Breast conserving therapy in stage I and II breast cancer in Korea

Hy De Lee, Dong Sup Yoon, Ja Yun Koo, Chang Ok Suh, Woo Hee Jung, Ki Keun Oh

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

A randomized clinical study of 187 patients with T1, T2 breast cancer was performed, in order to compare the effects of modified radical mastectomy (MRM) and breast conserving therapy (BCT) on breast recurrence, overall survival, and disease-free survival. One hundred eighty seven patients with T1, T2 breast cancer, admitted at Yongdong Severance Hospital from April 1991 to August 1994, were randomized into two different treatment groups. Of the 187 patients, 111 patients had received MRM and 76 had received BCT. In any of the variables considered with the exceptions of age and menopausal status, patient characteristics such as tumor size, incidence of axillary lymph node metastasis, histologic grading, and estrogen and progesterone receptor positive rate were not significantly different between the two groups (p > 0.05). Using the Kaplan-Meier Product-limit method and log-rank test, the difference of locoregional recurrence, and overall and disease-free survival, between these comparable groups was analyzed. Average follow-up period was 37.6 months. Two out of 111 MRM patients and two out of 76 BCT patients had locoregional recurrence. Only one patient who had MRM was found to have a recurrence in her opposite breast. The overall survival rates in MRM and BCT patients were, respectively, 93.7% and 94.1%. Furthermore, the disease-free survival rates were, respectively, 89.2% and 93.9%. This result indicates that there were no significant differences between two groups in locoregional recurrence, and overall and disease-free survival. Having gained a better cosmetic appearance, the conservative treatment group was satisfied with the BCT. In this study, we conclude that BCT is a good alternative surgical treatment modality for T1, T2 Korean breast cancer patients, which could substitute for the more traditional MRM. However, further follow-up will be needed for long-term results.

Original languageEnglish
Pages (from-to)193-199
Number of pages7
JournalBreast Cancer Research and Treatment
Volume44
Issue number3
DOIs
Publication statusPublished - 1997 Jul 28

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Korea
Modified Radical Mastectomy
Breast
Breast Neoplasms
Disease-Free Survival
Recurrence
Therapeutics
Survival Rate
Kaplan-Meier Estimate
Progesterone Receptors
Cosmetics
Estrogen Receptors
Lymph Nodes
Neoplasm Metastasis
Survival
Incidence

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Lee, Hy De ; Yoon, Dong Sup ; Koo, Ja Yun ; Suh, Chang Ok ; Jung, Woo Hee ; Oh, Ki Keun. / Breast conserving therapy in stage I and II breast cancer in Korea. In: Breast Cancer Research and Treatment. 1997 ; Vol. 44, No. 3. pp. 193-199.
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abstract = "A randomized clinical study of 187 patients with T1, T2 breast cancer was performed, in order to compare the effects of modified radical mastectomy (MRM) and breast conserving therapy (BCT) on breast recurrence, overall survival, and disease-free survival. One hundred eighty seven patients with T1, T2 breast cancer, admitted at Yongdong Severance Hospital from April 1991 to August 1994, were randomized into two different treatment groups. Of the 187 patients, 111 patients had received MRM and 76 had received BCT. In any of the variables considered with the exceptions of age and menopausal status, patient characteristics such as tumor size, incidence of axillary lymph node metastasis, histologic grading, and estrogen and progesterone receptor positive rate were not significantly different between the two groups (p > 0.05). Using the Kaplan-Meier Product-limit method and log-rank test, the difference of locoregional recurrence, and overall and disease-free survival, between these comparable groups was analyzed. Average follow-up period was 37.6 months. Two out of 111 MRM patients and two out of 76 BCT patients had locoregional recurrence. Only one patient who had MRM was found to have a recurrence in her opposite breast. The overall survival rates in MRM and BCT patients were, respectively, 93.7{\%} and 94.1{\%}. Furthermore, the disease-free survival rates were, respectively, 89.2{\%} and 93.9{\%}. This result indicates that there were no significant differences between two groups in locoregional recurrence, and overall and disease-free survival. Having gained a better cosmetic appearance, the conservative treatment group was satisfied with the BCT. In this study, we conclude that BCT is a good alternative surgical treatment modality for T1, T2 Korean breast cancer patients, which could substitute for the more traditional MRM. However, further follow-up will be needed for long-term results.",
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Breast conserving therapy in stage I and II breast cancer in Korea. / Lee, Hy De; Yoon, Dong Sup; Koo, Ja Yun; Suh, Chang Ok; Jung, Woo Hee; Oh, Ki Keun.

In: Breast Cancer Research and Treatment, Vol. 44, No. 3, 28.07.1997, p. 193-199.

Research output: Contribution to journalArticle

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