Brain Metastasis from Non-Small Cell Lung Cancer: Use of Epidermal Growth Factor Receptor and HER2 Status for Targeted Therapy

Hyo Sup Shim, JaSeung Koo, SeHoon Kim

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Brain metastases are a major cause of morbidity and mortality in patients with non-small cell lung carcinomas. However, effective therapies have not yet been developed. Targeted therapies based on driver genetic alterations are becoming standard treatment for patients with non-small cell lung carcinomas. Thus, effective therapy for brain metastases should be established based on the elucidation of critical genetic events related to metastases. Epidermal growth factor receptor or HER2 deregulation has been observed in brain metastatic tissue but had not been observed in primary lung carcinoma. Because there are readily available therapeutic agents for these abnormalities, targeted therapies that are more specific to brain metastases would be beneficial.

Original languageEnglish
Title of host publicationBrain Metastases from Primary Tumors
Subtitle of host publicationEpidemiology, Biology, and Therapy
PublisherElsevier Inc.
Pages69-75
Number of pages7
Volume2
ISBN (Electronic)9780128016893
ISBN (Print)9780128014196
DOIs
Publication statusPublished - 2015 Jan 8

All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Neuroscience(all)

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    Shim, H. S., Koo, J., & Kim, S. (2015). Brain Metastasis from Non-Small Cell Lung Cancer: Use of Epidermal Growth Factor Receptor and HER2 Status for Targeted Therapy. In Brain Metastases from Primary Tumors: Epidemiology, Biology, and Therapy (Vol. 2, pp. 69-75). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-801419-6.00005-7