Broad network-based predictability of Saccharomyces cerevisiae gene loss-of-function phenotypes

Kriston L. McGary, In suk Lee, Edward M. Marcotte

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

We demonstrate that loss-of-function yeast phenotypes are predictable by guilt-by-association in functional gene networks. Testing 1,102 loss-of-function phenotypes from genome-wide assays of yeast reveals predictability of diverse phenotypes, spanning cellular morphology, growth, metabolism, and quantitative cell shape features. We apply the method to extend a genome-wide screen by predicting, then verifying, genes whose disruption elongates yeast cells, and to predict human disease genes. To facilitate network-guided screens, a web server is available http://www.yeastnet.org.

Original languageEnglish
Article numberR258
JournalGenome biology
Volume8
Issue number12
DOIs
Publication statusPublished - 2007 Dec 5

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yeast
Saccharomyces cerevisiae
phenotype
Yeasts
yeasts
Phenotype
gene
genome
Genome
Genes
Guilt
genes
Cell Shape
Gene Regulatory Networks
gene targeting
human diseases
metabolism
assay
cells
assays

All Science Journal Classification (ASJC) codes

  • Ecology, Evolution, Behavior and Systematics
  • Genetics
  • Cell Biology

Cite this

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Broad network-based predictability of Saccharomyces cerevisiae gene loss-of-function phenotypes. / McGary, Kriston L.; Lee, In suk; Marcotte, Edward M.

In: Genome biology, Vol. 8, No. 12, R258, 05.12.2007.

Research output: Contribution to journalArticle

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