Brimonidine 0.2% versus brimonidine purite 0.15% in Asian ocular hypertension

Chan Yun Kim, Samin Hong, Gong Je Seong

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Purpose: The aim of this study was to evaluate the efficacy and safety of brimonidine 0.2% versus brimonidine Purite 0.15% in Asians with ocular hypertension. Methods: This study was a prospective, randomized, observer-masked, short-term crossover trial. Eighty-six (86) Asian subjects with newly diagnosed ocular hypertension were randomly assigned to receive either brimonidine 0.2% or brimonidine Purite 0.15%, both dosed twice a day for 4 weeks. Subjects were then washed out for 6 weeks and switched to the opposite treatment for 4 weeks. Results: The baseline intraocular pressure (IOP) was 24.4 ± 2.45 mmHg for brimonidine 0.2% and 24.39 ± 2.56 mmHg for brimonidine Purite 0.15% (P = 0.985). The IOP was at trough drug effect after 4 weeks of brimonidine 0.2% and brimonidine Purite 0.15% therapy were 20.10 ± 2.01 mmHg and 21.00 ± 1.67 mmHg (P = 0.001), respectively. The IOP at peak drug effect after 4 weeks of brimonidine 0.2% and brimonidine Purite 0.15% treatment were 18.10 ± 1.73 mmHg and 18.20 ± 1.71 mmHg (P = 0.518), respectively. Brimonidine 0.2% was found to cause more allergic conjunctivitis than brimonidine Purite 0.15% (P < 0.001). Conclusions: Brimonidine 0.2% has a higher potency of lowering IOP than brimonidine Purite 0.15% at trough when used twice-daily. However, ocular allergic reaction was more frequent and severe with brimonidine 0.2% than with brimonidine Purite 0.15%.

Original languageEnglish
Pages (from-to)481-486
Number of pages6
JournalJournal of Ocular Pharmacology and Therapeutics
Issue number5
Publication statusPublished - 2007 Oct 1


All Science Journal Classification (ASJC) codes

  • Ophthalmology
  • Pharmacology
  • Pharmacology (medical)

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