BRAF wild papillary thyroid carcinoma has two distinct mRNA expression patterns with different clinical behaviors

Hyeung Kyoo Kim, Inhwa Lee, Jeonghun Lee, Hang Seok Chang, Euy Young Soh, Il Seok Park, Jin Hwan Kim, Young Soo Rho, Dong Jin Lee

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: Using a large set of genomic data from The Cancer Genome Atlas (TCGA), we classified BRAF wild papillary thyroid carcinomas (PTCs) into 2 subtypes with distinct molecular patterns and different clinical behaviors. We also suggested gene signatures (RAS-score) to predict molecular subtypes and clinical behaviors of BRAF wild PTC. Method: Integrated genomic analysis was done using all genomic data of PTC in TCGA data portal (https://tcga-data.nci.nih.gov) and cancer browser (https://genome-cancer.ucsc.edu). Using Gene Ontology and a logistic regression test, we selected gene signatures (RAS-score) and applied this prediction model to the validation cohort (GSE60542). Result: When we performed multiplatform genomic analysis, BRAF wild PTCs were divided into 2 molecular subtypes. Each subtype showed distinct molecular patterns and clinical behaviors. Gene signatures successfully predicted molecular subtype in another validation cohort. Conclusion: We found that BRAF wild PTCs were divided into 2 molecular subtypes and each subtype showed distinct molecular patterns, different activated pathways, and different clinical behaviors.

Original languageEnglish
Pages (from-to)1707-1718
Number of pages12
JournalHead and Neck
Volume40
Issue number8
DOIs
Publication statusPublished - 2018 Aug

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology

Fingerprint Dive into the research topics of 'BRAF <sup>wild</sup> papillary thyroid carcinoma has two distinct mRNA expression patterns with different clinical behaviors'. Together they form a unique fingerprint.

  • Cite this

    Kim, H. K., Lee, I., Lee, J., Chang, H. S., Soh, E. Y., Park, I. S., Kim, J. H., Rho, Y. S., & Lee, D. J. (2018). BRAF wild papillary thyroid carcinoma has two distinct mRNA expression patterns with different clinical behaviors Head and Neck, 40(8), 1707-1718. https://doi.org/10.1002/hed.25151