BRAF mutation in fine-needle aspiration specimens as a potential predictor for persistence/recurrence in patients with classical papillary thyroid carcinoma larger than 10 mm at a BRAF mutation prevalent area

Hee Jung Moon, Eunkyung Kim, Woong Youn Chung, Dong Yeob Shin, jinyoung kwak

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background The association between the BRAF mutation and persistence/recurrence was investigated in patients with classical papillary thyroid carcinoma (PTC) at a BRAF mutation prevalent area. Methods A total of 282 patients with total thyroidectomy and prophylactic central neck dissection were included in this study. The BRAF mutation was evaluated with cytology specimen using dual priming oligonucleotide (DPO)-based multiplex polymerase chain reaction (PCR) and direct sequencing preoperatively. Results Thirty-four patients (12%) had persistence/recurrence. In all PTC, the BRAF mutation on both methods was not associated with persistence/recurrence. In PTC >10 mm, the BRAF mutation on DPO-based multiplex PCR was significantly associated with persistence/recurrence and a potential predictor for persistence/recurrence. In PTC ≤10 mm, none of the covariates were significantly different between patients with and without persistence/recurrence. Conclusion The BRAF mutation was significantly associated with persistence/recurrence and a potential predictor in patients with classical PTC >10 mm at a BRAF mutation prevalent area.

Original languageEnglish
Pages (from-to)1432-1438
Number of pages7
JournalHead and Neck
Volume37
Issue number10
DOIs
Publication statusPublished - 2015 Oct 1

Fingerprint

Fine Needle Biopsy
Recurrence
Mutation
Multiplex Polymerase Chain Reaction
Oligonucleotides
Neck Dissection
Thyroidectomy
Papillary Thyroid cancer
Cell Biology

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology

Cite this

@article{9bcf8a9e4df14fefa35c3028572199d5,
title = "BRAF mutation in fine-needle aspiration specimens as a potential predictor for persistence/recurrence in patients with classical papillary thyroid carcinoma larger than 10 mm at a BRAF mutation prevalent area",
abstract = "Background The association between the BRAF mutation and persistence/recurrence was investigated in patients with classical papillary thyroid carcinoma (PTC) at a BRAF mutation prevalent area. Methods A total of 282 patients with total thyroidectomy and prophylactic central neck dissection were included in this study. The BRAF mutation was evaluated with cytology specimen using dual priming oligonucleotide (DPO)-based multiplex polymerase chain reaction (PCR) and direct sequencing preoperatively. Results Thirty-four patients (12{\%}) had persistence/recurrence. In all PTC, the BRAF mutation on both methods was not associated with persistence/recurrence. In PTC >10 mm, the BRAF mutation on DPO-based multiplex PCR was significantly associated with persistence/recurrence and a potential predictor for persistence/recurrence. In PTC ≤10 mm, none of the covariates were significantly different between patients with and without persistence/recurrence. Conclusion The BRAF mutation was significantly associated with persistence/recurrence and a potential predictor in patients with classical PTC >10 mm at a BRAF mutation prevalent area.",
author = "Moon, {Hee Jung} and Eunkyung Kim and Chung, {Woong Youn} and Shin, {Dong Yeob} and jinyoung kwak",
year = "2015",
month = "10",
day = "1",
doi = "10.1002/hed.23770",
language = "English",
volume = "37",
pages = "1432--1438",
journal = "Head and Neck",
issn = "1043-3074",
publisher = "John Wiley and Sons Inc.",
number = "10",

}

TY - JOUR

T1 - BRAF mutation in fine-needle aspiration specimens as a potential predictor for persistence/recurrence in patients with classical papillary thyroid carcinoma larger than 10 mm at a BRAF mutation prevalent area

AU - Moon, Hee Jung

AU - Kim, Eunkyung

AU - Chung, Woong Youn

AU - Shin, Dong Yeob

AU - kwak, jinyoung

PY - 2015/10/1

Y1 - 2015/10/1

N2 - Background The association between the BRAF mutation and persistence/recurrence was investigated in patients with classical papillary thyroid carcinoma (PTC) at a BRAF mutation prevalent area. Methods A total of 282 patients with total thyroidectomy and prophylactic central neck dissection were included in this study. The BRAF mutation was evaluated with cytology specimen using dual priming oligonucleotide (DPO)-based multiplex polymerase chain reaction (PCR) and direct sequencing preoperatively. Results Thirty-four patients (12%) had persistence/recurrence. In all PTC, the BRAF mutation on both methods was not associated with persistence/recurrence. In PTC >10 mm, the BRAF mutation on DPO-based multiplex PCR was significantly associated with persistence/recurrence and a potential predictor for persistence/recurrence. In PTC ≤10 mm, none of the covariates were significantly different between patients with and without persistence/recurrence. Conclusion The BRAF mutation was significantly associated with persistence/recurrence and a potential predictor in patients with classical PTC >10 mm at a BRAF mutation prevalent area.

AB - Background The association between the BRAF mutation and persistence/recurrence was investigated in patients with classical papillary thyroid carcinoma (PTC) at a BRAF mutation prevalent area. Methods A total of 282 patients with total thyroidectomy and prophylactic central neck dissection were included in this study. The BRAF mutation was evaluated with cytology specimen using dual priming oligonucleotide (DPO)-based multiplex polymerase chain reaction (PCR) and direct sequencing preoperatively. Results Thirty-four patients (12%) had persistence/recurrence. In all PTC, the BRAF mutation on both methods was not associated with persistence/recurrence. In PTC >10 mm, the BRAF mutation on DPO-based multiplex PCR was significantly associated with persistence/recurrence and a potential predictor for persistence/recurrence. In PTC ≤10 mm, none of the covariates were significantly different between patients with and without persistence/recurrence. Conclusion The BRAF mutation was significantly associated with persistence/recurrence and a potential predictor in patients with classical PTC >10 mm at a BRAF mutation prevalent area.

UR - http://www.scopus.com/inward/record.url?scp=84941749021&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84941749021&partnerID=8YFLogxK

U2 - 10.1002/hed.23770

DO - 10.1002/hed.23770

M3 - Article

C2 - 24838814

AN - SCOPUS:84941749021

VL - 37

SP - 1432

EP - 1438

JO - Head and Neck

JF - Head and Neck

SN - 1043-3074

IS - 10

ER -