Bone cement with a modified polyphosphate network structure stimulates hard tissue regeneration

Byung Hyun Lee, Min Ho Hong, Min Chul Kim, Jae Sung Kwon, Yeong Mu Ko, Heon Jin Choi, Yong Keun Lee

Research output: Contribution to journalArticlepeer-review

Abstract

In this study, a calcium polyphosphate cement (CpPC) consisting of basic components was investigated to assess its potential for hard tissue regeneration. The added basic components for improving the structural stability, which controlled the setting time, where the setting reaction resulted in the formation of amorphous structure with a re-constructed polyphosphate. Moreover, the characteristics were controlled by the composition, which determined the polyphosphate structure. CpPC exhibited outstanding dissolution rate compared with the common biodegradable cement, brushite cement (2.5 times). Despite high amounts of dissolution products, no significant cytotoxicity ensued. Induction of calcification in MG-63 cells treated with CpPC, the level of calcification increased with increasing CpPC dissolution rate. Induced calcification was observed also in CpPC-treated ST2 cells, in contrast with MG-63 and ST2 treated with brushite cement, for which no calcification was observed. In vivo tests using a rat calvarial defect model showed that resorbed CpPC resulted in favorable host responses and promoted bone formation. Additionally, there was a significant increase in defect closure, and new bone formation progressed from CpPC mid-sites as well as defect margins. From these results, CpPC exhibits significant potential as biodegradable bone substitute for bone regeneration.

Original languageEnglish
Pages (from-to)344-356
Number of pages13
JournalJournal of Biomaterials Applications
Volume31
Issue number3
DOIs
Publication statusPublished - 2016 Sep 1

Bibliographical note

Funding Information:
This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government MSIP (No. 2008-0062283 and No. 2014M3A7B4051594), the Yonsei-SNU Collaborative Research Fund of 2014, and the Agency for Defense Development (ADD).

Publisher Copyright:
© The Author(s) 2016.

All Science Journal Classification (ASJC) codes

  • Biomaterials
  • Biomedical Engineering

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