Bone regeneration using a mixture of silicon-substituted coral ha and β-TCP in a rat calvarial bone defect model

Jiyeon Roh, Ji Youn Kim, Young Muk Choi, Seong Min Ha, Kyoung Nam Kim, Kwang Mahn Kim

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The demand of bone graft materials has been increasing. Among various origins of bone graft materials, natural coral composed of up to 99% calcium carbonate was chosen and converted into hydroxyapatite (HA); silicon was then substituted into the HA. Then, the Si-HA was mixed with β-tricalcium phosphate (TCP) in the ratios 100:0 (S100T0), 70:30 (S70T30), 60:40 (S60T40), and 50:50 (S50T50). The materials were implanted for four and eight weeks in a rat calvarial bone defect model (8 mm). The MBCP TM (HA:β-TCP = 60:40, Biomatalante, Vigneux de Bretagne, France) was used as a control. After euthanasia, the bone tissue was analyzed by making histological slides. From the results, S60T40 showed the fastest bone regeneration in four weeks (p < 0.05). In addition, S60T40, S50T50, and MBCPTM showed significant new bone formation in eight weeks (p < 0.05). In conclusion, Si-HA/TCP showed potential as a bone graft material.

Original languageEnglish
Article number97
JournalMaterials
Volume9
Issue number2
DOIs
Publication statusPublished - 2016 Jan 1

Fingerprint

Silicon
Rats
Bone
Phosphates
Durapatite
Hydroxyapatite
Defects
Grafts
Calcium Carbonate
Calcium carbonate
tricalcium phosphate
Tissue

All Science Journal Classification (ASJC) codes

  • Materials Science(all)

Cite this

Roh, Jiyeon ; Kim, Ji Youn ; Choi, Young Muk ; Ha, Seong Min ; Kim, Kyoung Nam ; Kim, Kwang Mahn. / Bone regeneration using a mixture of silicon-substituted coral ha and β-TCP in a rat calvarial bone defect model. In: Materials. 2016 ; Vol. 9, No. 2.
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Bone regeneration using a mixture of silicon-substituted coral ha and β-TCP in a rat calvarial bone defect model. / Roh, Jiyeon; Kim, Ji Youn; Choi, Young Muk; Ha, Seong Min; Kim, Kyoung Nam; Kim, Kwang Mahn.

In: Materials, Vol. 9, No. 2, 97, 01.01.2016.

Research output: Contribution to journalArticle

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