Bone marrow mononuclear stem cells transplanted in rat enfarct myocardium improved the electrical conduction without evidence of proarrhythmic effects

Boyoung Joung, Il Kwon Kim, Moon Hyoung Lee, Kyung Jong Yoo, Sung Soon Kim

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Purpose: The arrhythmogenic effect of stem cells transplantation (SCT) in an infarct myocardium is still unknown. We investigated arrhythmogenicity of SCT in rat cryo-infarct model. Materials and Methods: In rat cryo-infarct model, bone marrow mononuclear stem cells (MNSC, 1 × 107 cells) were transplanted into the infarct border zone (BZ) of the LV epicardium. We compared the optical mapping and inducibility of ventricular tachycardia/ fibrillation (VT/VF) among normal (n = 5), cryo-infarct (n = 6), and SCT rats (n = 6). Results: The VT/VF inducibility was higher in the cryo-infarct (47.2%, p = 0.001) and SCT groups (34.6%, p = 0.01) than in the normal group (12.8%). The induced VT/VF episodes persisted for more than 2 minutes in 4.3%, 26.4% and 17.3% in the normal, cryo-infarct and SCT group, respectively. In the SCT group, the action potential duration at 70% was shorter at the SCT site than the BZ during SR (75.2 ± 8.1 vs. 145.6 ± 4.4 ms, p = 0.001) and VT (78.2 ± 13.0 vs. 125.7 ± 21.0 ms, p = 0.001). Conduction block was observed at the SCT site and BZ during VT. However, no reentry or ectopic foci were observed around the SCT sites. Conclusion: The electrical conduction was improved by SCT without evidence of augmentation of arrhythmia in the rat cryo-infarct model.

Original languageEnglish
Pages (from-to)754-764
Number of pages11
JournalYonsei medical journal
Issue number5
Publication statusPublished - 2007 Oct 1


All Science Journal Classification (ASJC) codes

  • Medicine(all)

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