Brief Report

Malignancies in Adults Living With HIV in Asia

Awachana Jiamsakul, Mark Polizzotto, Stephane Wen-Wei Ku, Junko Tanuma, Eugenie Hui, Romanee Chaiwarith, Sasisopin Kiertiburanakul, Anchalee Avihingasanon, Evy Yunihastuti, Nagalingeswaran Kumarasamy, Penh Sun Ly, Sanjay Pujari, Rossana Ditangco, Cuong Duy Do, Tuti Parwati Merati, Pacharee Kantipong, Fujie Zhang, Kinh Van Nguyen, Adeeba Kamarulzaman, JunYong Choi & 4 others Benedict L.H. Sim, Oon Tek Ng, Jeremy Ross, Wingwai Wong

Research output: Contribution to journalArticle

Abstract

BACKGROUND: Hematological malignancies have continued to be highly prevalent among people living with HIV (PLHIV). This study assessed the occurrence of, risk factors for, and outcomes of hematological and nonhematological malignancies in PLHIV in Asia. METHODS: Incidence of malignancy after cohort enrollment was evaluated. Factors associated with development of hematological and nonhematological malignancy were analyzed using competing risk regression and survival time using Kaplan-Meier. RESULTS: Of 7455 patients, 107 patients (1%) developed a malignancy: 34 (0.5%) hematological [0.08 per 100 person-years (/100PY)] and 73 (1%) nonhematological (0.17/100PY). Of the hematological malignancies, non-Hodgkin lymphoma was predominant (n = 26, 76%): immunoblastic (n = 6, 18%), Burkitt (n = 5, 15%), diffuse large B-cell (n = 5, 15%), and unspecified (n = 10, 30%). Others include central nervous system lymphoma (n = 7, 21%) and myelodysplastic syndrome (n = 1, 3%). Nonhematological malignancies were mostly Kaposi sarcoma (n = 12, 16%) and cervical cancer (n = 10, 14%). Risk factors for hematological malignancy included age >50 vs. ≤30 years [subhazard ratio (SHR) = 6.48, 95% confidence interval (CI): 1.79 to 23.43] and being from a high-income vs. a lower-middle-income country (SHR = 3.97, 95% CI: 1.45 to 10.84). Risk was reduced with CD4 351-500 cells/µL (SHR = 0.20, 95% CI: 0.05 to 0.74) and CD4 >500 cells/µL (SHR = 0.14, 95% CI: 0.04 to 0.78), compared to CD4 ≤200 cells/µL. Similar risk factors were seen for nonhematological malignancy, with prior AIDS diagnosis showing a weak association. Patients diagnosed with a hematological malignancy had shorter survival time compared to patients diagnosed with a nonhematological malignancy. CONCLUSIONS: Nonhematological malignancies were common but non-Hodgkin lymphoma was more predominant in our cohort. PLHIV from high-income countries were more likely to be diagnosed, indicating a potential underdiagnosis of cancer in low-income settings.

Original languageEnglish
Pages (from-to)301-307
Number of pages7
JournalJournal of acquired immune deficiency syndromes (1999)
Volume80
Issue number3
DOIs
Publication statusPublished - 2019 Mar 1

Fingerprint

Hematologic Neoplasms
HIV
Neoplasms
Confidence Intervals
Non-Hodgkin's Lymphoma
Survival
Kaposi's Sarcoma
Myelodysplastic Syndromes
Uterine Cervical Neoplasms
Lymphoma
Acquired Immunodeficiency Syndrome
B-Lymphocytes
Central Nervous System
Incidence

All Science Journal Classification (ASJC) codes

  • Infectious Diseases
  • Pharmacology (medical)

Cite this

Jiamsakul, A., Polizzotto, M., Wen-Wei Ku, S., Tanuma, J., Hui, E., Chaiwarith, R., ... Wong, W. (2019). Brief Report: Malignancies in Adults Living With HIV in Asia. Journal of acquired immune deficiency syndromes (1999), 80(3), 301-307. https://doi.org/10.1097/QAI.0000000000001918
Jiamsakul, Awachana ; Polizzotto, Mark ; Wen-Wei Ku, Stephane ; Tanuma, Junko ; Hui, Eugenie ; Chaiwarith, Romanee ; Kiertiburanakul, Sasisopin ; Avihingasanon, Anchalee ; Yunihastuti, Evy ; Kumarasamy, Nagalingeswaran ; Ly, Penh Sun ; Pujari, Sanjay ; Ditangco, Rossana ; Do, Cuong Duy ; Merati, Tuti Parwati ; Kantipong, Pacharee ; Zhang, Fujie ; Van Nguyen, Kinh ; Kamarulzaman, Adeeba ; Choi, JunYong ; Sim, Benedict L.H. ; Ng, Oon Tek ; Ross, Jeremy ; Wong, Wingwai. / Brief Report : Malignancies in Adults Living With HIV in Asia. In: Journal of acquired immune deficiency syndromes (1999). 2019 ; Vol. 80, No. 3. pp. 301-307.
@article{3034a9ec67a24d21863ec9df9b1f3696,
title = "Brief Report: Malignancies in Adults Living With HIV in Asia",
abstract = "BACKGROUND: Hematological malignancies have continued to be highly prevalent among people living with HIV (PLHIV). This study assessed the occurrence of, risk factors for, and outcomes of hematological and nonhematological malignancies in PLHIV in Asia. METHODS: Incidence of malignancy after cohort enrollment was evaluated. Factors associated with development of hematological and nonhematological malignancy were analyzed using competing risk regression and survival time using Kaplan-Meier. RESULTS: Of 7455 patients, 107 patients (1{\%}) developed a malignancy: 34 (0.5{\%}) hematological [0.08 per 100 person-years (/100PY)] and 73 (1{\%}) nonhematological (0.17/100PY). Of the hematological malignancies, non-Hodgkin lymphoma was predominant (n = 26, 76{\%}): immunoblastic (n = 6, 18{\%}), Burkitt (n = 5, 15{\%}), diffuse large B-cell (n = 5, 15{\%}), and unspecified (n = 10, 30{\%}). Others include central nervous system lymphoma (n = 7, 21{\%}) and myelodysplastic syndrome (n = 1, 3{\%}). Nonhematological malignancies were mostly Kaposi sarcoma (n = 12, 16{\%}) and cervical cancer (n = 10, 14{\%}). Risk factors for hematological malignancy included age >50 vs. ≤30 years [subhazard ratio (SHR) = 6.48, 95{\%} confidence interval (CI): 1.79 to 23.43] and being from a high-income vs. a lower-middle-income country (SHR = 3.97, 95{\%} CI: 1.45 to 10.84). Risk was reduced with CD4 351-500 cells/µL (SHR = 0.20, 95{\%} CI: 0.05 to 0.74) and CD4 >500 cells/µL (SHR = 0.14, 95{\%} CI: 0.04 to 0.78), compared to CD4 ≤200 cells/µL. Similar risk factors were seen for nonhematological malignancy, with prior AIDS diagnosis showing a weak association. Patients diagnosed with a hematological malignancy had shorter survival time compared to patients diagnosed with a nonhematological malignancy. CONCLUSIONS: Nonhematological malignancies were common but non-Hodgkin lymphoma was more predominant in our cohort. PLHIV from high-income countries were more likely to be diagnosed, indicating a potential underdiagnosis of cancer in low-income settings.",
author = "Awachana Jiamsakul and Mark Polizzotto and {Wen-Wei Ku}, Stephane and Junko Tanuma and Eugenie Hui and Romanee Chaiwarith and Sasisopin Kiertiburanakul and Anchalee Avihingasanon and Evy Yunihastuti and Nagalingeswaran Kumarasamy and Ly, {Penh Sun} and Sanjay Pujari and Rossana Ditangco and Do, {Cuong Duy} and Merati, {Tuti Parwati} and Pacharee Kantipong and Fujie Zhang and {Van Nguyen}, Kinh and Adeeba Kamarulzaman and JunYong Choi and Sim, {Benedict L.H.} and Ng, {Oon Tek} and Jeremy Ross and Wingwai Wong",
year = "2019",
month = "3",
day = "1",
doi = "10.1097/QAI.0000000000001918",
language = "English",
volume = "80",
pages = "301--307",
journal = "Journal of Acquired Immune Deficiency Syndromes",
issn = "1525-4135",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

Jiamsakul, A, Polizzotto, M, Wen-Wei Ku, S, Tanuma, J, Hui, E, Chaiwarith, R, Kiertiburanakul, S, Avihingasanon, A, Yunihastuti, E, Kumarasamy, N, Ly, PS, Pujari, S, Ditangco, R, Do, CD, Merati, TP, Kantipong, P, Zhang, F, Van Nguyen, K, Kamarulzaman, A, Choi, J, Sim, BLH, Ng, OT, Ross, J & Wong, W 2019, 'Brief Report: Malignancies in Adults Living With HIV in Asia', Journal of acquired immune deficiency syndromes (1999), vol. 80, no. 3, pp. 301-307. https://doi.org/10.1097/QAI.0000000000001918

Brief Report : Malignancies in Adults Living With HIV in Asia. / Jiamsakul, Awachana; Polizzotto, Mark; Wen-Wei Ku, Stephane; Tanuma, Junko; Hui, Eugenie; Chaiwarith, Romanee; Kiertiburanakul, Sasisopin; Avihingasanon, Anchalee; Yunihastuti, Evy; Kumarasamy, Nagalingeswaran; Ly, Penh Sun; Pujari, Sanjay; Ditangco, Rossana; Do, Cuong Duy; Merati, Tuti Parwati; Kantipong, Pacharee; Zhang, Fujie; Van Nguyen, Kinh; Kamarulzaman, Adeeba; Choi, JunYong; Sim, Benedict L.H.; Ng, Oon Tek; Ross, Jeremy; Wong, Wingwai.

In: Journal of acquired immune deficiency syndromes (1999), Vol. 80, No. 3, 01.03.2019, p. 301-307.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Brief Report

T2 - Malignancies in Adults Living With HIV in Asia

AU - Jiamsakul, Awachana

AU - Polizzotto, Mark

AU - Wen-Wei Ku, Stephane

AU - Tanuma, Junko

AU - Hui, Eugenie

AU - Chaiwarith, Romanee

AU - Kiertiburanakul, Sasisopin

AU - Avihingasanon, Anchalee

AU - Yunihastuti, Evy

AU - Kumarasamy, Nagalingeswaran

AU - Ly, Penh Sun

AU - Pujari, Sanjay

AU - Ditangco, Rossana

AU - Do, Cuong Duy

AU - Merati, Tuti Parwati

AU - Kantipong, Pacharee

AU - Zhang, Fujie

AU - Van Nguyen, Kinh

AU - Kamarulzaman, Adeeba

AU - Choi, JunYong

AU - Sim, Benedict L.H.

AU - Ng, Oon Tek

AU - Ross, Jeremy

AU - Wong, Wingwai

PY - 2019/3/1

Y1 - 2019/3/1

N2 - BACKGROUND: Hematological malignancies have continued to be highly prevalent among people living with HIV (PLHIV). This study assessed the occurrence of, risk factors for, and outcomes of hematological and nonhematological malignancies in PLHIV in Asia. METHODS: Incidence of malignancy after cohort enrollment was evaluated. Factors associated with development of hematological and nonhematological malignancy were analyzed using competing risk regression and survival time using Kaplan-Meier. RESULTS: Of 7455 patients, 107 patients (1%) developed a malignancy: 34 (0.5%) hematological [0.08 per 100 person-years (/100PY)] and 73 (1%) nonhematological (0.17/100PY). Of the hematological malignancies, non-Hodgkin lymphoma was predominant (n = 26, 76%): immunoblastic (n = 6, 18%), Burkitt (n = 5, 15%), diffuse large B-cell (n = 5, 15%), and unspecified (n = 10, 30%). Others include central nervous system lymphoma (n = 7, 21%) and myelodysplastic syndrome (n = 1, 3%). Nonhematological malignancies were mostly Kaposi sarcoma (n = 12, 16%) and cervical cancer (n = 10, 14%). Risk factors for hematological malignancy included age >50 vs. ≤30 years [subhazard ratio (SHR) = 6.48, 95% confidence interval (CI): 1.79 to 23.43] and being from a high-income vs. a lower-middle-income country (SHR = 3.97, 95% CI: 1.45 to 10.84). Risk was reduced with CD4 351-500 cells/µL (SHR = 0.20, 95% CI: 0.05 to 0.74) and CD4 >500 cells/µL (SHR = 0.14, 95% CI: 0.04 to 0.78), compared to CD4 ≤200 cells/µL. Similar risk factors were seen for nonhematological malignancy, with prior AIDS diagnosis showing a weak association. Patients diagnosed with a hematological malignancy had shorter survival time compared to patients diagnosed with a nonhematological malignancy. CONCLUSIONS: Nonhematological malignancies were common but non-Hodgkin lymphoma was more predominant in our cohort. PLHIV from high-income countries were more likely to be diagnosed, indicating a potential underdiagnosis of cancer in low-income settings.

AB - BACKGROUND: Hematological malignancies have continued to be highly prevalent among people living with HIV (PLHIV). This study assessed the occurrence of, risk factors for, and outcomes of hematological and nonhematological malignancies in PLHIV in Asia. METHODS: Incidence of malignancy after cohort enrollment was evaluated. Factors associated with development of hematological and nonhematological malignancy were analyzed using competing risk regression and survival time using Kaplan-Meier. RESULTS: Of 7455 patients, 107 patients (1%) developed a malignancy: 34 (0.5%) hematological [0.08 per 100 person-years (/100PY)] and 73 (1%) nonhematological (0.17/100PY). Of the hematological malignancies, non-Hodgkin lymphoma was predominant (n = 26, 76%): immunoblastic (n = 6, 18%), Burkitt (n = 5, 15%), diffuse large B-cell (n = 5, 15%), and unspecified (n = 10, 30%). Others include central nervous system lymphoma (n = 7, 21%) and myelodysplastic syndrome (n = 1, 3%). Nonhematological malignancies were mostly Kaposi sarcoma (n = 12, 16%) and cervical cancer (n = 10, 14%). Risk factors for hematological malignancy included age >50 vs. ≤30 years [subhazard ratio (SHR) = 6.48, 95% confidence interval (CI): 1.79 to 23.43] and being from a high-income vs. a lower-middle-income country (SHR = 3.97, 95% CI: 1.45 to 10.84). Risk was reduced with CD4 351-500 cells/µL (SHR = 0.20, 95% CI: 0.05 to 0.74) and CD4 >500 cells/µL (SHR = 0.14, 95% CI: 0.04 to 0.78), compared to CD4 ≤200 cells/µL. Similar risk factors were seen for nonhematological malignancy, with prior AIDS diagnosis showing a weak association. Patients diagnosed with a hematological malignancy had shorter survival time compared to patients diagnosed with a nonhematological malignancy. CONCLUSIONS: Nonhematological malignancies were common but non-Hodgkin lymphoma was more predominant in our cohort. PLHIV from high-income countries were more likely to be diagnosed, indicating a potential underdiagnosis of cancer in low-income settings.

UR - http://www.scopus.com/inward/record.url?scp=85061481888&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85061481888&partnerID=8YFLogxK

U2 - 10.1097/QAI.0000000000001918

DO - 10.1097/QAI.0000000000001918

M3 - Article

VL - 80

SP - 301

EP - 307

JO - Journal of Acquired Immune Deficiency Syndromes

JF - Journal of Acquired Immune Deficiency Syndromes

SN - 1525-4135

IS - 3

ER -

Jiamsakul A, Polizzotto M, Wen-Wei Ku S, Tanuma J, Hui E, Chaiwarith R et al. Brief Report: Malignancies in Adults Living With HIV in Asia. Journal of acquired immune deficiency syndromes (1999). 2019 Mar 1;80(3):301-307. https://doi.org/10.1097/QAI.0000000000001918