Bone regeneration using three-dimensional hexahedron channel structured BCP block in rabbit calvarial defects

Hyung Chul Pae, Joo Hyun Kang, Jae Kook Cha, Jung Seok Lee, Jeong Won Paik, Ui-Won Jung, Seongho Choi

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The purpose of this study is to evaluate the efficacy of bone regeneration and volume maintenance of the three-dimensional (3D) structured biphasic calcium phosphate (BCP) block with porous hexahedron channels in a rabbit calvarial model. In this work, four circular defects (diameter: 8 mm) in calvarium of rabbits were randomly assigned to (1) negative control (control), (2) 3D hexahedron channel structured BCP block, (3) deproteinized bovine bone mineral particle, and (4) deproteinized porcine bone mineral particle. Animals were euthanized at 2 (n = 5) and 8 weeks (n = 5). Outcome measures included micro-computed tomography (CT) and histomorphometrical analysis. Results indicated that in micro-CT, BCP group showed the highest new bone volume with significant difference compared to control (p = 0.008) at 8 weeks. Histomorphometrically, total augmented area of BCP group was the highest with significant difference compared to control (p = 0.008) at 8 weeks. BCP group also maintained total volume of the original defect without collapsing. BCP block with 3D hexahedron channel structure seems to have favorable osteogenic and volume maintaining ability and highly porous structure might attribute to new bone formation. Further studies regarding the optimal internal structure and porosity of the BCP block bone substitute are needed.

Original languageEnglish
Pages (from-to)2254-2262
Number of pages9
JournalJournal of Biomedical Materials Research - Part B Applied Biomaterials
Volume107
Issue number7
DOIs
Publication statusPublished - 2019 Oct 1

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Calcium phosphate
Bone
Defects
Tomography
Minerals
Bone Substitutes
hydroxyapatite-beta tricalcium phosphate
Animals
Porosity

All Science Journal Classification (ASJC) codes

  • Biomaterials
  • Biomedical Engineering

Cite this

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title = "Bone regeneration using three-dimensional hexahedron channel structured BCP block in rabbit calvarial defects",
abstract = "The purpose of this study is to evaluate the efficacy of bone regeneration and volume maintenance of the three-dimensional (3D) structured biphasic calcium phosphate (BCP) block with porous hexahedron channels in a rabbit calvarial model. In this work, four circular defects (diameter: 8 mm) in calvarium of rabbits were randomly assigned to (1) negative control (control), (2) 3D hexahedron channel structured BCP block, (3) deproteinized bovine bone mineral particle, and (4) deproteinized porcine bone mineral particle. Animals were euthanized at 2 (n = 5) and 8 weeks (n = 5). Outcome measures included micro-computed tomography (CT) and histomorphometrical analysis. Results indicated that in micro-CT, BCP group showed the highest new bone volume with significant difference compared to control (p = 0.008) at 8 weeks. Histomorphometrically, total augmented area of BCP group was the highest with significant difference compared to control (p = 0.008) at 8 weeks. BCP group also maintained total volume of the original defect without collapsing. BCP block with 3D hexahedron channel structure seems to have favorable osteogenic and volume maintaining ability and highly porous structure might attribute to new bone formation. Further studies regarding the optimal internal structure and porosity of the BCP block bone substitute are needed.",
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Bone regeneration using three-dimensional hexahedron channel structured BCP block in rabbit calvarial defects. / Pae, Hyung Chul; Kang, Joo Hyun; Cha, Jae Kook; Lee, Jung Seok; Paik, Jeong Won; Jung, Ui-Won; Choi, Seongho.

In: Journal of Biomedical Materials Research - Part B Applied Biomaterials, Vol. 107, No. 7, 01.10.2019, p. 2254-2262.

Research output: Contribution to journalArticle

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AU - Pae, Hyung Chul

AU - Kang, Joo Hyun

AU - Cha, Jae Kook

AU - Lee, Jung Seok

AU - Paik, Jeong Won

AU - Jung, Ui-Won

AU - Choi, Seongho

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