Brain regional iron contents in progressive supranuclear palsy

Seung Ha Lee, Chul Hyoung Lyoo, Sung Jun Ahn, Juha O. Rinne, Myung Sik Lee

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Introduction To determine motor-related brain regions in which iron contents correlate with the degree of motor deficits of progressive supranuclear palsy (PSP). Methods Twenty-four patients with probable PSP and 20 controls were included. Using a 3.0T magnetic resonance imaging scanner, R2* values were measured in the putamen, globus pallidus (GP), substantia nigra (SN), subthalamic nucleus, and dentate nucleus. After adjustment for disease duration and age at examination, correlations between regional brain R2* values and Unified Parkinson Disease Rating Scale (UPDRS) total motor scores or subscores for bradykinesia, rigidity, tremor, or axial motor deficits were investigated. Results Compared to controls, patients with PSP had significantly higher R2* values in all of the five brain regions. UPDRS total motor scores and subscores for bradykinesia and axial motor deficits did not correlate with R2* values of the five brain regions. However, UPDRS subscores for unilateral rigidity were correlated with R2* values of the contralateral putamen and GP. In addition, unilateral UPDRS subscores for tremor were associated with R2* values of the ipsilateral dentate nucleus, contralateral putamen, GP, and SN. Conclusion In PSP, excessive iron accumulation occurs in motor-related subcortical regions. Iron-related PSP pathologies in the lenticular nucleus are associated with rigidity severity, while those in the nigro-striato-pallidal unit and dentate nucleus are associated with tremor severity. Bradykinesia and axial motor deficits of PSP seem to be associated with widespread pathologies in the cerebrum, brainstem, cerebellum, as well as the basal ganglia.

Original languageEnglish
Pages (from-to)28-32
Number of pages5
JournalParkinsonism and Related Disorders
Volume45
DOIs
Publication statusPublished - 2017 Dec

Fingerprint

Progressive Supranuclear Palsy
Iron
Cerebellar Nuclei
Hypokinesia
Globus Pallidus
Parkinson Disease
Putamen
Brain
Tremor
Substantia Nigra
Pathology
Corpus Striatum
Subthalamic Nucleus
Cerebrum
Basal Ganglia
Cerebellum
Brain Stem
Magnetic Resonance Imaging

All Science Journal Classification (ASJC) codes

  • Neurology
  • Geriatrics and Gerontology
  • Clinical Neurology

Cite this

Lee, Seung Ha ; Lyoo, Chul Hyoung ; Ahn, Sung Jun ; Rinne, Juha O. ; Lee, Myung Sik. / Brain regional iron contents in progressive supranuclear palsy. In: Parkinsonism and Related Disorders. 2017 ; Vol. 45. pp. 28-32.
@article{fb7b56d6275d4199ba1ba64fade0f66f,
title = "Brain regional iron contents in progressive supranuclear palsy",
abstract = "Introduction To determine motor-related brain regions in which iron contents correlate with the degree of motor deficits of progressive supranuclear palsy (PSP). Methods Twenty-four patients with probable PSP and 20 controls were included. Using a 3.0T magnetic resonance imaging scanner, R2* values were measured in the putamen, globus pallidus (GP), substantia nigra (SN), subthalamic nucleus, and dentate nucleus. After adjustment for disease duration and age at examination, correlations between regional brain R2* values and Unified Parkinson Disease Rating Scale (UPDRS) total motor scores or subscores for bradykinesia, rigidity, tremor, or axial motor deficits were investigated. Results Compared to controls, patients with PSP had significantly higher R2* values in all of the five brain regions. UPDRS total motor scores and subscores for bradykinesia and axial motor deficits did not correlate with R2* values of the five brain regions. However, UPDRS subscores for unilateral rigidity were correlated with R2* values of the contralateral putamen and GP. In addition, unilateral UPDRS subscores for tremor were associated with R2* values of the ipsilateral dentate nucleus, contralateral putamen, GP, and SN. Conclusion In PSP, excessive iron accumulation occurs in motor-related subcortical regions. Iron-related PSP pathologies in the lenticular nucleus are associated with rigidity severity, while those in the nigro-striato-pallidal unit and dentate nucleus are associated with tremor severity. Bradykinesia and axial motor deficits of PSP seem to be associated with widespread pathologies in the cerebrum, brainstem, cerebellum, as well as the basal ganglia.",
author = "Lee, {Seung Ha} and Lyoo, {Chul Hyoung} and Ahn, {Sung Jun} and Rinne, {Juha O.} and Lee, {Myung Sik}",
year = "2017",
month = "12",
doi = "10.1016/j.parkreldis.2017.09.020",
language = "English",
volume = "45",
pages = "28--32",
journal = "Parkinsonism and Related Disorders",
issn = "1353-8020",
publisher = "Elsevier BV",

}

Brain regional iron contents in progressive supranuclear palsy. / Lee, Seung Ha; Lyoo, Chul Hyoung; Ahn, Sung Jun; Rinne, Juha O.; Lee, Myung Sik.

In: Parkinsonism and Related Disorders, Vol. 45, 12.2017, p. 28-32.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Brain regional iron contents in progressive supranuclear palsy

AU - Lee, Seung Ha

AU - Lyoo, Chul Hyoung

AU - Ahn, Sung Jun

AU - Rinne, Juha O.

AU - Lee, Myung Sik

PY - 2017/12

Y1 - 2017/12

N2 - Introduction To determine motor-related brain regions in which iron contents correlate with the degree of motor deficits of progressive supranuclear palsy (PSP). Methods Twenty-four patients with probable PSP and 20 controls were included. Using a 3.0T magnetic resonance imaging scanner, R2* values were measured in the putamen, globus pallidus (GP), substantia nigra (SN), subthalamic nucleus, and dentate nucleus. After adjustment for disease duration and age at examination, correlations between regional brain R2* values and Unified Parkinson Disease Rating Scale (UPDRS) total motor scores or subscores for bradykinesia, rigidity, tremor, or axial motor deficits were investigated. Results Compared to controls, patients with PSP had significantly higher R2* values in all of the five brain regions. UPDRS total motor scores and subscores for bradykinesia and axial motor deficits did not correlate with R2* values of the five brain regions. However, UPDRS subscores for unilateral rigidity were correlated with R2* values of the contralateral putamen and GP. In addition, unilateral UPDRS subscores for tremor were associated with R2* values of the ipsilateral dentate nucleus, contralateral putamen, GP, and SN. Conclusion In PSP, excessive iron accumulation occurs in motor-related subcortical regions. Iron-related PSP pathologies in the lenticular nucleus are associated with rigidity severity, while those in the nigro-striato-pallidal unit and dentate nucleus are associated with tremor severity. Bradykinesia and axial motor deficits of PSP seem to be associated with widespread pathologies in the cerebrum, brainstem, cerebellum, as well as the basal ganglia.

AB - Introduction To determine motor-related brain regions in which iron contents correlate with the degree of motor deficits of progressive supranuclear palsy (PSP). Methods Twenty-four patients with probable PSP and 20 controls were included. Using a 3.0T magnetic resonance imaging scanner, R2* values were measured in the putamen, globus pallidus (GP), substantia nigra (SN), subthalamic nucleus, and dentate nucleus. After adjustment for disease duration and age at examination, correlations between regional brain R2* values and Unified Parkinson Disease Rating Scale (UPDRS) total motor scores or subscores for bradykinesia, rigidity, tremor, or axial motor deficits were investigated. Results Compared to controls, patients with PSP had significantly higher R2* values in all of the five brain regions. UPDRS total motor scores and subscores for bradykinesia and axial motor deficits did not correlate with R2* values of the five brain regions. However, UPDRS subscores for unilateral rigidity were correlated with R2* values of the contralateral putamen and GP. In addition, unilateral UPDRS subscores for tremor were associated with R2* values of the ipsilateral dentate nucleus, contralateral putamen, GP, and SN. Conclusion In PSP, excessive iron accumulation occurs in motor-related subcortical regions. Iron-related PSP pathologies in the lenticular nucleus are associated with rigidity severity, while those in the nigro-striato-pallidal unit and dentate nucleus are associated with tremor severity. Bradykinesia and axial motor deficits of PSP seem to be associated with widespread pathologies in the cerebrum, brainstem, cerebellum, as well as the basal ganglia.

UR - http://www.scopus.com/inward/record.url?scp=85030231549&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85030231549&partnerID=8YFLogxK

U2 - 10.1016/j.parkreldis.2017.09.020

DO - 10.1016/j.parkreldis.2017.09.020

M3 - Article

C2 - 28982612

AN - SCOPUS:85030231549

VL - 45

SP - 28

EP - 32

JO - Parkinsonism and Related Disorders

JF - Parkinsonism and Related Disorders

SN - 1353-8020

ER -