, we found that WC, but not BMI, was associated with PCS. Greater WC quintiles were associated with lower PCS [WC-4th quintile (β, − 2.63, 95% CI − 5.19 to − 0.06) and WC-5th quintile (β, − 3.71, 95% CI − 6.28 to − 1.15)]. The association between WC and PCS was more pronounced in older adults, woman, patients with diabetes, cardiovascular disease, or lower eGFR. The relationship between BMI and WC with MCS was not significant. Conclusions: In adults with CKD, WC is a better indicator of poor physical HRQOL than BMI. The association between WC and physical HRQOL is modified by age, sex, eGFR, and comorbidities such as diabetes and cardiovascular disease.

Original languageEnglish
Pages (from-to)1075-1083
Number of pages9
JournalQuality of Life Research
Volume28
Issue number4
DOIs
Publication statusPublished - 2019 Apr 15

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Waist Circumference
Chronic Renal Insufficiency
Body Mass Index
Quality of Life
Comorbidity
Linear Models
Cardiovascular Diseases
Cohort Studies
Obesity
Cross-Sectional Studies
Health

All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health

Cite this

@article{f45c6c21f6ea4b1aa4cf4d77035ed176,
title = "Body Mass Index, waist circumference, and health-related quality of life in adults with chronic kidney disease",
abstract = "Purpose: Obesity is linked to poor health-related quality of life (HRQOL) in the general population, but its role in chronic kidney disease (CKD) is uncertain. Methods: We conducted a cross-sectional study that investigated 1880 participants from the KoreaN cohort study for Outcome in patients With CKD (KNOW-CKD) who underwent complete baseline laboratory tests, health questionnaires, and HRQOL. HRQOL was assessed by physical component summary (PCS) and mental component summary (MCS) of the SF-36 questionnaire. We used multivariable linear regression models to examine the relationship between Body Mass Index (BMI) and sex-specific waist circumference (WC) with HRQOL. Results: Adults with higher BMI and greater WC showed lower PCS. After adjusting for age, sex, socioeconomic state, comorbidities, and laboratory findings, we found that WC, but not BMI, was associated with PCS. Greater WC quintiles were associated with lower PCS [WC-4th quintile (β, − 2.63, 95{\%} CI − 5.19 to − 0.06) and WC-5th quintile (β, − 3.71, 95{\%} CI − 6.28 to − 1.15)]. The association between WC and PCS was more pronounced in older adults, woman, patients with diabetes, cardiovascular disease, or lower eGFR. The relationship between BMI and WC with MCS was not significant. Conclusions: In adults with CKD, WC is a better indicator of poor physical HRQOL than BMI. The association between WC and physical HRQOL is modified by age, sex, eGFR, and comorbidities such as diabetes and cardiovascular disease.",
author = "{the KNOW-CKD Study Investigator} and Hyun, {Young Youl} and Lee, {Kyu Beck} and Wookyung Chung and Kim, {Yong Soo} and SeungHyeok Han and Oh, {Yun Kyu} and Chae, {Dong Wan} and Park, {Sue Kyung} and Oh, {Kook Hwan} and Curie Ahn",
year = "2019",
month = "4",
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language = "English",
volume = "28",
pages = "1075--1083",
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Body Mass Index, waist circumference, and health-related quality of life in adults with chronic kidney disease. / the KNOW-CKD Study Investigator.

In: Quality of Life Research, Vol. 28, No. 4, 15.04.2019, p. 1075-1083.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Body Mass Index, waist circumference, and health-related quality of life in adults with chronic kidney disease

AU - the KNOW-CKD Study Investigator

AU - Hyun, Young Youl

AU - Lee, Kyu Beck

AU - Chung, Wookyung

AU - Kim, Yong Soo

AU - Han, SeungHyeok

AU - Oh, Yun Kyu

AU - Chae, Dong Wan

AU - Park, Sue Kyung

AU - Oh, Kook Hwan

AU - Ahn, Curie

PY - 2019/4/15

Y1 - 2019/4/15

N2 - Purpose: Obesity is linked to poor health-related quality of life (HRQOL) in the general population, but its role in chronic kidney disease (CKD) is uncertain. Methods: We conducted a cross-sectional study that investigated 1880 participants from the KoreaN cohort study for Outcome in patients With CKD (KNOW-CKD) who underwent complete baseline laboratory tests, health questionnaires, and HRQOL. HRQOL was assessed by physical component summary (PCS) and mental component summary (MCS) of the SF-36 questionnaire. We used multivariable linear regression models to examine the relationship between Body Mass Index (BMI) and sex-specific waist circumference (WC) with HRQOL. Results: Adults with higher BMI and greater WC showed lower PCS. After adjusting for age, sex, socioeconomic state, comorbidities, and laboratory findings, we found that WC, but not BMI, was associated with PCS. Greater WC quintiles were associated with lower PCS [WC-4th quintile (β, − 2.63, 95% CI − 5.19 to − 0.06) and WC-5th quintile (β, − 3.71, 95% CI − 6.28 to − 1.15)]. The association between WC and PCS was more pronounced in older adults, woman, patients with diabetes, cardiovascular disease, or lower eGFR. The relationship between BMI and WC with MCS was not significant. Conclusions: In adults with CKD, WC is a better indicator of poor physical HRQOL than BMI. The association between WC and physical HRQOL is modified by age, sex, eGFR, and comorbidities such as diabetes and cardiovascular disease.

AB - Purpose: Obesity is linked to poor health-related quality of life (HRQOL) in the general population, but its role in chronic kidney disease (CKD) is uncertain. Methods: We conducted a cross-sectional study that investigated 1880 participants from the KoreaN cohort study for Outcome in patients With CKD (KNOW-CKD) who underwent complete baseline laboratory tests, health questionnaires, and HRQOL. HRQOL was assessed by physical component summary (PCS) and mental component summary (MCS) of the SF-36 questionnaire. We used multivariable linear regression models to examine the relationship between Body Mass Index (BMI) and sex-specific waist circumference (WC) with HRQOL. Results: Adults with higher BMI and greater WC showed lower PCS. After adjusting for age, sex, socioeconomic state, comorbidities, and laboratory findings, we found that WC, but not BMI, was associated with PCS. Greater WC quintiles were associated with lower PCS [WC-4th quintile (β, − 2.63, 95% CI − 5.19 to − 0.06) and WC-5th quintile (β, − 3.71, 95% CI − 6.28 to − 1.15)]. The association between WC and PCS was more pronounced in older adults, woman, patients with diabetes, cardiovascular disease, or lower eGFR. The relationship between BMI and WC with MCS was not significant. Conclusions: In adults with CKD, WC is a better indicator of poor physical HRQOL than BMI. The association between WC and physical HRQOL is modified by age, sex, eGFR, and comorbidities such as diabetes and cardiovascular disease.

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U2 - 10.1007/s11136-018-2084-0

DO - 10.1007/s11136-018-2084-0

M3 - Article

VL - 28

SP - 1075

EP - 1083

JO - Quality of Life Research

JF - Quality of Life Research

SN - 0962-9343

IS - 4

ER -