Breast cancer detected at screening US

Survival rates and clinical-pathologic and imaging factors associated with recurrence

Soo Yeon Kim, Boo Kyung Han, Eunkyung Kim, Woo Jung Choi, Yunhee Choi, Hak Hee Kim, Woo Kyung Moon

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Purpose: To determine the survival rates and clinical-pathologic and imaging factors associated with recurrence in women with breast cancer detected at screening ultrasonography (US). Materials and Methods: This study was approved by the institutional review board, and the requirement to obtain informed consent was waived. A retrospective review of the databases of four institutions identified 501 women (median age, 47 years; range, 27-74 years) with breast cancer (425 invasive cancers and 76 ductal carcinoma in situ) detected at screening US between January 2004 and March 2011. Five-year overall survival (OS) and recurrence-free survival (RFS) rates were estimated, and the clinical-pathologic and imaging data were collected. Multivariate analysis was performed by using Cox proportional hazard regression to determine factors associated with recurrence. Results: At a median follow-up of 7.0 years (range, 5.0-12.1 years), 15 (3.0%) recurrences were detected: five in ipsilateral breast and 10 in contralateral breast. The 5-year OS and RFS rates were 100% and 98.0% (95% confidence interval [CI]: 96.8%, 99.2%), respectively. In patients with invasive cancers, age younger than 40 years (hazard ratio: 3.632 [95% CI: 1.099, 11.998]; P = .032), the triple-negative subtype (hazard ratio: 7.498 [95% CI: 2.266, 24.816]; P = .001), and Breast Imaging Reporting and Data System (BI-RADS) category 4A lesions (hazard ratio: 5.113 [95% CI: 1.532, 17.195]; P = .008) were associated with recurrence. Conclusion: Women with breast cancers detected at screening US have excellent outcomes, with a 5-year RFS rate of 98.0%. However, in patients with invasive breast cancer, age younger than 40 years, the triple-negative subtype, and BI-RADS category 4A lesions were associated with recurrence.

Original languageEnglish
Pages (from-to)354-364
Number of pages11
JournalRadiology
Volume284
Issue number2
DOIs
Publication statusPublished - 2017 Aug 1

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Ultrasonography
Survival Rate
Breast Neoplasms
Recurrence
Breast
Confidence Intervals
Information Systems
Carcinoma, Intraductal, Noninfiltrating
Survival
Research Ethics Committees
Informed Consent
Neoplasms
Multivariate Analysis
Databases

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

Cite this

Kim, Soo Yeon ; Han, Boo Kyung ; Kim, Eunkyung ; Choi, Woo Jung ; Choi, Yunhee ; Kim, Hak Hee ; Moon, Woo Kyung. / Breast cancer detected at screening US : Survival rates and clinical-pathologic and imaging factors associated with recurrence. In: Radiology. 2017 ; Vol. 284, No. 2. pp. 354-364.
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abstract = "Purpose: To determine the survival rates and clinical-pathologic and imaging factors associated with recurrence in women with breast cancer detected at screening ultrasonography (US). Materials and Methods: This study was approved by the institutional review board, and the requirement to obtain informed consent was waived. A retrospective review of the databases of four institutions identified 501 women (median age, 47 years; range, 27-74 years) with breast cancer (425 invasive cancers and 76 ductal carcinoma in situ) detected at screening US between January 2004 and March 2011. Five-year overall survival (OS) and recurrence-free survival (RFS) rates were estimated, and the clinical-pathologic and imaging data were collected. Multivariate analysis was performed by using Cox proportional hazard regression to determine factors associated with recurrence. Results: At a median follow-up of 7.0 years (range, 5.0-12.1 years), 15 (3.0{\%}) recurrences were detected: five in ipsilateral breast and 10 in contralateral breast. The 5-year OS and RFS rates were 100{\%} and 98.0{\%} (95{\%} confidence interval [CI]: 96.8{\%}, 99.2{\%}), respectively. In patients with invasive cancers, age younger than 40 years (hazard ratio: 3.632 [95{\%} CI: 1.099, 11.998]; P = .032), the triple-negative subtype (hazard ratio: 7.498 [95{\%} CI: 2.266, 24.816]; P = .001), and Breast Imaging Reporting and Data System (BI-RADS) category 4A lesions (hazard ratio: 5.113 [95{\%} CI: 1.532, 17.195]; P = .008) were associated with recurrence. Conclusion: Women with breast cancers detected at screening US have excellent outcomes, with a 5-year RFS rate of 98.0{\%}. However, in patients with invasive breast cancer, age younger than 40 years, the triple-negative subtype, and BI-RADS category 4A lesions were associated with recurrence.",
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Breast cancer detected at screening US : Survival rates and clinical-pathologic and imaging factors associated with recurrence. / Kim, Soo Yeon; Han, Boo Kyung; Kim, Eunkyung; Choi, Woo Jung; Choi, Yunhee; Kim, Hak Hee; Moon, Woo Kyung.

In: Radiology, Vol. 284, No. 2, 01.08.2017, p. 354-364.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Breast cancer detected at screening US

T2 - Survival rates and clinical-pathologic and imaging factors associated with recurrence

AU - Kim, Soo Yeon

AU - Han, Boo Kyung

AU - Kim, Eunkyung

AU - Choi, Woo Jung

AU - Choi, Yunhee

AU - Kim, Hak Hee

AU - Moon, Woo Kyung

PY - 2017/8/1

Y1 - 2017/8/1

N2 - Purpose: To determine the survival rates and clinical-pathologic and imaging factors associated with recurrence in women with breast cancer detected at screening ultrasonography (US). Materials and Methods: This study was approved by the institutional review board, and the requirement to obtain informed consent was waived. A retrospective review of the databases of four institutions identified 501 women (median age, 47 years; range, 27-74 years) with breast cancer (425 invasive cancers and 76 ductal carcinoma in situ) detected at screening US between January 2004 and March 2011. Five-year overall survival (OS) and recurrence-free survival (RFS) rates were estimated, and the clinical-pathologic and imaging data were collected. Multivariate analysis was performed by using Cox proportional hazard regression to determine factors associated with recurrence. Results: At a median follow-up of 7.0 years (range, 5.0-12.1 years), 15 (3.0%) recurrences were detected: five in ipsilateral breast and 10 in contralateral breast. The 5-year OS and RFS rates were 100% and 98.0% (95% confidence interval [CI]: 96.8%, 99.2%), respectively. In patients with invasive cancers, age younger than 40 years (hazard ratio: 3.632 [95% CI: 1.099, 11.998]; P = .032), the triple-negative subtype (hazard ratio: 7.498 [95% CI: 2.266, 24.816]; P = .001), and Breast Imaging Reporting and Data System (BI-RADS) category 4A lesions (hazard ratio: 5.113 [95% CI: 1.532, 17.195]; P = .008) were associated with recurrence. Conclusion: Women with breast cancers detected at screening US have excellent outcomes, with a 5-year RFS rate of 98.0%. However, in patients with invasive breast cancer, age younger than 40 years, the triple-negative subtype, and BI-RADS category 4A lesions were associated with recurrence.

AB - Purpose: To determine the survival rates and clinical-pathologic and imaging factors associated with recurrence in women with breast cancer detected at screening ultrasonography (US). Materials and Methods: This study was approved by the institutional review board, and the requirement to obtain informed consent was waived. A retrospective review of the databases of four institutions identified 501 women (median age, 47 years; range, 27-74 years) with breast cancer (425 invasive cancers and 76 ductal carcinoma in situ) detected at screening US between January 2004 and March 2011. Five-year overall survival (OS) and recurrence-free survival (RFS) rates were estimated, and the clinical-pathologic and imaging data were collected. Multivariate analysis was performed by using Cox proportional hazard regression to determine factors associated with recurrence. Results: At a median follow-up of 7.0 years (range, 5.0-12.1 years), 15 (3.0%) recurrences were detected: five in ipsilateral breast and 10 in contralateral breast. The 5-year OS and RFS rates were 100% and 98.0% (95% confidence interval [CI]: 96.8%, 99.2%), respectively. In patients with invasive cancers, age younger than 40 years (hazard ratio: 3.632 [95% CI: 1.099, 11.998]; P = .032), the triple-negative subtype (hazard ratio: 7.498 [95% CI: 2.266, 24.816]; P = .001), and Breast Imaging Reporting and Data System (BI-RADS) category 4A lesions (hazard ratio: 5.113 [95% CI: 1.532, 17.195]; P = .008) were associated with recurrence. Conclusion: Women with breast cancers detected at screening US have excellent outcomes, with a 5-year RFS rate of 98.0%. However, in patients with invasive breast cancer, age younger than 40 years, the triple-negative subtype, and BI-RADS category 4A lesions were associated with recurrence.

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