Body weight fluctuation is associated with rapid kidney function decline

Young Su Joo, Ki Heon Nam, Jong Hyun Jhee, Hae Ryong Yun, Sangmi Lee, Seung Hyeok Han, Tae Hyun Yoo, Shin Wook Kang, Jung Tak Park

Research output: Contribution to journalArticlepeer-review


Objective: This study aimed to evaluate the effects of body weight fluctuations on kidney function deterioration in a prospective cohort of individuals with normal kidney function. Methods: Data were obtained from the Korean Genome and Epidemiology Study. Body weight fluctuations were determined using average successive variability (ASV), which was defined as the average absolute body weight change using repeated measurements for all participants. The decline of the estimated glomerular filtration rate (eGFR) over time was calculated using linear regression analysis of serial eGFR measurements for each patient. Rapid eGFR decline was defined as an average eGFR decline > 3 mL/min/1.73 m2 per year. Results: A total of 6,790 participants were analyzed. During a median follow-up of 11.7 years, rapid eGFR decline was observed in 913 (13.4%) participants. When the participants were categorized into tertiles according to ASV, rapid eGFR decline was more prevalent in the highest ASV tertile group than in the lowest. Analyses using multiple logistic regression models revealed that the risk of rapid eGFR decline was increased in the highest ASV tertile group compared with the lowest (odds ratio: 1.66). Conclusions: Body weight fluctuations were significantly associated with an increased risk of rapid kidney function decline in participants with normal kidney function.

Original languageEnglish
Pages (from-to)257-267
Number of pages11
Issue number1
Publication statusPublished - 2022 Jan

Bibliographical note

Funding Information:
The epidemiologic data used in this study were obtained from the Korean Genome and Epidemiology Study (KoGES; 4851–302) of the National Research Institute of Health, Centers for Disease Control and Prevention, Ministry for Health and Welfare, Republic of Korea.

Publisher Copyright:
© 2021 The Obesity Society.

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Nutrition and Dietetics


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