Broad network-based predictability of Saccharomyces cerevisiae gene loss-of-function phenotypes

Kriston L. McGary, Insuk Lee, Edward M. Marcotte

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

We demonstrate that loss-of-function yeast phenotypes are predictable by guilt-by-association in functional gene networks. Testing 1,102 loss-of-function phenotypes from genome-wide assays of yeast reveals predictability of diverse phenotypes, spanning cellular morphology, growth, metabolism, and quantitative cell shape features. We apply the method to extend a genome-wide screen by predicting, then verifying, genes whose disruption elongates yeast cells, and to predict human disease genes. To facilitate network-guided screens, a web server is available http://www.yeastnet.org.

Original languageEnglish
Article numberR258
JournalGenome biology
Volume8
Issue number12
DOIs
Publication statusPublished - 2007 Dec 5

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All Science Journal Classification (ASJC) codes

  • Ecology, Evolution, Behavior and Systematics
  • Genetics
  • Cell Biology

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